Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Hi David- I am a 60 year old Multiple Myeloma patient. After my diagnosis and induction multiple myeloma treatment I experienced three years of remission. I have now relapse happened. So I am back on Dexamethasone, Darzalex, Revlimid & now my calcium hiked to 11 points. This result is a bit in the above the “normal” range, so next week onwards, Kyprlis is added.
I am doing ok, don’t have severe side effects other than moderate numbness on the feet. My sleep is broken. General weakness is there and moderate pain on the back and both side of the rib cage.
I live with wife (NP-hospice) and son in Dallas, Texas.
Today I took two drops hemp CBD oil water-soluble (500mg, with no THC) and found a bit relaxed in my pain.
So I am wondering, what dosage I shall take regularly, and is it going to affect my treatment? I have no known heart, kidney or liver issues. I go for walks, but my activities are limited due to tiredness and back pain.
Please advise what else I can do to improve my life and live with this better. I am an artist by profession, but I cannot paint for a long time now. This makes me depressed at times. I do not drink or smoke and I don’t eat meat, but fish and veg a lot.
I am pretty impressed by the excellent service you are doing, and the hope that permeates from your words.
Thanks in advance, Sebastian
“Cannabidiol (CBD) is a type of cannabinoid, a chemical found naturally in cannabis (marijuanaand hemp) plants. CBD doesn’t cause the “high” feeling often associated with cannabis. That feeling is caused by tetrahydrocannabinol (THC), a different type of cannabinoid.
“Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM). Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor.
TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells…
Because bortezomib (BORT) is commonly used in MM treatment, we investigated the effects of CBD and BORT in CD138+TRPV2- MM cells and in MM cell lines transfected with TRPV2 (CD138+TRPV2+).
These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells.
These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM…”
“Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways involved in cancer cell proliferation, chemo-resistance and migration.
Cannabidiol (CBD) was previously noted in multiple myeloma (MM), both alone and in synergy with the proteasome inhibitor bortezomib, to induce cell death.
In other type of human cancers, the combination of CBD with Δ9-tetrahydrocannabinol (THC) was found to act synergistically with other chemotherapeutic drugs suggesting their use in combination therapy.
In the current study, we evaluated the effects of THC alone and in combination with CBD in MM cell lines. We found that CBD and THC, mainly in combination, were able to reduce cell viability by inducing autophagic-dependent necrosis.
Furthermore, since the immuno-proteasome is considered a new target in MM and also since carfilzomib (CFZ) is a new promising immuno-proteasome inhibitor that creates irreversible adducts with the β5i subunit of immuno-proteasome, we evaluated the effect of CBD and THC in regulating the expression of the β5i subunit and their effect in combination with CFZ.
Herein, we also found that the CBD and THC combination is able to reduce expression of the β5i subunit as well as to act in synergy with CFZ to increase MM cell death and inhibits cell migration.
In summary, these results proved that this combination exerts strong anti-myeloma activities…”