Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Anti-aging… myth or reality? I have to begin this post by saying that I launched the Galen Foundation in 2004 in my effort to manage my multiple myeloma (MM) and growing list of long-term and late stage side effects. An incurable blood cancer (MM) is difficult enough as it is. But therapy-related secondary cancers, chemotherapy-induced cardiomyopathy, chemobrain, CIPN, etc. Yikes…
But when a MM CC friend posted the top study linked below on our private, closed, online group- Beating Myeloma, I was taken aback at first. I say this because my approach to my cancer and side effects has always been…evidence-based. And anti-aging, in my mind anyway, seemed sort of… I don’t know… vain. Not very evidence-based.
But once I thought about it, the MM CC program of nutrition, supplementation (many of which are anti-inflammatory), and lifestyle, are:
In effect, those practices that might change how a person’s genes express themselves and, at least, slow the aging process. In short, the Multiple Myeloma Cancer Coaching Program is both anti-MM and anti-aging.
In terms of measuring my anti-aging efforts over the past 20 years or so, my one tangible indicator of something discussed in the article is healthcare costs. Once I achieved complete remission from multiple myeloma, I stopped spending money on chemo, imaging tests, diagnostic tests, etc. I have no “healthcare costs.” I spend money on food, a health club, nutritional supplements, things like that, but not healthcare expenses in the usual sense.
I will work to develop additional methods to measure any/all anti-aging, symptoms of epigenetic aging, anything to determine if my diet, lifestyle, etc. are slowing my biological aging.
If you have any questions or comments please scroll down the page, post and I will reply to you ASAP.
“Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72.
The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients…
The diet and lifestyle treatment was associated with a 3.23 years decrease in DNAmAge compared with controls (p=0.018). DNAmAge of those in the treatment group decreased by an average 1.96 years by the end of the program compared to the same individuals at the beginning with a strong trend towards significance (p=0.066).
Changes in blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) and mean triglycerides (-25%, p=0.009).
To our knowledge, this is the first randomized controlled study to suggest that specific diet and lifestyle interventions may reverse Horvath DNAmAge (2013) epigenetic aging in healthy adult males…”
“Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward this end, we use recent epigenetic biomarkers of age that have previously been shown to predict all-cause mortality, chronic conditions, and age-related functional decline.
We analyze cross-sectional data from 4,173 postmenopausal female participants from the Women’s Health Initiative, as well as 402 male and female participants from the Italian cohort study,
Invecchiare nel Chianti.Extrinsic epigenetic age acceleration (EEAA) exhibits significant associations with
whereas intrinsic epigenetic age acceleration (IEAA) is associated with poultry intake (p=0.03) and BMI (p=0.05). Both EEAA and IEAA were also found to relate to indicators of metabolic syndrome, which appear to mediate their associations with BMI. Metformin-the first-line medication for the treatment of type 2 diabetes-does not delay epigenetic aging in this observational study.
Finally, longitudinal data suggests that an increase in BMI is associated with increase in both EEAA and IEAA.
Overall, the epigenetic age analysis of blood confirms the conventional wisdom regarding the benefits of eating a high plant diet with lean meats, moderate alcohol consumption, physical activity, and education, as well as the health risks of obesity and metabolic syndrome.”
“Interactions between genetic (genome) and environmental factors (epigenome) operate during a person’s entire lifespan. The aging process is associated with several cellular and organic functional alterations that, at the end, cause multi-organic cell failure.
Epigenetic mechanisms of aging are modifiable by appropriate preventive actions mediated by
The Mediterranean lifestyle has been for many millennia a daily habit for people in Western civilizations living around the Mediterranean sea who worked intensively and survived with very few seasonal foods.
A high adherence to the traditional Mediterranean diet is associated with low mortality (higher longevity) and reduced risk of developing chronic diseases,
Reports indicate that some dietary components, such as olive oil, antioxidants, omega-3 and -6 polyunsaturated acids, polyphenols and flavonoids, mediate beneficial anti-aging effects (anti-chronic diseases and increased longevity). Equally, physical activity displays a positive effect, producing caloric consumption and regulation of adipose and pancreatic function. The predictive strength of some food patterns may be a way of developing recommendations for food and health policies. This paper will discuss several ways of improving health during mid-life, focusing on certain groups of functional foods and healthy habits which may reduce or prevent age-related chronic diseases.”
“Longevity is a very complex phenomenon, because many environmental, behavioral, socio-demographic and dietary factors influence the physiological pathways of aging and life-expectancy. Nutrition has been recognized to have an important impact on overall mortality and morbidity; and its role in extending life expectancy has been the object of extensive scientific research.
This paper reviews the pathophysiological mechanisms that potentially link aging with diet and the scientific evidence supporting the anti-aging effect of the traditional Mediterranean diet, as well as of some specific foods.
The diet and several of its components have additionally been shown to have beneficial effects on the co-morbidities typical of elderly populations. Furthermore, the epigenetic effects of diet on the aging process – through calorie restriction and the consumption of foods like
have attracted scientific interest. Some, such as
are being promoted as anti-aging foods, due to their anti-oxidative and anti-inflammatory properties.
Finally, an important moderator in the relationship between diet, longevity and human health remains the socio-economic status of individual, as a healthy diet, due to its higher cost, is closely related to higher financial and educational status.”
In a new study, researchers identified a new drug based on a component of grape seed extract that has successfully extended the life span and healthspan of mice.
The research, which appears in the journal Nature Metabolism, lays the groundwork for further clinical studies to determine whether or not the effects may be reproducible in humans…”