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Diagnosed with SMM, SPB, or MGUS?

Learn how you can stall the development of full-blown Multiple Myeloma with evidence-based nutritional and supplementation therapies.

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MGUS – Nerve Pain

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Peripheral Neuropathy (PN) as Symptom of Monoclonal Gammopathy of Undetermined Significance.

Four statistically significant differences set IgM-MGUS neuropathies apart from IgG-MGUS and IgA-MGUS neuropathies:

(1) higher frequency of sensory loss and ataxia,

(2) higher frequency of nerve conduction abnormality–10 attributes were significantly worse (none were significantly better),

(3) higher frequency of dispersion of the compound muscle action potential, and

(4) higher frequency of IgM-MGUS in the MGUS neuropathy cohort that is characteristic of MGUS without neuropathy seen at our institution or that is encountered in epidemiological surveys…”

Monoclonal Gammmopathy of Undetermined Significance at a glance- click the illustration below:

Hi. My name is David Emerson. I am a long-term survivor of multiple myeloma (MM) and a MM cancer coach. If you’re reading this post, my guess is that you have been wondering about both your diagnosis of monoclonal gammopathy of underdetermined significance as well as a symptom of MGUS called Peripheral Neuropathy (PN).

Suffice to say that pre-myeloma is a little known and less-well understood blood disorder. It is not cancer. It is “pre-cancer” or “pre-myeloma.”  And yes, though MGUS is referred to as being “asymptomatic” aka without symptoms, MGUS patients can sometimes experience nerve pain.

Yes, this blood disorder can lead to a diagnosis of Multiple Myeloma but I’ll get to that later.

Your challenge is that conventional oncology does not treat blood disorders. Your oncologist may have told you to “watch and wait” regarding your MGUS. Your first step then is to read the studies linked and excerpted below in an effort to understand your condition and then communicate with me about possible evidence-based, non-conventional therapies to reduce your risk of a full-blown multiple myeloma diagnosis.

I have remained in complete remission from MM since 1999 by living an evidence-based, non-toxic, anti-MM lifestyle through

  • nutrition,
  • supplementation,
  • bone health therapies,
  • detoxification, and
  • mind-body therapies.

I’m telling you this not to introduce you to the virtues of therapies like acupuncture, essential oils or yoga, I am telling you this in an effort to explain how beneficial non-FDA approved therapies can be to MM and MGUS patients.

To learn more about the evidence-based protocols you can follow to prevent your Pre-Myeloma from becoming Multiple Myeloma, please watch the short video below:

Learn about MGUS therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve multiple myeloma
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. Non-conventional bone health therapies
  6. Cannabis/THC oil

Have you been diagnosed with Monoclonal Gammopathy of Undetermined Significance? Do your feet hurt aka nerve pain? Please scroll down the page, post a question or comment and I will reply ASAP.

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Neuropathy associated with monoclonal gammopathies of undetermined significance.

” Four statistically significant differences set IgM-mono neuropathies apart from IgG-mono and IgA-pre-myeloma neuropathies: (1) higher frequency of sensory loss and ataxia, (2) higher frequency of nerve conduction abnormality–10 attributes were significantly worse (none were significantly better), (3) higher frequency of dispersion of the compound muscle action potential, and (4) higher frequency of IgM-MGUS in the MGUS neuropathy cohort that is characteristic of MGUS without neuropathy seen at our institution or that is encountered in epidemiological surveys…”

Polyneuropathy associated with monoclonal gammopathy of undetermined significance: further evidence that IgM-MGUS neuropathies are different than IgG-MGUS.

