Mesothelioma- Multimodal approach may triple overall survival-

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“it is widely accepted that best long term results after treatment for malignant pleural mesothelioma are achieved when several modalities are combined.”

Mesothelioma (meso) is an aggressive cancer with a poor overall survival outlook. Therefore I look at mesothelioma as I do my own incurable cancer, multiple myeloma. Experience has taught me that you must take a multimodal approach to treating mesothelioma.

I have always balanced conventional therapies (FDA approved) with evidence-based, non-conventional (multimodal) therapies.

The studies linked and excerped below cite mesothelioma therapies that your oncolosgist might not have discussed with you.

I first tried conventional chemo, radiation and an autologus stem cell transplant. Remission, relapse, remission, then terminal. And then I went on to try a host of non-conventional therapies.

Light-Based Therapy Extends Mesothelioma Survival

“The newest research on photodynamic therapy appears to confirm what multiple recent studies have found – that PDT is a safe and effective way to prolong survival in pleural mesothelioma patients after surgery…

“After two decades of clinical studies, intrapleural photodynamic therapy after surgical resection became a safe treatment that significantly improved the survival of patients,”

Meso patients undergoing PDT get an injection of a photosensitizing drug several days before treatment. The most popular drug for this purpose is porfimer sodium (Photofrin), which has been recognized with orphan drug status by the FDA for its potential in treating meso. Meso cells absorb more of the photosensitizer and retain it longer than healthy cells, which is one of the reasons PDT produces fewer side effects than chemotherapy or radiation

A 2012 study of 97 pleural meso patients found that PDT after pleurectomy tripled survival times from around a year to more than 3 years. Other recent studies have produced encouraging results by combining PDT with chemotherapy, suggesting that the two treatments may work synergistically to fight meso.”

Mesothelioma Nutritional Therapy

“The chronic production of the above mentioned mediators of inflammation, caused by asbestos exposure, may be critical for malignant transformation and the formation of Malignant Mesothelioma”

I don’t follow conventional oncology in the traditional sense. If I understand the study linked and excerpted below, asbestos fibers that are inhaled into a person’s lungs get stuck and cause inflammation. This inflammation, after years and years, causes “ cell growth and collagen deposition.” Overproduction of collagen, cell growth and genetic changes can lead to mesothelioma.

You can read the study linked and excerpted below but I’m pretty sure that my explanation above is the gist of it.

All that complicated jargon followed by a nutritional therapy that the study shows may reduce or stop this inflammation. Flaxseed lignans prevent acute inflammation… in mice anyway. This complementary therapy wouldn’t amount to much, in my opinion, were it not for the fact that other non-conventional therapies has also been shown to reduce the inflammation caused by mesothelioma.

Over the past fifteen or so years I have researched and written about more than a dozen therapies that improve the prognosis for Meso patients. Some of these are conventional therapies like surgery and radiation and some of these therapies are evidenced-based  non-conventional like nutrition generally and flaxseed specifically.

My point is that like my cancer, multiple myeloma, the standard approach taken by conventional oncology can be limited.

Recommended Reading:

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice

“Discussion-Acute exposure to asbestos in the peritoneal cavity induced inflammation which was characterized by WBC accumulation and proinflammatory and profibrogenic cytokine release, as well as being associated with gene expression changes in genes of relevance to inflammation and fibrosis…

The inflammatory and fibrogenic responses induced by asbestos exposure are associated with the location of asbestos fiber deposition and are linked with growth factor release…, agents that ultimately lead to cell growth and collagen deposition (5,28–31). The chronic production of the above mentioned mediators of inflammation, caused by asbestos exposure, may be critical for malignant transformation and the formation of MM (23,29,32,33) through the induction of DNA damage, defective cell cycle control mechanisms, prolonged angiogenesis, uncontrollable growth signaling and tissue invasion/metastasis (10,34,35). Thus, blocking the release of these mediators might be helpful in preventing the development of mesothelioma…”

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