What I wish I knew about Multiple Myeloma treatments 25 years later...

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Multiple Myeloma- Tally DVT/VTE Risk Before Revlimid, Thal, Pom, Imnovid

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“VTE/DVT is an under-recognized but frequently encountered complication … common in patients with multiple myeloma receiving IMiDs, and can cause disability, delay or complicate chemotherapy, and — in rare cases — be fatal…”

Two weeks after I began induction therapy for multiple myeloma (MM), I developed a deep vein thrombosis (DVT). According to the study linked below, my SAVED score would have been 3 and therefore would have indicated that my risk of blood clot was high.

Newly diagnosed MM patients should understand that managing side effects from chemotherapy can increase their quality of life and quantity of life. Blood clots, both DVT and VTE, are a great example of a common side effect that is relatively easy to prevent.

Though the standard-of-care therapy to reduce the risk of blood clots are blood thinning medications such as Plavix, Eliquis and Xarelto, there are many evidence-based supplements and lifestyle therapies that can also reduce the risk of blood clots.

To lower my risk of blood clots I take:

In addition to frequent, moderate exercise and nutrition to also reduce my risk of blood clots.

Have you been diagnosed with multiple myeloma? Are you about to begin induction therapy and are wondering about your risk of DVT? Scroll down the page, post a question or comment and I will reply to ou ASAP.

Thank you,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

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Tally of Risk Factors Can Identify Myeloma Patients at Risk of Deep-vein Blood Clots, Study Suggests

“A simple score of risk factors could help alert doctors to a likelihood of dangerous blood clots, called venous thromboembolism, forming as a side effect of immunomodulatory therapies (IMiD) for multiple myeloma.

Researchers established the set of factors — based on a person’s

  • age,
  • race,
  • and medical history —

and how to score them so to better identify patients at risk for these clots, which could be prevented with anticoagulant (blood thinner) use…

Patients are especially at risk when using immunomodulatory treatment regimens such as Revlimid (lenalidomide), Thalomid (thalidomide), and Pomalyst(pomalidomide; sold as Imnovid in Europe)…

“VTE is an under-recognized but frequently encountered complication … common in patients with multiple myeloma receiving IMiDs, and can cause disability, delay or complicate chemotherapy, and — in rare cases — be fatal…”

Researchers identified five clinical variables associated with a greater VTE risk:

  • a prior history of VTE,
  • surgery within 90 days,
  • age 80 or older,
  • high dexamethasone  dose (greater than 160 mg), and
  • non-Asian race…

The model identified approximately 30% patients at high risk. Depending on the dataset, these patients were 85% to 98% more likely (nearly twice as likely) compared to low-risk patients of having a VTE..”

Derivation and Validation of a Risk Assessment Model for Immunomodulatory Drug–Associated Thrombosis Among Patients With Multiple Myeloma

Background: Although venous thromboembolism (VTE) is a significant complication for patients with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs), no validated clinical model predicts VTE in this population…

Conclusions: The SAVED score outperformed the current NCCN Guidelines in risk-stratification of patients with MM receiving IMiD therapy. This clinical model can help inform providers and patients of VTE risk before IMiD initiation and provides a simplified clinical backbone for further prognostic biomarker development in this population…”

 

 

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