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MGUS Increases the Risk of Blood Clots

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Monoclonal Gammopathy of Undetermined Significance- Asymptomatic, Pre-Myeloma Blood Disorder that can Increase Susceptibility to Deep Vein Thrombosis aka Blood Clots

Have you been diagnosed with Monoclonal Gammopathy of Undetermined Significance? Are you experiencing bone pain, nerve pain and/or exhaustion? While monoclonal gammopathy of undermined significance (MGUS) is supposed to be “asymptomatic” meaning it does not come with symptoms, MGUS patients can experience a variety of health problems. Getting a blood clot can be serious.

MGUS at a glance-

To learn more about the evidence-based protocols you can follow to prevent your Pre-Myeloma from becoming Multiple Myeloma, please watch the short video below:

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Threatening clots in MGUS and myeloma

“In this issue of Blood, Kristinsson and colleagues report an increased risk of venous and arterial thrombosis in MGUS and multiple myeloma in a population-based study including 18 627 patients with multiple myeloma, 5326 patients with MGUS, and 70 991 controls.1


Thrombosis usually is associated with disruptive symptoms, may lead to a postthrombotic syndrome, and can sometimes become life-threatening (see figure)…

In addition, several other new findings in the MGUS cohort are notable. Thrombosis in MGUS was associated with increased mortality but not with transformation to multiple myeloma. This indicates that the underlying premalignant process activates biological pathways, putting the affected person with MGUS and thrombosis at a higher risk for mortality

Only patients with an IgG or IgA isotype, but not those with an IgM paraproteinemia, were at increased risk for thrombosis.”

Hypercoagulability in multiple myeloma and its precursor state, monoclonal gammopathy of undetermined significance.

“Several studies have shown that patients with multiple myeloma precursor disease (monoclonal gammopathy of undetermined significance [MGUS]) also have a higher risk of thrombosis compared to the general population…”

Consider MGUS Therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve multiple myeloma
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. Non-conventional bone health therapies
  6. Cannabis/CBD/THC oil

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer



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