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MGUS- Evidence-Based, Non-Toxic Therapies

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Don’t Want to “Watch and Wait?” Reduce Your Risks of Multiple Myeloma, Lose a Few Pounds, Get Healthy and Feel Great-

A diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is tricky as this asymptomatic blood disorder can progress to multiple myeloma, an incurable blood cancer. Adding to your challenge is that conventional oncology will tell the MGUS patients to “watch and wait.” And that there is no FDA approved therapy that can slow or reverse MGUS’s march toward MM.

MGUS at a glance-

While it is correct that there is no FDA approved treatment to treat monoclonal gammopathy of undetermined significance  there are evidence-based, non-conventional therapies that can down regulate MGUS proteins. “Down-regulating” MGUS proteins is oncology-speak for normalizing your blood.

To learn more about the evidence-based protocols you can follow to prevent your Pre-Myeloma from becoming Multiple Myeloma, please watch the short video below:

The study and short video linked and excerpted below carefully explain that curcumin, and I’m translating medical jargon here, suppresses MM cells thus providing a therapy for MGUS sufferers.

While this is good news for monoclonal gammopathy of undetermined significance  patients, even more good news is that there are several other evidence-based non-toxic, non-conventional therapies that, like curcumin, also down-regulate NK factorB MM cells.

I am both a long-term MM survivor and MM cancer coach. I have lived in complete remission from my multiple myeloma since 1999 by living an evidence-based, non-toxic, anti-MM lifestyle.

If you do not want to “watch and wait” to see if your monoclonal gammopathy of undetermined significance progresses to Multiple Myeloma scroll down the page, post a question or a comment and I will reply to you ASAP.

Consider MGUS Therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve multiple myeloma
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. Non-conventional bone health therapies
  6. Cannabis/CBD?THC oil

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.

“…Overall, our results indicate that curcumin down-regulates NF-kappaB in human MM cells, leading to the suppression of proliferation and induction of apoptosis, thus providing the molecular basis for the treatment of MM patients with this pharmacologically safe agent.”

Please click the link below to see watch a 5 minute video citing how curcumin stops MGUS from becoming Multiple Myeloma.

Turmeric Curcumin, MGUS, and Multiple Myeloma

The Most BioAvailable Curcumin Formulas

“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”

A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.

I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.

The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.

The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.

Recommended Reading:

Curcumin

“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.[1]“

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.

“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.

The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.

Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.

Based on the published reports,

exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”

According to Consumerlab.com:

“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”

 

 

Leave a Comment:

21 comments
Marianne roote says last year

David , I was diagnosed with Mm in 2021.i had broken a disc in my back and had it fused .I would love to gind out more about the diet. I want to survive as long as possible. Marianne

Reply
    David Emerson says last year

    Hi Marianne-

    I sent the nutrition guide to you via email.

    Hang in there,

    David Emerson

    Reply
MGUS, Bone, Scan... - PeopleBeatingCancer says last year

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Whole-Body Hyperthermia - Smoldering Myeloma... - PeopleBeatingCancer says a couple of years ago

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Can MGUS Kill You? - PeopleBeatingCancer says 3 years ago

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Reply
reynaldo nisperos says 3 years ago

Which one of these supplements is oxalate free w/ no danger of kidney stones?

Reply
    David Emerson says 3 years ago

    Hi Reynaldo-

    I don’t know.

    David Emerson

    Reply
Arthritis, Joint Pain MGUS Symptom, Therapies - PeopleBeatingCancer says 3 years ago

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MGUS and Genetic Risk of Progressing to Multiple Myeloma - PeopleBeatingCancer says 6 years ago

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Gysemberg Annemieke says 6 years ago

I am 60 years old and mgus from 2014…now at 3467… what can I do to stay as healthy as possible without any pain…lots of pains and infections lately …very difficult indeed…

Reply
    David Emerson says 6 years ago

    Hi Gysemberg,

    I am sorry to learn of your pains and infections. Several things. When you say “now at 3467” I take you to mean that this number is one of your Free Light Chain numbers? Kappa or Lambda? Do you know your monoclonal protein or m-spike? When you refer to pains are you experiencing bone pain? When was the last time you had some sort of imaging test? X-ray, PET, MRI, etc?

