Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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When I first read about curcumin, I learned about an evidence-based multiple myeloma therapy that was also non-toxic. I was ecstatic. Numerous studies, in vitro, in vivo, in humans, have shown that curcumin, a non-toxic therapy, not only kills MM but also synergizes to enhance the MM killing ability of both velcade and revlimid.
Skip ahead 10-15 years…I’ve come to realize that MM patients and survivors face challenges throughout their lives living with MM. It’s not just about multiple myeloma cytotoxicity…
The over-arching challenge multiple myeloma patients and survivors face is that multiple myeloma therapy, FDA approved, standard-of-care chemotherapy that is, too often cause the same health problems that their incurable blood cancer does. MM side effects are often indistinguishable from MM symptoms.
Newly diagnosed multiple myeloma patients believe that their oncologists are prescribing multiple myeloma therapies that will give them years of survival. At least I did when I was diagnosed with MM in early 1994.
To complicate the life of the average MM patient, conventional MM oncology focuses on the cure in the cure vs. control debate. While we all want to cure our incurable blood cancer, the fact is that this is short-term thinking.
By prescribing the newly diagnosed MM patient so much toxicity in the beginning of his/her life as a MM patient, oncology is condemning that patient to a life of short, long-term and late stage side effects followed by multi-drug resistance (MDR) and death.
For example, if the MM patient experiences bone damage when h/she is diagnosed, the induction therapy prescribed may include dexamethasone, a steroid shown to weaken bones.
If the MM patient is suffering from kidney damage upon diagnosis, h/she may be prescribed revlimid aka lenalidomide, a chemotherapy known to cause kidney damage.
Chemotherapy in general and particularly the high-dose, aggressive chemotherapy that comes with an autologous stem cell transplant can damage bone marrow temporarily and possibly permanently.
There are two solutions to the general problem of toxic chemotherapy regimens that cause as much damage as not:
Have you been diagnosed with multiple myeloma? To learn more about both conventional and evidence-based non-conventional MM therapies scroll down the page, post a question or comment and I will reply to you ASAP.
“However, chemotherapy only has a limited success with severe side effects, especially causing damage to normal tissues such as bone marrow, gastrointestine, heart, liver, renal, neuron, and auditory tissues, etc. The side-effects limit clinical outcome of chemotherapy and lower patients’ quality of life, and even make many patients discontinue the chemotherapy. Thus, there is a need to explore effective adjuvant strategies to prevent and reduce the chemotherapy-induced side effects…
In the present article, we review the preventive effect of curcumin against:
and discuss its action mechanisms…”
“The present study demonstrated that curcumin was able to induce cell death of HMCLs belonging to the main MM subtypes. Taking into account myeloma molecular heterogeneity, we found that most sensitive HMCLs were spread out over the t(14;16) and t(4;14) subgroups…
All these findings might support clinical trials including curcumin in association with standard therapy, as chemoresistance remains a major challenge in myeloma treatment…”
“Chronic kidney disease (CKD), an inflammatory disease, can lead to end stage renal disease resulting in dialysis and transplant. Furthermore, it is frequently associated with other inflammatory disease such as diabetes and cardiovascular disorders…”
“Osteopenia is a chronic bone condition characterized by decreased calcification, density, or bone mass that, if untreated, can lead to osteoporosis and bone fractures…In this study, we evaluated the efficacy, in term of changes in bone density, and safety of an oral formulation based on turmeric phytosome (Meriva®), in subjects suffering from low bone density…
Results: The bone density of the heel measured by the Sahara densitometer remarkably improved in the Meriva®-supplemented group, with a significant decrease of ultrasounds transmission values at week 12 (-18.4%) and at week 24 (-21.0%), compared with baseline values… Last, no safety and tolerability issues were reported during the observational period.
Conclusions: This preliminary study suggests that a curcumin-based supplementation in combination with an appropriate lifestyle could be beneficial in the prevention and management of osteopenia…”
In this review, we focused mainly on the effects of curcumin on the cardiovascular system. The antioxidant effects of curcumin have been shown to attenuate adriamycin-induced cardiotoxicity and may prevent diabetic cardiovascular complications.
The anti-thrombotic, anti-proliferative, and anti-inflammatory effects of curcumin and the effect of curcumin in decreasing the serum cholesterol level may protect against the pathological changes occurring with atherosclerosis…”