Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

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Myeloma and Fenbendazole?

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Myeloma and Fenbendazole? I am a long-term survivor of an incurable blood cancer called multiple myeloma. Since my oncologist told me that I was end-stage and “we can do nothing more for you,” I have searched high and low for evidence-based MM therapies that can help me manage my cancer.

There has been so much anecdotal talk about Fenben, I have been researching the Internet for info on this repurposed drug. To be fair, I have to go on record as looking for legit research on the effect that fenben has on MM.  I don’t pay much attention to anecdotes.

The bottom line, for me anyway, is that there is no evidence that Fenben treats MM in humans. Fenben may be helpful, it may not. There is no way of knowing. And there are potential side effects that worry me.

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Peer-reviewed myeloma studies that include fenbendazole

  1. Targeting the microtubular network as a new antimyeloma strategy (2011) – Molecular Cancer Therapeutics

  • What it is: In-vitro (MM cell lines; also includes stromal co-culture work) and in-vivo xenograft work focused on benzimidazoles/microtubule disruption; the paper includes fenbendazole among the benzimidazoles tested in MM cell experiments.

  • PubMed: https://pubmed.ncbi.nlm.nih.gov/21825007/

  1. Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents (2010) – Leukemia Research

  • What it is: A screening study in MM context (drug discovery / repurposing-style screen). This is part of the same research line that later published the 2011 Mol Cancer Ther paper above; it’s one of the key “upstream” studies leading into the benzimidazole findings.

  • PubMed: https://pubmed.ncbi.nlm.nih.gov/20116850/

Conference abstract (still a “study,” but not a full peer-reviewed paper)

  1. Nocodazole Induces Myeloma Cell Death… (ASH meeting abstract; 2008) – Blood (abstract)

What I did not find (important)

  • No human clinical trials of fenbendazole specifically in multiple myeloma in the indexed biomedical literature surfaced in these searches. (There are benzimidazole relatives like mebendazole and flubendazole with myeloma preclinical data, but that’s not fenbendazole.)

If you want, I can also provide a separate section listing the closest “adjacent” evidence(mebendazole/flubendazole/albendazole in MM) with PubMed links—useful for context, but distinct from “fenbendazole + myeloma” specifically.

Closest “adjacent” evidence (other benzimidazoles studied in multiple myeloma)

These are not fenbendazole, but they’re chemically related antiparasitic benzimidazoles with direct preclinical multiple myeloma data (cell lines/primary samples ± mouse models).

Mebendazole (MBZ) + multiple myeloma

  • “Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis” (2019) – Acta Pharmacologica Sinica

  • Models: MM cell lines + mechanistic work; in vivo xenograft reported in the study summary.
  • Main finding: MBZ showed antimyeloma activity linked to inhibiting the USP5/c-Maf pathway.
  • PubMed: https://pubmed.ncbi.nlm.nih.gov/31197245/

Flubendazole + multiple myeloma

  • “The antihelmintic flubendazole inhibits microtubule function and displays preclinical activity in leukemia and myeloma” (2010) – Blood

  • Models: Myeloma cell lines + primary patient samples; also xenograft activity reported.
  • Main finding: Flubendazole acts as a microtubule inhibitor with preclinical anti-myeloma effects.
  • PubMed: https://pubmed.ncbi.nlm.nih.gov/20348394/

Albendazole (ABZ) + multiple myeloma

  • “Albendazole inhibits NF-κB signaling pathway to overcome tumor stemness and bortezomib resistance in multiple myeloma” (2021) – Cancer Letters

    • Models: In vitro + in vivo (per abstract); includes bortezomib-resistance and “stemness” angle.
    • Main finding: ABZ suppressed MM growth and was linked to NF-κB pathway inhibition, with reported effects on resistance/stem-like populations.
    • PubMed: https://pubmed.ncbi.nlm.nih.gov/34390764/

Myeloma and Fenbendazole Myeloma and Fenbendazole Myeloma and Fenbendazole

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