Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission
Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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“In this report we show that hyaluronan (HA), a major nonprotein glycosaminoglycan component of the extracellular matrix in mammalian bone marrow, is a survival and proliferation factor for human myeloma cells.”
Hi David- A naturopath told me that hyaluronic acid is a multiple myeloma cell accelerant or activator. I was told to not take bone broth, collagen, and bone broth protein.
This kills a great source of bone and joint promoters that I need! Plus a muscle builder with the added protein. Do you know this to be true? Thank you!! JJ-
Hi JJ-
Your post and question make a good but difficult point for me. According to the study linked below, yes, hyaluronic acid “induces survival and proliferation” of MM cells.
My challenge is that I have been stirring collagen powder into my juice every morning for several years now. And I continue to remain in complete remission from my MM according to annual SPEP testing.
To complicate things, much of the reason for my collagen supplementation is my MM history being filled with bone involvement. In other words, I was one of those MM patients who had lots of serious bone damage. Think swiss cheese sized holes in my bones.
Needless to say, I have focused on my bone health over the past 20 plus years in an effort to make my bones as solid and strong as could be. It didn’t help when my mom fell two years ago causing a break in her hip. Like many 80 plus folks, a broken hip began a slow downward spiral in my mom’s mental and physical health.
Not to be dark or maudlin, I’m simply saying that:
exercise,
protein supplementation,
clean eating,
nutritional suppelementation, etc.
are many forms of lifestyle therapies shown to be anti-MM and pro-health and are important to me. I pursue an anti-MM lifestyle and I am doing well as a MM survivor.
Frankly JJ, I don’t know what to do with your post. I do believe the study below but I’m not going to stop my morning collagen supplementation. Or at least I need to know more about both collagen and HA. I don’t do bone broth so that’s not an issue.
I believe strongly that maintaining my bone and joint health is important for me.
So to answer your question “Do you know this to be true?” Yes, according to the study below, HA spurs MM cell growth. What I can figure out is the specific relationship between HA and collagen. The article below seems to imply that they are two separate substances in the body.
Please ask your naturopath if HA is in collagen or if I supplement with collagen, am I also supplementing HA? I would like to continue to supplement with collagen. I don’t really mind if my skin continues to wrinkle. Don’t misunderstand me, I am as vain as the next person however, I am way beyond caring much about how I look…
“Originating from a post-switch memory B cell or plasma cell compartment in peripheral lymphoid tissues, malignant myeloma cells accumulate in the bone marrow of patients with multiple myeloma. In this favorable microenvironment their growth and survival are dependent upon both soluble factors and physical cell-to-cell and cell-to-extracellular matrix contacts.
In this report we show that hyaluronan (HA), a major nonprotein glycosaminoglycan component of the extracellular matrix in mammalian bone marrow, is a survival and proliferation factor for human myeloma cells.
The effect of HA is mainly mediated through a gp 80-interleukin 6 (IL-6) receptor pathway by a CD44-independent mechanism, suggesting that HA retains and concentrates IL-6 close to its site of secretion, thus favoring its autocrine activity.
In addition, we show that HA-mediated survival and proliferation of myeloma cells is associated with a down-regulation in the expression of p27(kip1) cyclin-dependent kinase inhibitor and a hyperphosphorylation of the retinoblastoma protein (pRb).
These data suggest that HA could be an important component in the myeloma cell physiopathology in vivo by potentiating autocrine and/or paracrine IL-6 activities.
“Collagen and hyaluronic acid are compounds in your skin and other connective tissues. Hyaluronic acid is needed to bind collagen with elastin, which are fibers that give your skin its stretch. Your body naturally breaks down and recycles collagen and hyaluronic acid on a continuous basis. However, excessive sun exposure, injury and nutritional deficiencies can create reduced availability of collagen and hyaluronic acid and result in connective tissue degradation, which manifests as wrinkles, thinning cartilage, brittle hair and other common signs of aging. Some supplements may slow the breakdown of collagen and hyaluronic acid, whereas others may help stimulate their production.
Collagen
Collagen is a protein found mostly in fibrous tissues such as skin, ligaments and tendons, but it’s also abundant in cartilage, bone and blood vessels. All connective tissue, but especially skin, is engaged in a constant cycle of repair and regeneration. The rate of collagen breakdown significantly increases after the age of 40 and is thought to be primarily related to natural aging factors, although nutritional and environmental factors are involved to varying degrees also . Taking measures to boost your collagen production and reduce its breakdown is important for maintaining healthy collagen balance in aging skin.
Hyaluronic Acid
Hyaluronic acid is also found in all connective tissues because it’s needed to bind collagen with elastin. A lack of hyaluronic acid leads to less lubrication in your joints and less elasticity of your skin, which increases the likelihood of cartilage destruction and saggy, wrinkled skin. Your body also produces less hyaluronic acid as you age. The connective tissues of animals are the only natural source of hyaluronic acid, although certain nutrients mildly stimulate your body to produce more of it.
Supplements that Stimulate Production
Since collagen and hyaluronic acid breakdown is a natural process that cannot or should not be completely stopped, stimulating your body to make more of the compounds may be a better strategy. For example, in order for your body to make collagen, it needs vitamin C, lysine and proline. Supplementing with these nutrients allows your body to replenish damaged or old collagen…
Soy products, magnesium-rich foods and seaweeds such as kelp stimulate hyaluronic acid production. Furthermore, collagen and hyaluronic acid supplements can be taken directly.
Collagen cream is applied directly to skin, whereas hyaluronic acid can be taken orally or injected directly into joints…”
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2 comments
slwheeldon@gmail.com says
last month
Hi David,
Wondering if you are willing to share what collagen supplement you use. Or to share what is best to look for in a collagen supplement.
Thank you. Susan
I buy the brand of collagen that is on sale at the whole foods store where I shop. The brand varies sometimes. Not sure what to look for in the collagen unfortunately.
