Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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I’ve been supplementing with curcumin since ’06 because it is a well-documented multiple myeloma therapy. I know of no more effective or more complete evidence-based, non-conventional therapy for multiple myeloma patients and survivors.
Further, several years after my ASCT, I confirmed my chemotherapy-induced, cerebral dysfunction aka chemobrain.
And then in late 2010, I developed chronic atrial fibrillation (Afib) which led to a diagnosis of chemotherapy-induced cardiomyopathy (CIC).
Over the years since first supplementing with curcumin for my cancer I have learned about curcumin’s effects on many other cancers as well as curcumin’s ability to synergize with conventional chemotherapy.
With its documented anti-MM, pro-brain health, pro-heart health, I think curcumin is a wonder drug.
It it important for all those using curcumin to understand that some brands are better and more efficacious than others. I rely on consumerlab.com to evaluate the different brands of curcumin.
I am a long-term multiple myeloma survivor and MM coach. Experience and research has taught me that conventional oncology is only part of the picture when managing a multiple myeloma diagnosis.
Do you have MM? What stage? Please scroll down the page, post a question or comment and I will reply to you ASAP.
“Turmeric and its key compound, curcumin, may be helpful in treating inflammation and conditions such as depression, diabetes, and indigestion. However, supplements on the market vary widely in the amounts of key curcumin compounds they contain, and some formulations may be better absorbed than others.”
“Overall, our review shows that curcumin can kill a wide variety of tumor cell types through diverse mechanisms. Because of numerous mechanisms of cell death employed by curcumin, it is possible that cells may not develop resistance to curcumin-induced cell death. Furthermore, its ability to kill tumor cells and not normal cells makes curcumin an attractive candidate for drug development…”
“”Curcumin has multiple physiological effects,” said lead researcher of the 2015 paper, Andrew Scholey, from Swinburne University of Technology. “It’s known to reduce inflammation and improve blood flow. It influences multiple processes that nudge brain function in a positive direction.””
” It has been used in a variety of diseases in traditional medicine. Modern scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular protective effects…
The inflammatory effects of curcumin may have the possibility of preventing atrial arrhythmias and the possible effect of curcumin for correcting the Ca(2+) homeostasis may play a role in the prevention of some ventricular arrhythmias…”
“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”
A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
I consult the independent evaluation service Consumerlab.com frequently. For one low annual payment, I can read about and evaluate all of the nutritional supplement that I take.
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.“
“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.
The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.
Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.
Based on the published reports,
exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”
According to Consumerlab.com:
“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”