“Curcumin exerts a cytotoxic effect additive to that of lenalidomide on H929 myeloma cells, and it also enhances the chemo-sensitizing effects of this agent.”
Hi David- I was diagnosed with multiple myeloma 5 yrs ago. I am currently on Revlimid which I am not coping very well with. I would love to think I could go into remission. I am 80 yrs old and have no energy and the Dr has said that I need to stay on the meds or else he gives me 2 months.
I have had to have several blood transfusions. With this COVID-19 I am not really wanting to go into to hospital for more of the same transfusions.
I am taking CBD and lots of different vitamins. I follow a Vegan diet. Green juice in the morning for breakfast and the rest of my diet is healthy as my wife makes sure of that.
Look forward to hearing from you.
I think evidence-based but non-toxic, non-conventional MM therapies relate more to the 80 year old MM patient than they do to the 50 year old MM patient. I’ll tell you why I think this.
I do not mean to disagree with or contradict your oncologist in any way. He/she can understand your health history in more detail than I can.
Having said that, I believe that the goal of the 80 year old patient should be tilted more toward quality of life and away from length of life. That means that, for example, you may take a lower dose of Revlimid and combine this lower dose with evidence-based integrative therapy. Please see the article linked below that cites curcumin’s ability to enhance the efficacy of Revlimid.
I believe that MM survivors can live well with low m-spikes, and other diagnostics. In other words, it is common for oncologists (American ones anyway) to always go for complete remission aka an m-spike of 0. My experience is that many MM, perhaps the majority of MM survivors, live with small numbers of MM cells IN their blood. Like living with prostate cancer in your prostate gland…
Lastly, your other lifestyle therapies (nutrition, juicing) are also excellent therapies.
- As an aside, I disagree vehemently with oncology making a statement like “without chemo, I give you two months…”
- Your lack of energy as well as your need for blood transfusions may well be a result of too much chemotherapy. Yes, MM can cause anemia but so can Revlimid…
- Re COVID-19, consider intravenous vitamin C. High dose I.V. vitamin C has been shown to kill MM as well as kill COVID. See study linked below.
Let me know if you have any other questions. Good luck, be well.
- MM Survivor
- MM Coach
- Director PeopleBeatingCancer
Revlimid is the same as lenalidomide-
“Background: Curcumin, the active component of the Curcuma longa plant, has been shown to potentiate the effect of the immunomodulatory drugs (IMiDs) thalidomide and Bortezomib against human myeloma cell lines and a nude mice model.
Its effect on the other IMid, lenalidomide, has not been evaluated. This study aims to investigate the mechanism of action of curcumin and its potential ability to positively interact with lenalidomide.
Method: we designed an in-vitro study to investigate the cytotoxic and chemo-sensitising effects of curcumin alone and in combination with lenalidomide on the human myeloma H929 cell line. Results: Incubation of H929 cells with curcumin (30M) or lenalidomide (2.5 mM) for 3 days resulted in 26.35% (±1.06) and 30.81%(±2.98) apoptotic cells respectively.
When 30 M curcumin was combined with 2.5 mM lenalidomide, 50.4% (±3.37) apoptotic cells were detected by flow cytometry and the increase was significant compared to either curcumin alone or lenalidomide alone (anova p = 0.0026).
Furthermore, gene analysis studies show that curcumin enhances the cytotoxic effect of lenalidomide via suppression of the cereblon and multi-drug resistant genes.
Conclusion: Curcumin exerts a cytotoxic effect additive to that of lenalidomide on H929 myeloma cells, and it also enhances the chemo-sensitizing effects of this agent.”
“High-dose chemotherapies to treat multiple myeloma (MM) can be life-threatening due to toxicities to normal cells and there is a need to target only tumor cells and/or lower standard drug dosage without losing efficacy. We show that pharmacologically-dosed ascorbic acid (PAA), in the presence of iron, leads to the formation of highly reactive oxygen species (ROS) resulting in cell death. PAA selectively kills CD138+MM tumor cells derived from MM and smoldering MM (SMM) but not from monoclonal gammopathy undetermined significance (MGUS) patients. PAA alone or in combination with melphalan inhibits tumor formation in MM xenograft mice. This study shows PAA efficacy on primary cancer cells and cell lines in vitro and in vivo…”