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Pre-myeloma, MGUS and Fracture Risk-

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Monoclonal Gammopathy of Undetermined Significancer (MGUS) is a blood disorder, not cancer with a higher-risk of bone damage/fractures-

While conventional oncology considers all forms of pre-Myeloma to be “asymptomatic” as the studies linked and excerpted below explain, many MGUS patients experience symptoms such as bone pain, nerve pain and fractures.

MGUS at a glance-

My name is David Emerson. I am a long-term myeloma survivor and multiple myeloma cancer coach. I am writing about MGUS for two main reasons. First, because people who are diagnosed with MGUS are often told to “watch and wait.” And second,  22 plus years surviving multiple myeloma has taught me that there are many evidence-based, non-toxic therapies that MGUS/SMM/MM patients can pursue on their own.

To learn more about how to alleviate bone pain, along with other evidence-based therapies that can help you prevent the development of a Multiple Myeloma diagnosis, please watch the short video below:

 

Have you been diagnosed with MGUS or some other form of pre-MM? Are you experiencing bone pain? Scroll down the page, post a comment or a question and I will reply to you ASAP.

Consider MGUS Therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve growing blood blood vessels
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. Non-conventional bone health therapies

To Learn More about Monoclonal Gammopathy of Undetermined Significance (MGUS)- click now 

Thank you,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Fracture risk in monoclonal gammopathy of undetermined significance

“There was a 2.7-fold increase in the risk of axial fractures but no increase in limb fractures…

Altogether, 200 patients experienced 385 fractures. Compared with expected rates in the community, statistically significant increases were seen for fractures at most axial sites, for example, vertebrae…

In a multivariate analysis, the independent predictors of any subsequent fracture were

  • age per 10-year increase,
  •  corticosteroid use;
  • greater weight at diagnosis,
  • and IgG monoclonal protein were protective.

Baseline monoclonal protein level, a determinant of myeloma progression, did not predict fracture risk.

Less strength and more fractures for MGUS bones

“In this issue of Blood, Farr et al showed that patients with monoclonal gammopathy of undetermined significance (MGUS) have increased cortical bone porosity and reduced bone strength,1 conditions that can lead to the increased fracture risk, which has been reported in MGUS patients…

The International Myeloma Working Group (IMWG) also suggests bisphosphonates in all MGUS patients with proven osteopenia or osteoporosis.9 Indeed, bisphosphonates increase bone strength through decreasing bone turnover…”

Understanding Bone Disease and Fractures in Patients With MGUS

“While individuals with MGUS had normal bone-mineral density (BMD), their bone volume was increased compared to patients without MGUS. In addition, men with MGUS had an almost 50% increased risk of fractures, compared with other men. “Our findings suggest an effect of MGUS on bone metabolism that does not affect BMD,” the authors wrote of the findings.

In this cohort study, the researchers screened for MGUS in more than 5,000 older Icelandic participants included in the Age, Gene/Environment Susceptibility–Reykjavik Study (AGES-RS), and measured bone metabolism (BMD and bone volume), as well as subsequent fracture risk, over a median of 6.9 years of follow-up (range = 0-11.3 years). BMD and bone geometry were evaluated using quantitative computerized tomography (QCT) in the lumbar spine and the left hip with a four-row detector CT system…

During follow-up, 1,334 fractures were recorded: 74 in the MGUS group (34 in men and 40 in women) and 62 in the LC-MGUS group (19 in men and 43 in women). The risk of fracture was not significantly increased in those with MGUS or LC-MGUS, compared with other AGES-RS participants, but was increased for men with MGUS, compared with other men (hazard ratio [HR] = 1.49; 95% CI 1.03-2.08).

The researchers again noted an unexpected finding: Women with and without MGUS had similar risks of bone fracture (HR=1.02; 95% CI 0.74-1.40). “This suggests an effect of MGUS on bone metabolism in men that is not noted in women, possibly as a result of other stronger risk factors in postmenopausal women,” they wrote, explaining that the generally enhanced rate of bone loss in women with osteoporosis “may mask the effect of MGUS on bone metabolism.”

Eighteen patients with MGUS progressed to MM during follow-up, four of whom had a fracture before progression (2 men and 2 women). In addition, patients with MGUS who developed fractures had a decreased BMD at the spine (p<0.001), femoral neck (p=0.005), trochanter (p<0.001), and total hip (p<0.001), compared with others with MGUS, “indicating that processes known from osteoporosis play a role in fractures in this group, just like in the general population,” the researchers noted.

Overall, though, the risk of fractures had no significant association with the risk of progression to MM, compared with patients with MGUS without fractures (HR=0.77; 95% CI 0.24-2.47).

