Melatonin as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs...
When I first read the studies linked and excerpted below I thought the authors were talking about me. Of all of the multiple myeloma side effects I’ve sustained, radiation damage (fibrosis) is by far the most extensive. And I supplement with low doses of melatonin.
I underwent radiation at three different times during my conventional cancer treatments.
I experienced a series of short, long-term and late stage side effects from my radiation therapies.
I have been searching for therapies to either heal or slow my multiple myeloma side effects- radiation fibrosis in particular.
I should have done many things before, during and immediately after my radiation therapy. But that was a longtime ago. The important thing now is to undergo those therapies that studies show can help me.
I take melatonin several times a week. I take small doses so that I can supplement often. I get a better night’s sleep and I am helping my radiation-induced fibrosis.
I am both a multiple myeloma survivor and MM cancer coach. Have you been diagnosed with multiple myeloma? Are you considering radiation therapy? Have you already undergone therapy?
I take Life Extension Melatonin Time Released Vegetarian Tablets, 300 mcg. though there are many different dose levels, I take a tiny dose before bed. Further, I take Life Extension products because LEF products have been evaluated and approved repeatedly by Consumerlab.com.
I recommend trying this low dose level of melatonin. See how you like it. Let me know.
To Learn More about Chemotherapy and Radiation-induced Nerve Damage- click now
Thanks
David Emerson
- Multiple Myeloma Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Recommended Reading:
“Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune system responses play a pivotal role in many of the early and late side effects of radiation. Moreover, immune cells have a significant role in tumor response to radiotherapy, such as angiogenesis and tumor growth. Mel as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs...
Moreover, anti-cancer properties of mel may increase the therapeutic ratio of radiotherapy…
It seems anti-proliferative, anti-angiogenesis, and stimulation or suppression of some immune cell responses are the main anti-tumor effects of mel that may help to improve response of the tumor to radiotherapy…”
“Radiotherapy is one of the most relevant treatment options for cancer therapy with or without other treatment modalities including immunotherapy, surgery and chemotherapy. Exposure to heavy doses of ionizing radiation during radiotherapy results in short and long term side effects. It appears that many of these side effects are linked to inflammatory responses during treatment or after prolonged use. Inflammation is mediated by various genes and cytokines related to immune system responses caused by massive cell death following radiotherapy…
“Background: We investigated whether topical administration of melatonin ameliorates radiation-induced skin fibrosis (RISF) and inhibits the expression of profibrogenic genes in mice.
Fourteen days after IR, the relative levels of transforming growth factor (TGF)-β1 mRNA expression and TGF-β1 protein in skin specimens were analyzed by real-time quantitative PCR and immunohistochemical staining.
Results: The Radiation caused a 2.2-fold increase in TGF-β1 mRNA expression relative to that in control group, which was decreased by 37% following melatonin treatment (P = 0.024). We also observed substantial reduction of TGF-β1 expression in immunohistochemical studies. The mean values of dermal thickness were 105 ± 11 μm (Control), 195 ± 21 μm (IR), and 148 ± 19 μm (Mel+IR).
Dermal thickness and collagen accumulation, which increased in the IR group, was significantly reduced by topically applied melatonin.
Conclusion: Topical administration of melatonin successfully attenuated RISF.
“PURPOSE: Although radiation is one of the basic methods commonly used in cancer treatment, it inevitably enters the field of treatment in healthy tissues and is adversely affected by the acute and chronic side effects of radiation. This study evaluated the possible protective effects of quercetin, an antioxidant agent, against liver and kidney damage in rats exposed to a whole-body single dose of radiation (10 Gy of gamma-ray)…
CONCLUSIONS: With the results obtained from the study; Quercetin is thought to have a protective potential against radiation-induced liver and kidney damage due to its radioprotective effect…”
“The use of some agents as radioprotectors has been evaluated for protection against normal tissue toxicity following exposure to ionizing radiation. Resveratrol, a natural flavonoid, with antioxidant and anti-inflammatory properties has attracted research interests for its radioprotective potential.
This study systematically evaluates existing studies to examine the radioprotective effectiveness of resveratrol. A literature search of the electronic databases, including PubMed, Scopus, and Embase was conducted to retrieve articles investigating the protective effect of resveratrol against ionizing radiation-induced damage to normal tissues.
The search timeframe ranged from the inception of each database to January 2020. From an initial search of 231 articles, and after the removal of duplicates as well as applying the predetermined inclusion and exclusion criteria, 33 articles were finally included for this systematic review. Results showed promising protective effect of resveratrol against ionizing radiation-induced damage to normal tissues. Furthermore, no adverse effect was observed after administering resveratrol.
Resveratrol showed the potential to protect against ionizing radiation-induced damage to normal tissue cells via notable mechanisms, including anti-apoptotic and anti-inflammatory effects.
However, further studies on the efficacy of clinical translation of resveratrol would open up more insights, while other gray areas such as the optimal radioprotective dosage of resveratrol requires further investigation.
Overall, resveratrol is a potential double-edged sword in cancer therapy while protecting healthy tissues…”
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