Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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“clinical studies suggest that anthracycline-induced cardio-toxicity can be prevented by administering coenzyme Q10 during cancer chemotherapy that includes drugs such as doxorubicin and daunorubicin.”
I was diagnosed with multiple myeloma in early 1994. During my conventional MM treatments I underwent cardio-toxic chemotherapy regimens including adriamycin (doxorubicin), cytoxan, busulfan and Melphalan. I developed chemotherapy-induced cardiomyopathy (CIC) in late 2010.
I’m writing a CoQ10 health supplement product review for several reasons.
According to ConsumerLabs.com optimal blood levels of CoQ10 may improve heart function through improved ejection fraction, reverse statins side effects, may prevent migraine headaches and pre-eclampsia. CoQ10 supplementation may be useful in treating diseases including muscular dystrophy, AIDS, and hypertension.
Doctor’s Best High Absorption Coq10 w/ BioPerine is approved by ConsumerLab.com for quality and absorption (you must be a member to access the report).
Why do I supplement with Doctor’s Best High Absorption Coq10 w/ BioPerine?
I take Doctor’s Best High Absorption Coq10 w/ BioPerine because it provides the best combination of value, purity, and availability.
Preclinical and clinical studies suggest that anthracycline-induced cardiotoxicity can be prevented by administering coenzyme Q10 during cancer chemotherapy that includes drugs such as doxorubicin and daunorubicin.
Studies further suggest that coenzyme Q10 does not interfere with the antineoplastic action of anthracyclines and might even enhance their anticancer effects. Preventing cardiotoxicity might allow for escalation of the anthracycline dose, which would further enhance the anticancer effects. Based on clinical investigation, although limited, a cumulative dose of doxorubicin of up to 900 mg/m2, and possibly higher, can be administered safely during chemotherapy as long as coenzyme Q10 is administered concurrently. The etiology of the dose-limiting cardiomyopathy that is induced by anthracyclines can be explained by irreversible damage to heart cell mitochondria, which differ from mitochondria of other cells in that they possess a unique enzyme on the inner mitochondrial membrane. This enzyme reduces anthracyclines to their semiquinones, resulting in severe oxidative stress, disruption of mitochondrial energetics, and irreversible damage to mitochondrial DNA. Damage to mitochondrial DNA blocks the regenerative capability of the organelle and ultimately leads to apoptosis or necrosis of myocytes. Coenzyme Q10, an essential component of the electron transport system and a potent intracellular antioxidant, appears to prevent damage to the mitochondria of the heart, thus preventing the development of anthracycline-induced cardiomyopathy.
“Results-Six studies were included in the review, including three randomized clinical trials and three nonrandomized clinical trials. Patients in five of six studies received anthracyclines. The results suggested that CoQ10 provides some protection against cardiotoxicity or liver toxicity during cancer treatment. However, because of inadequate reporting and analysis, as well as questionable validity of outcome measures, the results are not conclusive.