“Our results do not support measuring BMD in [patients with] MGUS to screen for osteopenia/osteoporosis, as our study shows that they do not have a lower BMD than others in the same age group,” the authors concluded. “Studies are needed to determine how patients with MGUS with increased risk of fractures can be identified and how and if they should be treated prophylactically…”

 

Leave a Comment:

13 comments
MGUS - Diagnosis - PeopleBeatingCancer says a couple of years ago

[…] Pre-Myeloma – MGUS and Fracture Risk […]

Reply
SMM, MGUS, Fibromyalgia, Neuralgia? - PeopleBeatingCancer says 3 years ago

[…] Pre-myeloma, MGUS and Fracture Risk- […]

Reply
Risk of Progression of MGUS to Multiple Myeloma Can Rise Over Time - PeopleBeatingCancer says 5 years ago

[…] Pre-myeloma, MGUS and Fracture Risk- […]

Reply
Can MGUS Patient Predict Progression to Multiple Myeloma? - PeopleBeatingCancer says 5 years ago

[…] Pre-myeloma, MGUS and Fracture Risk- […]

Reply
Susanna says 5 years ago

I was told over a year ago that I have Paraprotein anemia M(GUS) and neuropathy which I was diagnosed with 4 years ago. This is all very confusing for me. Last spring I cracked a rib the 6th one whatever that is, but I deal with bone pain on almost a daily basis, and the pain in my left leg keeps me up most nights. Exactly what is this?

Reply
    David Emerson says 5 years ago

    Hi Susanna,

    I’m sure that your confusion and pain is…painful and frustrating. I wrote that blog post because many pre-MM patients like you contact me to say that their pre-MM (MGUS) is hurting them.

    I can’t answer your question without seeing your blood work. I’m assuming you have blood diagnostics. If your m-spike is below 3.0 you have probably been told that you are pre-MM and therefore there is no treatment. This is not true.

    One step at a time. Can you email me the results of your blood testing? My email address is David.PeopleBeatingCancer#gmail.com

    Let me know.

    Hang in there.

    David Emerson

    Reply
Diagnostic Testing for MGUS - PeopleBeatingCancer says 5 years ago

[…] Pre-myeloma, MGUS and Fracture Risk- […]

Reply
Wait for Pre-Myeloma to Progress or Try Non-Conventional Therapies? - PeopleBeatingCancer says 6 years ago

[…] Monoclonal Gammopathy of Undetermined Significance (pre-myeloma) and Fracture Risk- […]

Reply
Jessica Kalusokoma says 6 years ago

Hi. My sons dad was diagnosed with pre myeloma. Could you please suggest any natural remedies to help him out. They says if he goes on treatment, he might not be able to have kids.

Reply
    David Emerson says 6 years ago

    HI Jessica-

    The pre-MM cancer coaching program was designed to provide evidence-based, non-toxic therapies for the pre-MM patient like your son’s dad. The basic program is inexpensive as well. Let me know if you have any questions. Keep in mind that it comes with a money-back guarantee.

    Pre-MM cancer coaching program-

    David Emerson

    Reply
Anne Wallace says 7 years ago

I was diagnosed with multiple myeloma January 2016. I have completed my first round of chemo this January. I received Velcade by subcutaneous injection, oral Dexamethesone and oral Cyclophosphamide weekly for 45 weeks. Treatment ended early January this year. To date I have resisted Pamidronate infusions for bone damage as I have concerns regarding major side effects.

I am interested in now taking natural supplements to try and maintain the remission period as long as possible. I have read your comments with great interest and would greatly appreciate any advice you would be prepared to offer. I have read about Quercetin, circumin and bromelian.

Sincerely

Reply
    David Emerson says 7 years ago

    HI Anne- I will reply to you via your email so I can include a pdf file. David

    Reply
    David Emerson says 7 years ago

    Hi Anne-

    My email bounced back. Please email me at david.peoplebeatingcancer@gmail.com so I can send the bone health pdf.

    I am sorry to learn of your MM diagnosis. CyBorD (cytoxan, velcade dex.) is, according to studies, an effective induction chemotherapy triplet. So that I am clear on your current situation, are you saying that you underwent your induction therapy during 2016 but you did not undergo bisphophonate (pamidronate) therapy?

    I am attaching the bone health cancer coaching guide. You will see that there is a fair amount that you can do on your own to strengthen your bones.

    Regarding evidence-based, non-conventional, MM therapy, yes, studies support anti-MM nutrition, supplementation, lifestyle and other therapies.

    Do you know your current MM status? Complete remission? Do you know what your M-spike is? Are you experiencing any side effects of the CyBorD therapy such as nerve pain or bladder pain?

    I don’t mean to sound nosey. The more I know, the more info I can offer.

    Let me know, thanks.

    David Emerson
    MM Survivor
    MM Cancer Coach

    Reply
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