Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Hi Cancer Coach- Have you ever heard of this glutathione (GSH)? I think this article is saying it is bad for MM patients. When I was discussing IV Therapy at a local clinic they mentioned glutathione for cleaning the liver, but I wanted to ask you about glutathione and its affect on multiple myeloma chemotherapy such as velcade.
Let me know, thanks. Kathy
My take on the article linked below is that glutathione enhanced the sensitivity of MM cells to bortezomib- “Inhibiting Xc- activity potentiated bortezomib-induced cytotoxicity in myeloma cell lines and primary cells, and re-established sensitivity to bortezomib in bortezomib-conditioned cells. And that GSH “dampened” the cytotoxicity of Velcade.
Also, glutathione is a health promoting antioxidant. GSH is one of a long and growing list of therapies that integrate with conventional multiple myeloma chemotherapy. The studies below say that glutathione helps the MMer taking Revlimid (bortezomib) in several ways:
To learn more about evidence-based, non-conventional, non-toxic therapies, managing and alleviating side effects, and overall structuring your life to support your body and fight Multiple Myeloma, please watch the video below:
“Multiple myeloma (myeloma in short) is an incurable cancer of antibody-producing plasma cells that comprise 13% of all hematological malignancies. The proteasome inhibitor bortezomib has improved treatment significantly, but inherent and acquired resistance to the drug remains a problem.
We here show that bortezomib-induced cytotoxicity was completely dampened when cells were supplemented with cysteine or its derivative, glutathione (GSH) in ANBL-6 and INA-6 myeloma cell lines. GSH is a major component of the antioxidative defense in eukaryotic cells.
Increasing intracellular GSH levels fully abolished bortezomib-induced cytotoxicity and transcriptional changes. Elevated intracellular GSH levels blocked bortezomib-induced nuclear factor erythroid 2-related factor 2 (NFE2L2, NRF2)-associated stress responses, including upregulation of the xCT subunit of the Xc- cystine-glutamate antiporter.
INA-6 cells conditioned to increasing bortezomib doses displayed reduced bortezomib sensitivity and elevated xCT levels. Inhibiting Xc- activity potentiated bortezomib-induced cytotoxicity in myeloma cell lines and primary cells, and re-established sensitivity to bortezomib in bortezomib-conditioned cells. We propose that intracellular GSH level is the main determinant of bortezomib-induced cytotoxicity in a subset of myeloma cells, and that combined targeting of the proteasome and the Xc- cystine-glutamate antiporter can circumvent bortezomib resistance.”
“An essential antioxidant, glutathione is involved in:
and many other important processes. Higher glutathione levels have been linked to better health and longevity, while lower levels are associated with conditions such as cancer, heart disease, diabetes, dementia, and Parkinson’s disease. Levels also decline with age.
But how much we need—and whether supplementation helps—is largely unknown. Like other proteins, when glutathione is consumed orally, it is broken down into its amino acids in the gastrointestinal tract. So it’s not surprising that studies using oral doses as a way to boost glutathione levels and produce antioxidant effects in the body have been disappointing overall. Other forms—intravenous, inhaled, or intramuscular—are more likely to survive intact for cells to use.
“GSH is one of the body’s most important and potent antioxidants. Antioxidants are substances that reduce oxidative stress by combating free radicals in the body.
While most antioxidants are found in the foods you eat, GSH is produced by your body. It is primarily made up of three amino acids: glutamine, glycine and cysteine (1).
There are a number of reasons why your body’s GSH level may become depleted, including poor diet, chronic disease, infection and constant stress.
Glutathione is also known to decrease with age (1).
Maintaining adequate levels of this antioxidant is incredibly important. Below are 10 of the best ways to increase your GSH levels naturally…”