“We evaluated the clinical characteristics and electromyographic features of 39 patients with monoclonal gammopathy of undetermined significance and neuropathy…

  • 23 had a monoclonal IgM protein
  • 13 had a monoclonal IgG protein
  • 3 had a monoclonal IgA protein

Comparing IgM and IgG neuropathies, we found the following differences: (1) There was a statistically significant higher frequency of sensory loss in the IgM group. (2) Nine attributes of nerve conduction abnormality were statistically worse in the IgM group, with slowing of conduction velocities and prolonged distal latencies. (3) The frequency of monoclonal IgM was overrepresented in the MGUS neuropathy group…”

If you do not want to “watch and wait” to see if your pre-myeloma progresses to Multiple Myeloma click the blue button below to watch a FREE webinar about managing MGUS to prevent Multiple Myeloma:

 

Leave a Comment:

41 comments
Multiple Myeloma Stage 1- Bone Health? - PeopleBeatingCancer says a few months ago

[…] Monoclonal Gammopathy of Undetermined Significance (MGUS) Nerve Pain […]

Reply
Single Plasmacytoma vs. Multiple Myeloma - PeopleBeatingCancer says a few months ago

[…] Monoclonal Gammopathy of Undetermined Significance (MGUS) Nerve Pain […]

Reply
Terri A says 6 months ago

I was diagnosed MGUS after routine yearly bloodwork identified an elevated protein in my blood.
After more specific bloodwork, bone scans and full body MRI tests, my hematologist confirmed the diagnosis. I followed up three months later and then six months later and all has been status quo with a couple of elevations. I began to research online and came across your site. Thank you for sharing. I would love to “watch and learn” more about my diagnosis.

Reply
    David Emerson says 6 months ago

    Hi Terri-

    I am sorry to read of your MGUS diagnosis. It sounds as though you are low risk and stable at this time. All good. Do you have any symptoms such as bone or nerve pain? Does everything feel AOK with you?

    David Emerson

    Reply
NIRA FRIED HIRSHENBERG says last year

I am very sorry dear David,but I cann’t understand a word when listening to your videos.it is sooo blured,My english is good;even more then just good,but I cann’t understand your speech.something is wrong with whoever recorded you.I really wanted to register to your lessons,but I am affraid to do so,because if the quallity of voice is the same as in these videos,I will hardly understand a whole sentance,and I will be throughing away my money.if there is an option to have your lectures in written instad of spoken I might give it a chance,otherwise I will have to give it up ,unwillingly

Reply
Virginia Garcia says last year

I have mgus, lupus and Sjogrens. I am very worried

Reply
    David Emerson says last year

    Hi Virginia-

    Registering for the Pre-MM CC Program-Course and Consultation is an important first step in managing your health challenges. Please reply to my email asking about your:

    goals,
    symptoms,
    any therapies that you have had
    any questions you have

    I will ask you to send me your latest diagnostic testing results such as your Complete Blood Count, Metabolic panel, Freelight chain assay, SPEP, Bone Marrow Biopsy, FISH analysis, etc.

    I sent that email to you yesterday. Let me know, thanks.

    David Emerson

    Reply
Detoxification as Multiple Myeloma Therapy - PeopleBeatingCancer says last year

[…] Monoclonal Gammopathy of Undetermined Significance (MGUS) Nerve Pain […]

Reply
Smoldering Multiple Myeloma- KRD or Non-conventional? - PeopleBeatingCancer says a couple of years ago

[…] Monoclonal Gammopathy of Undetermined Significance (MGUS) Nerve Pain […]

Reply
Mark says a couple of years ago

Thank you for all of the information! I been living with severe foot, nerve and bone pain that has progressively gotten much worse. I have to use a wheelchair if I have to stand for more than 10-15 minutes. I was just recently informed I have igg MGUS. I also recently broke out in a rash of my torso. I’ve also had some nerve conduction study which revealed nerve damage. I have recently been nauseous the last week. Any advice or comments would be very much appreciated. Thank you very much!!

Reply
    David Emerson says a couple of years ago

    Hi Mark,

    MGUS is difficult to diagnose and conventional oncology considers MGUS to be asymptotic and a blood disorder, not cancer. You can reduce your risks of a full-blown MM diagnosis with evidence-based but non-toxic therapies in the pre-MM program.

    https://peoplebeatingcancer.org/product-category/pre-myeloma/

    Let me know if you have any questions.

