Metastatic Melanoma and Angiogenesis

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Melanoma Can’t Metastasize (Spread) Without Growing New Blood Vessels (Angiogenesis)- Consider Evidence-Based, Non-Toxic Anti-Angiogenesis

If you have been diagnosed with melanoma your prognosis depends largely on the ability for your cancer to metastasize aka spread. Once tumor cells spread, then then grow. In order for tumors to grow, they need to sprout blood vessels. This concept, angiogenesis, is central to all cancers. Even blood cancers. Metastatic Melanoma (MM) is considered to be incurable by conventional oncology.

Click the image below to enlarge-

Skin Cancer Mind Map

My cancer, myeloma, is also considered to be incurable. I mention this because I have managed my myeloma since my diagnosis in early 1994. While I understand why conventional oncology relies on the FDA for the study and approval of cancer therapies, I also understand that survivors of incurable cancers must look beyond conventional oncology if they are to manage their cancer for the long term.

As you can see from the illustration to the left, skin cancer is complicated. Once melanoma spreads or becomes metastatic the prognosis of the patient worsens.

Though there are few conventional (FDA approved) therapies for the treatment of metastatic melanoma, there are a number of evidence-based, non-toxic therapies that are both anti-angiogenic and which will reduce the risk of skin cancer spreading.

Have you been diagnosed with skin cancer? What therapies have you already undergone or are considering undergoing?

I am both a long-term cancer survivor and cancer coach. Scroll down the page, post a question or comment and I will reply to you ASAP.


David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Current concepts of metastasis in melanoma

“Abstract-The main cause of death in melanoma patients is widespread metastases. Staging of melanoma is based on the primary tumor thickness, ulceration, lymph node and distant metastases…

It is generally believed that a neoplastic process progresses through several stages: tumor initiation, progression, invasion and then metastasis…

Vessel formation

Formation of new vessels in primary and metastatic tumors is of extreme importance. This is thought to occur through the recapitulation of embryonic vessel formation (i.e., vasculogenic mimicry). This is defined more strictly as endothelial-like features being acquired by tumor cells. The tumor microenvironment, that is, interstitial fluid pressure, pH, cytokines, laminin, collagens, growth factors, nutrients and oxygen, is thought to stimulate angiogenesis through different mechanisms…

With regard to melanoma metastases in other sites, the number of microvessels in melanoma metastases in the brain was lower than the number seen in metastases to the breast or lung, and their diameter was intermediate when compared with these two types of metastases [85]. This finding was unexpected, since brain melanoma metastases are characterized by extremely frequent hemorrhage.


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