    I don’t mean to sound nosey. I’m just trying to understand your current status.

    To answer your question, there are several evidence-based, non-toxic therapies cited to kill MM. Curcumin, resveritrol, others. The pre-MM cancer coaching program include 7 guides that outline evidence-based, non-toxic therapies for the MGUS, SMM patient.

    The Basic Pre-MM CC package will contain the 7 guides that I am refering to.

    If your MGUS has progressed to full-blown MM we can discuss how you would like to proceed (chemo or no, etc.)

    Let me know if you have any questions.

    David Emerson

    Reply
Linda Steier says 7 years ago

I was diagnosed last year with MGUS. I have 1 % increase each year. I have stopped eating meat, dairy,sugar as much as possible, I try to stay away from gluten. I went to see Dr. ColBert who put me on a bunch of vitamins including bio-Curcumin. I was at 1.7proteins now one year later I am at 2. I need your help. How much Curcumin should I be taking?

Reply
    David Emerson says 7 years ago

    Hi Linda-

    I am sorry to read of your MGUS diagnosis. Your daily dose of Life Extension’s Super BioCurcumin (if that is correct) can vary. Meaning I know of active MGUS patients taking between one capsule (400 milligrams) and 8 GRAMS. 1000 milligrams = 1 gram.

    I am a long-term MM survivor and MM cancer coach. I work with MGUS, SMM and MM patients to manage their pre-cancer or cancer. MGUS is considered to be pre-cancer, not MM yet. You are correct. Your risk of progressing to full-blown multiple myeloma is approximately 1% annually.

    While curcumin has been shown to down-regulate a specific protein in MGUS patients, it is only one of several evidence-based MGUS therapies. The MGUS Cancer Coaching Program is comprised of six guides providing evidence-based, anti-MGUS nutrition, supplementation, bone health, detox/exercise, cannabis and mind-body therapies.

    All based on research, all non-toxic.

    Your m-spike is currently 2.0. Are you experiencing any other symptoms such as bone pain, nerve pain or kidney damage? How old are you? I don’t mean to be nosey. I am just trying to understand your health status.

    Thanks and hang in there,

    David Emerson

    Reply
Adrienne says 7 years ago

I have MGUS plus advanced osteoporosis at age 70. My osteoporosis is getting worse, even with curcumin, d3, vitk, magnesium, manganese etc. I am just starting vibration machine plus bonedensity machine. Not sure if PEMF mat would be good to try as well. Do you have any information or suggestions as to if any of these help and what actually works? My doctor says I HAVE to take Forteo or some type of drug. Help!!!

Reply
    David Emerson says 7 years ago

    Hi Adrienne-

    I am sorry to read of your MGUS and osteoporosis. Several things for you to consider.

    Even though MGUS is considered to be asymptomatic aka with NO symptoms, it is common for an MGUS patient to experience one or more symptom such as bone pain, nerve pain, blood clots (DVT), kidney damage, skin rashes and rarer symptoms. In short, monoclonal proteins, even a small about, can cause symptoms.

    While I am sure that your supplementation with curcumin, mag. etc. are increasing your bone density, the MGUS is reducing your bone density at an even faster rate than you are building bones.

    I agree with your doctor- conventional bone therapy is needed. A bisphoshonate therapy that is standard of care for myeloma patients should be considered for you. Bisphosphonate both solidify bones as well as have an anti-MM effect. Please ask your doctor about this.

    I encourage you to continue with frequent, moderate bone building exercise, bone building nutrition, etc.

    Do you know what your monoclonal protein aka m-spike is currently? When were you first diagnosed with MGUS?

    David Emerson

    Reply
    Cait Himmel says 3 years ago

    Hi Adrienne, curious if you ever got an answer about MGUS and PEMF. I similarly am considering a PEMF machine. I have MGUS and a few other conditions (Lyme Disease, etc.)

