Myeloma- Transplant, Heart Failure- PeopleBeatingCancer

Myeloma- Transplant, Heart Failure-

“These (CVD) complications can occur both acutely within the first 100 days as well as long-term, many years after the initial transplantation (HSCT) period…”

I don’t know what’s more frightening, the fact that multiple myeloma (MM) patients who have had a hematopoietic stem cell transplant (HSCT) have an increased risk of cardiovascular disease or that you may already have cardiovascular disease and not know it.

I wish I knew that a multiple myeloma side effect was heart failure.

According to the study linked and excerpted below “Prior studies report that 9–27 % of persons receiving HSCT develop arrhythmias,[2•]…”

I am a long-term survivor of the blood cancer called multiple myeloma. I underwent an autologous stem cell transplant in 12/95. My oncologist said nothing about heart damage being MM side effect.

I developed chronic atrial fibrillation (a-fib) in the fall of 2010. This is what’s called a “late stage” side effect. It happened 15 years after my ASCT.

Yes, it is ventricular systolic dysfunction (LVSD). At that cardiology appointment the M.D. didn’t really confirm a diagnosis of chemotherapy-induced cardiomyopathy. That diagnosis was confirmed by a different cardio-oncologist at another appointment on 1/2/19.

The good news is that this side effect can be managed. Studies support CoQ10 supplementation, omega 3 fatty acid supplementation, resveratrol supplementation, and curcumin supplementation. Well, to be fair, I should have begun all those therapies years ago.

I live with chemotherapy-induced cardiomyopathy (CICM) and am working to rehabilitate my heart daily through:

moderate exercise,
whole-body hyperthermia (sauna)
nutrition,
supplementation,
and other heart healthy lifestyle therapies.

I supplement with and recommend Life Extension Super Ubiquinol Coq10 with Biopqq Softgels to manage my chemo-induced heart damage.

For questions about other supplements and lifestyle therapies that can help manage your chemotherapy-induced heart failure, scroll down the page, post a question or comment and I will reply ASAP.

thank you,

David Emerson

Multiple Myeloma Survivor
MM Coach
Director PeopleBeatingCancer

Cardiovascular Complications of Hematopoietic Stem Cell Transplantation

“Survivors of hematopoietic stem cell transplant (HSCT) are at significant risk for cardiac disease and cardiac complications. While there may be cardiac complications during the acute period of HSCT, long-term survivors remain at risk for cardiovascular disease at a rate at least fourfold higher than the general population…

Cardiovascular disease and cardiovascular complications are one of the most common complications associated with HSCT. These complications can occur both acutely within the first 100 days as well as long-term, many years after the initial transplantation period. Prior studies report that 9–27 % of persons receiving HSCT develop arrhythmias,[2•]…

Other cardiac complications of HSCT include:

congestive heart failure (CHF),
cardiac tamponade, and
ventricular arrhythmias resulting in death.[3]

While cardiac tamponade and ventricular arrhythmias are rare occurring in <1 % of recipients, CHF remains a concern particularly as the age of individuals undergoing HSCT increases. Most preparative regimens for allogeneic HSCT use cyclophosphamide (CY). High-dose CY can induce myocardial necrosis which clinically presents with dyspnea, tachycardia, hypotension, decreased QRS voltage on electrocardiogram, and pericardial effusion within ten days of drug administration.[7–10]…

The risk of cardiovascular anthracycline-induced cardiomyopathy complications in autologous HSCT survivors, however, also remains of concern in which the cumulative incidence of CHF at 5 years after HSCT of 4.8 %, increasing to 9.1 % at 15 years.[34]

Overall, this cardiovascular risk is 4.5-fold higher than that seen in the general population. Prior anthracycline use and chest radiation also increases this risk..”

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4 comments

How Painful is Multiple Myeloma? - PeopleBeatingCancer says 4 years ago

[…] Multiple Myeloma Side Effects- Stem Cell Transplant & Heart Failure- […]

Clinical Trials for Low-dose Lenalidomide (Revlimid) are Inaccurate - PeopleBeatingCancer says 5 years ago

[…] Multiple Myeloma, Hematopoietic Stem Cell Transplant and Heart Failure- […]

Kristal Timm says 9 years ago

My daughter, age 14, has been diagnosed with nodular sclerosis Hodgkin Lymphoma– stage 2 with bulky disease. I am looking for information on alternative treatments or help to protect her from the long-term effects if we must put her through chemotherapy.

David Emerson says 9 years ago

Hi Kristal-

I am sorry to learn of your daughter’s cancer diagnosis. I am happy that you are thinking through possible long-term and late stage side effects if she undergoes chemo or radiation.

Keep in mind that we are talking about “integrative” therapies rather than alternative. I am pointing out the difference only to stress that you and your daughter are working to both enhance the efficacy of chemo and radiation in addition to reducing the toxicity.

Our discussion will work more smoothly if you learn of the chemotherapies you daughter may undergo so that I can research and email you studies and therapies accordingly.

As an example I might report that a class of chemotherapies called “anthracyclines” are a common therapy for blood cancers. I underwent doxorubicin as one of my induction chemo drugs in ’94. I developed chronic atrial fibrillation in 2010. Supplementing with CoQ10 has been shown to prevent the cardiomyopathy of this class of chemo.

Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity.

In general, antioxidant supplements such as curcumin and resveritrol have been shown to enhance certain chemotherapies while reducing toxicity. But I can be more specific if you can tell me what the autologous stem cell transplant regimen will be that your daughter may undergo. As an aside, this is a fair question for you to ask and your oncologist should know this information.

Anthracycline

“Daunorubicin (Daunomycin)
Daunorubicin (liposomal)
Doxorubicin (Adriamycin)
Doxorubicin (liposomal)
Epirubicin
Idarubicin
Valrubicin, used only to treat bladder cancer
Mitoxantrone, anthracycline analog”

Please let me know if this makes sense to you and if you have any questions.

Hang in there-

David Emerson

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Myeloma- Transplant, Heart Failure-

“These (CVD) complications can occur both acutely within the first 100 days as well as long-term, many years after the initial transplantation (HSCT) period…”

Recommended Reading:

Cardiovascular Complications of Hematopoietic Stem Cell Transplantation

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