Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Thank you for sharing your incredible wealth of knowledge. I am 1 year out of an autologous stem cell transplant for Multiple Myeloma and would like to know the brand and dosage of curcumin, resveratrol, green tea extract and omega 3 fatty acids you advise and anything else important for MM to help me maintain as long a remission as I can.
The bone healing has been the most difficult part with fractures in the spine. Otherwise, I am active, biking, walking and working. Have not and will not do radiation.
All the Best, Jill
I am sorry to read of your MM but I am encouraged by your desire to make an effort to remain in remission. To answer your question “would like to know the dosage of Curcumin, resveratrol, green tea extract and omega’s you advise…” Several things.
First off, I have been in complete remission from MM since ’99 and supplementing with those you mention for years now. I take a maintenance dose of each. By this, I mean that I take even less than the doses recommended on the labels of each. I take a brand called Life Extension Foundation of each of the supplements you asked about. Further, I have linked a guide about anti-MM supplements below.
I have read both studies and personal accounts of MMers taking up to 8 grams of curcumin (1000 mg is 1 gram). I know of one MMer who is taking 2 grams of resveratrol. Further, omega 3 fatty acids can thin one’s blood. Those MMers also taking prescription blood thinners such as coumadin must work with their oncologist to supplement with omega 3 fatty acids.
Lastly, while the evidence is spotty, there is reason to believe that certain supplements work synergistically with each other. Therefore it is difficult for me to advise doses for you. I would recommend you seeing a naturopath to work with who might be able to counsel you on this issue.
As for additional lifestyle MM therapies I recommend frequent but moderate exercise. My leg function is limited so I spend 30 min. on an elliptical 3 days a week and do light lifting the other three days a week. When I say light I mean light. The weight bearing aspect of this activity should help you manage your bone health, healing, etc. But since you are active as you say you probably know more about this than I do.
I am conflicted about my own local radiation. Yes, local radiation did cause long-term side effects (radiation-induced lumbosacral plexopathy). But local radiation also bought me about a year during with I pursued other MM therapies. I hope you never have to decide…
My diet is based on this TED Talk by Dr. Bill Li–
Let me know if you have any other questions and good luck Joan.
“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”
A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
I consult the independent evaluation service Consumerlab.com frequently. For one low annual payment, I can read about and evaluate all of the nutritional supplement that I take.
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.“
“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.
The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.
Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.
Based on the published reports,
exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”
According to Consumerlab.com:
“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”