    Reply
Larry says 7 years ago

Yes I am taking tumeric curcumin, ginger and Holy Basil an thinking of adding the following:
Reseveratrol, Quercetin ?

What are ? foods that starve multiple myeloma ?

What are 16 non-toxic, cytotoxic/apoptotic supplements ?

I am not overweight and work out. I listened to the video but did not hav a chance to write down all the Supplements

Reply
    David Emerson says 7 years ago

    Hi Larry-

    Yes, curcumin, ginger have been shown to reduce a protein in MGUS, reducing your risk of MM. The list of supplements are those I have researched from multiple myeloma not MGUS. While I believe the biological mechanism are common to both MGUS and MM I cannot point to a study that proves this. Yes, quercitin and resveritrol are on this list as anti-MM supplements.

    I just wrote a blog post about MPV and MGUS. 70% of MGUS patients have the HPV virus. While this virus will clear itself over the next few years a supplement called AHCC has been shown to get rid of the HPV virus. That is the brand that I used.

    Keeping your weight normal is good. Or should I say that overweight causes inflammation which is a precursor to MM. Likewise frequent, moderate exercise. The foods again, are those I have researched for MM not MGUS.

    The only other non-toxic therapies that I recommend for MM and MGUS patients are the dozen bone health supplements that are listed in the bone health guide and evidence-based, mind-body therapies. Fracture risk is several times higher in MGUS patients. Again, weight bearing exercise helps build bone density.

    If you live in a state that has legalized cannabis you should consider supplementing with CBD oil.

    Let me know if you have any questions.

    David Emerson

    Reply
      Ed Drake says 5 years ago

      David, my oncologist says I have plasma cell dyscrasia. As far as I can find out that is the same as MGus. What dose of CBD would you suggest and what other supplements? Can you give me a list with doses? Thank you so much for caring and for your help. – Ed

      Reply
        David Emerson says 5 years ago

        Hi Ed,

        Plasma cell dyscrasia is the general family of blood disorders for MM, MGUS, SMM- The next step is to determine your degree or amount of PCD- how advanced your PCD is. If your m-spike or monoclonal protein is under 3.0, you have pre-MM, MGUS or SMM. The pre-MM cancer coaching program contains evidenced-based, non-toxic therapies to reduce your risk of a full-blown MM diagnosis.

        https://peoplebeatingcancer.org/product-category/pre-myeloma/

        “Plasma cell dyscrasias are a heterogeneous group of disorders caused by the monoclonal proliferation of lymphoplasmacytic cells in the bone marrow. Multiple myeloma is the most serious and prevalent plasma cell dyscrasia”

        CBD oil has been shown to ba antiangiogenic and is integrative or synergizes with Velcade (a MM chemotherapy regimen). There has not been enough research done as to whether CBD actually is cytotoxic (kills) MM. To answer your question about CBD dosing, first find a strain of CBD oil with a high percentage of cannbinoids. Most MMers think a small percentage of THC is most efficatious for killing MM but as I said, it is still an open question as to whether or not CBD kills MM.

        Once you find a CBD oil with a high percentage of cannabinoids ( I will link a blog post with the names of several high percentage strains below), when you are ready to take your first dose (most people recommend dosing before bed in case you feel tired) simply put several drops under your tongue.

        The idea is to start slowly and to increase your daily dose in an effort to see how you respond.

        5 High Cannabinoid Percentage C-B-D Oil Strains for Multiple Myeloma

        My point is that while research into CBD oil has concluded that CBD can reduce pain, reduce anxiety, build bones, others, research has not confirmed efficacy of MM cytotoxicity. My advice to you is to consider the evidence-based, non-toxic therapies in the Pre-MM CC program. For example, curcumin has been shown to be cytotoxic to MM.

        Let me know if you have any questions.

        David Emerson

        Reply
Newly Diagnosed MGUS Explained says 7 years ago

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