Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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“Recent studies demonstrate that the GM (gut microbiota) is also a regulator of bone mass (bone health) and it is proposed that the effect of the GM on bone mass is mediated via effects on the immune system, which in turn regulates osteoclastogenesis…”
Whether we are talking about multiple myeloma (MM) itself or many of the MM therapies administered to manage one’s MM, your bone health can get hammered.
Plasma cells (the MM itself) and chemo can damage your bone health and multiple myeloma therapy such as high-dose steroids (dexamethasone, prednisone) actually cause bone-loss.
Therefore, non-toxic multiple myeloma therapy shown to enhance bone health are essential.
The type of cancer patient/survivor that is most at-risk of bone damage is that of an incurable blood cancer called multiple myeloma (MM):
can be an important tool in the MM patient’s toolbox, bisphophonates do have short and long-term side effects. I believe that all myeloma patients must manage toxicity at every point during their journey. Bone health therapies are no different.
While the studies linked and excerpted below are hardly conclusive when it comes to showing that probiotics enance bone health, they do point out specifics of interest to the MMer who is trying to strengthen his/her bone mineral density.
I believe the most important finding of the studies below is the idea that probiotic supplementation can heal bone fractues significantly faster than those not supplementing with probiotics. That is to say that MM patient’s experience all manner of “bone involvement” throughout their lives as MMers. The key is to work to heal one’s bone involvement now and in the future.
I admit to taking the “more is better” approach when it comes to my own probiotic supplementation. I take Garden of Life – RAW Probiotics Men- 85 billion live cultures, 31 different strains. I can offer no research to support my thinking other than the fact that I’ve read a host of studies documenting various strains of probiotics reducing a host of different chronic diseases.
Have you been diagnosed with multiple myeloma? If so, what stage? What symptoms are you experiencing? Scoll down the page, post a question or comment and I will reply to you ASAP.
“The gut microbiota (GM), the commensal bacteria living in our intestine, performs numerous useful functions, including modulating host metabolism and immune status. Recent studies demonstrate that the GM is also a regulator of bone mass and it is proposed that the effect of the GM on bone mass is mediated via effects on the immune system, which in turn regulates osteoclastogenesis. Under normal conditions, the skeleton is constantly remodeled by bone-forming osteoblasts (OBs) and bone-resorbing osteoclasts (OCLs), and imbalances in this process may lead to osteoporosis. Here we review current knowledge on the possible role for the GM in the regulation of bone metabolism and propose that the GM might be a novel therapeutic target for osteoporosis and fracture prevention.”
“Treatment outcomes were the DASH (disabilities of the arm, shoulder and hand) score, pain, complex regional pain syndrome (CRPS) score, active range of motion and grip strength, all of which were measured on a monthly basis. Throughout the duration of the study, DASH score, pain, CRPS score, wrist flexion and grip strength of patients receiving probiotics exhibited a significantly faster pace of improvement than those on placebo, with treatment outcomes of patients receiving Lactobacillus casei Shirota at month 4 at comparable levels with those of patients receiving placebo at month 6. In elderly patients with a fracture of the distal radius, administration of the probiotic could greatly accelerating the healing process.”
“Ninety women were included and 70 completed the study. L. reuteri 6475 reduced loss (enhanced bone health?) of total vBMD compared to placebo both in the intention-to-treat (ITT) analysis... In general, similar but smaller effects were observed in the secondary bone variable outcomes, but these differences did not reach statistical significance in the ITT population…”
“…The Lh-whey increased bone formation 1.3-1.4 times with the 1 x 10(-5), 1 x 10(-4) and 1 x 10(-3) solutions. The IPP and VPP peptides also demonstrated a significant 5-fold activation of bone formation in in vitro osteoblast cultures, whereas the sour milk whey and calcium had no effect. No significant effects were observed on osteoclasts in vitro with any of the study products. L. helveticus fermented milk whey contains bioactive components that increase osteoblastic bone formation in vitro…”