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MGUS (pre-myeloma) and Kidney Damage

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Because they do not meet conditions for smoldering multiple myeloma or MM, these patients are mistakenly diagnosed as MGUS (or pre-myeloma) 

I’m going to have to throw myself on the mercy of the court this time. For the life of me I can’t figure out what the studies linked and excerpted below are saying. Other than MGUS or monoclonal gammopathy can cause kidney damage. What I can say is that kidney damage is a common symptom of monoclonal gammopathies and conventional oncology offers little in the way of kidney detox therapy.

While kidney cleanse or kidney detoxes are less than evidence-based therapies, they are all you can do if you want to improve your kidney function. Scroll all the way down the page to learn more about kidney cleansing.

If you have been diagnosed with MGUS, SMM or MM and your creatinine or other kidney function tests are abnormal, please ask your oncologist to have an immunofluoresence study.

MGUS at a glance-


If you do not want to “watch and wait” to see if your MGUS progresses to Multiple Myeloma please watch the short video below:


Consider MGUS Therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve MGUS/SMM and MM
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. Non-conventional bone health therapies

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant

“Indeed, a growing number of pathologic renal conditions are being attributed to a clonal plasma cell disorder that is less “myeloma-like” and more “MGUS-like” in terms of its bulk and proliferative rate.11,12 Unfortunately, the current diagnostic schema fails to properly categorize the hematologic disorder in these patients. Because they do not meet conditions for smoldering multiple myeloma or MM, these patients are mistakenly diagnosed as MGUS...

Unfortunately, MGUS in this context is misrepresented because in these patients there is significance to the monoclonal gammopathy, and its significance is not “undetermined.” Despite their nonmalignant nature, these diseases are associated with a great deal of morbidity and even mortality.10,12,16

MGUS should not be used to describe hematologic disorders that result in kidney disease. It is because of this necessity that we propose the term “monoclonal gammopathy of renal significance” (MGRS) to discriminate the pathologic nature of these diseases from the truly benign MGUS…

Although the MGUS-like biology sometimes makes the hematologic disease less lethal, the effect on the kidney regrettably is not as benign

Kidney disease associated with plasma cell dyscrasias

“Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury…”

Kidney Damage- Natural Detox Therapies

Non-conventional therapies aka kidney cleanses are less than evidence-based. Meaning, few, if any studies have been conducted into natural kidney cleansing.

I’ve said this in many of my blog posts on PeopleBeatingCancer. When we MM patients and survivors are faced with a health problem that is related to our MM, we may not be able to find a suitable or effective therapy provided by conventional oncology.

Remember that conventional oncology considers MM to be incurable. There are a host of multiple myeloma symptoms that conventional oncology just can’t fix. There are several MM symptoms and side effects that conventional oncology creates with chemotherapy and radiation.

Think chemobrain, heart damage, blood clots, cataracts and the list goes on…

If I was a newly diagnosed MM patient experiencing kidney damage and wanted to improve my kidney function/health, I would:

  • talk to my conventional MD
  • meet with a naturopath with an expertise in kidney health
  • and finally, consider the natural kidney cleansing therapies linked below-

The articles linked below are those articles, recipes, videos, etc. that I find to be credible and, though not “evidence-based,” may offer therapies for kidney patients to consider.

Recommended Reading:

Before You Try a Kidney Cleanse

“Kidneys also release three important hormones: erythropoietin (which stimulates the bone marrow to make red blood cells), renin (which regulates blood pressure), and calcitriol (the active form of vitamin D, which helps maintain calcium for bones and for normal chemical balance in the body)…

If you’re interested in taking natural approaches to enhance your kidney health, talk with your doctor and consider consulting a qualified health professional.

Kidney cleanses vary in approach. Here’s a look at some of the most common types of kidney cleanses:
  • Beet juice
  • Watermelon
  • Lemon juice
  • Cranberry juice
  • Pumpkin seeds
  • Smoothies
  • Ginger
  • Turmeric
Vitamins-Some proponents recommend incorporating the following vitamins and minerals into a kidney cleanse:
  • Vitamin B2
  • Vitamin B6
  • Magnesium
In many cases, a kidney cleanse will integrate herbs, vitamins, and minerals into a whole-foods-based diet designed to flush out the kidneys.

Possible Concerns- While kidney-cleanse proponents suggest that they enhance the kidneys’ ability to remove waste from the body, their claim/s are not backed by scientific data. Like other supplements, the Food and Drug Administration (FDA) doesn’t require products marketed for kidney cleansing be proven safe and effective. While consumers face such risks when purchasing any dietary supplement, these risks may be of greater magnitude with supplements containing a variety of herbs in high doses.

Doing a Natural Kidney Cleanse at Home

“The kidneys are two small organs located on either side of the spine, below the ribs. They play an important role in getting rid of excess waste, balancing electrolytes, and creating hormones.

In the absence of disease, a well-rounded diet and adequate water intake are usually enough to keep your kidneys healthy.

However, certain foods, herbs, and supplements can help support strong kidneys.

From your morning glass of water to that extra cup of herbal tea, here are four ways to cleanse your kidneys and keep them functioning strong

  1. Hydration is key
  2. Choose foods that support kidney health
  3. Drink kidney-cleansing teas
  4. Supplement with supportive nutrients

YouTube Video Demonstrating Kidney Cleansing Drink

I found this video to be a bit silly but the cocktail/recipe seemed legit.

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