    David Emerson

    Reply
Low But Persistent Risk of MGUS - PeopleBeatingCancer says 3 years ago

[…] Monoclonal Gammopathy of Undetermined Significance  Nerve Pain […]

Reply
Can MGUS Spur Non-Melanoma Skin Cancers? - PeopleBeatingCancer says 3 years ago

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MGUS Screening? - PeopleBeatingCancer says 4 years ago

[…] Monoclonal Gammopathy of Undetermined Significance (MGUS) Nerve Pain […]

Reply
Sheila Dade says 4 years ago

I want to find some reasons why I have this and want to treat this agressively rather than sit and wait! I am being followed at Emory Hospital and want a second opinion. Please respond and give me some guidance! I get copies of my blood work but they never tell me the progression of the M protein! I have been told that my numbers look good! I want to live a toxic free life and want to change my eating habits. But I am not getting guidance in this area. I feel like a sitting duck!!!! I have a poor understanding of it all and feel like my doctor wants me as a science project!
keep me in the dark!

Reply
    David Emerson says 4 years ago

    Hi Sheila,

    I am sorry to read about your MGUS diagnosis. Keep in mind that many people live with this form of “blood disorder” for years without knowing it and die of old age. Yes, MGUS can evolve into frank multiple myeloma but there are evidence-based, non-toxic therapies that reduce the risk of full-blown MM.

    “The progression of m-protein” occurs only over time, based on how often you have blood work done. Regarding your desire to live a “toxic free life,” you can do this and reduce your risk of progressing to MM. The “pre-MM” program is a series of evidence-based therapies that reduce your risk of MM. The program is inexpensive and easy to follow. I do/take each of the therapies myself and have for years.

    The reason why MGUS or SMM patients don’t get guidance in this area is that MGUS is a blood disorder and not cancer. Drug companies invent therapies for cancers usually. Further, the studies that support these therapies are not clinical controlled studies.

    Please click the link below to learn more- let me know if you have any question.

    pre-myeloma cancer coaching products-

    Let me know if you have any questions.

    David Emerson
    MM Survivor
    Director PeopleBeatingCancer

    Reply
Paula Bourne says 4 years ago

Hi David
I was diagnosed MGUS around 5 years ago.
Never really worried to much about it. My paraprotein has hovered around 6-7, and they said if it continued to rise as it was i wouldnt get MM till around the age of 90 (im now 47) Last month my paraprotein had gone up to 10, which I know isnt his high, but my feet are getting worse. Feel like im walking on wet sponges and started to get a lot of pain in my left foot. I also get a lot of pelvic and back pain, not really bad but lingers for a couple of days at a time.
All my other blood work has been unremarkable.
Just wondering if you think my pain is related to MGUS

Kind regards

Paula

Reply
    David Emerson says 4 years ago

    Hi Paula-

    Though MGUS is considered to be “asymptomatic” by conventional oncology, it often comes with well-documented symptoms such as nerve and bone pain. You are correct that if your numbers are okay you can remain in pre-MM but your quality of life suffers. To answer your question, yes, your pain is related to MGUS.

    David Emerson

    Reply
Simon says 4 years ago

Hi David, I would like to know is this the way of things regarding pain, I was diagnosed with MGUS in 2012 for the last 2 years i have been experiencing bouts of neuropathic nerve pain. First starting in my shoulder blades then into arms, hands and now on the one side of face, legs and feet Sometimes the pains feels like a aching, lightening pain, quick and sharp, especially in the palms of my hands and face. I was told that i have neuralgia and fybromalgia as well as raised SHBG levels i’m also allergic to many verity of foods which I have had for many years. I’ve now requested a follow up for my bloods to be done, hopefully my MGUS has not progressed further.

Reply
    David Emerson says 4 years ago

    Hi Simon-

    You have been diagnosed with several possibly overlapping issues all of which may be contributing to your pain. I will address
    as many possibilities as I can.

    Re nerve pain and MGUS. As you know, MGUS is supposed to be asymptomatic aka you are supposed to have any nerve pain. However pain as a possible MGUS symptom is well documented. Further, nerve pain is well documented for fibromyalgia as well. Also as you probably know, conventional oncology considers MGUS to be a “blood disorder” and therefore can offer no therapies.

    My experience is for pre-MM patients (single plasmacytoma, MGUS and SMM) to pursue evidence-based, non-toxic therapies. Several of the therapies I take as a long-term MM survivor overlap with supplements that I have read about helping fibromyagia- an example would be vitamin D3- I take this for bone health and balance and I will link a study below about fibromyalgia.

    Please consider the pre- MM cancer coaching program. The information provided will has been shown to reduce your risk of progressing to MM and I have worked with MGUS patients who tell me that they have slowly reduced their m-spike.

    Basic Pre-MM CC Program-

    Treating Fibromyalgia Pain Naturally

    Let me know if you have any questions. Hang in there,

    David Emerson

    Reply
Heather Nelson says 5 years ago

So interesting I would read this. Yes, I have been having pain in my feet, and tingling in my hands. I was diagnosed about 8 years ago, never progressed, praise God. I went immediately on curcumin, no thanks to my Johns Hopkins doctor, who dismisses my curcumin use, still after 8 years. He also says there is NO LINK to my nerve pain and my MGUS. I have been having tests, and am due to see a rheumatologist soon. I also have brain fog, and memory issues. Again, I have never had Chemo. I live in the country of Panama, and we work with deaf indigenous children. (which I adore) I return to the states for blood tests at Hopkins every 6 months, and they are just waiting for me to warrant Chemo, with no further advice. I have gotten complacent with my diet and health, with no support from my doctor. Next tests are in October, Always apprehensive…….

Reply
    David Emerson says 5 years ago

    Hi Heather-

    I admit that I like to prove conventional oncology wrong- or at least I like to prove to them that they don’t have all the answers. Not having all the answers is the reason why PeopleBeatingCancer has a place in this word.

    Living outside of the US may make you out of touch where MGUS is concerned. Let me know if you have any questions.

    David Emerson

    Reply
Gene says 5 years ago

David,
Recently had onslaught of full body PN. While I’ve known that I had mild PN since about 3 years ago it was so mild that diagnosis was result of testing for another issue. Then at the end of May this year I went from tingling in my fingers to full body PN within a week. Really horrible tingling, pins and needles and burning sensation over entire body.

Testing revealed IgG m spike – lambda monoclonal protein present of 0.3 G/DL. Gamma Region. All other regions were within normal ranges. Immunogloglobulin G, A and M all within normal ranges. Testing for POEMS was negative. I then went to a functional medicine doctor and testing revealed high sensitivities to wheat, gluten, milk and certain fish. Going to see a hematologist and a new neurologist (first one indicated to just take pregabalin). What questions should I be asking to get a response other then “watch and wait”? Any other suggestions?

Reply
    David Emerson says 5 years ago

    Hi Gene-

    Several issues for you to consider. Based on your email my guess is that you have MGUS. This is a blood disorder, not cancer. Yes, mgus may progress to frank multiple myeloma but you are pre-MM. As you probably know, MGUS is usually asymptomatic. There are documented cases however, of PN, kidney involvement, etc.

    To answer your question about anything more to do other than watch and wait, two things. I encourage you to ask your oncologist to confirm that you have no other MM symptoms. Yes, an m-spike of .03 is tiny. This is good. However, please have your kidney function tested, perhaps imaging studies to confirm no other “hot spots” and any other testing that your oncologist would do with frank MM.

    Secondly I would consider evidence-based, non-conventional therapies shown to reduce the risk of MGUS progressing to full blown MM. I work with MGUS patients who have lowered their m-spike and I know of two pre-MM survivors who have been living with pre-MM for more than 15 years now.

    Mary, one of the MGUS survivors, talked about severe nerve pain before she knew she had pre-MM.

    I do not know if or how your food sensitivities might be affecting your pre-MM.

    I will send you the link to the pre-myeloma cancer coaching package after I finish this reply. Let me know if you have any questions.

    David Emerson

    Reply
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