Myeloma Cancer Coaching- Glucose/Sugar, MGUS, SMM and Myeloma

Share Button

“…there was no association between self reported diabetes and multiple myeloma [], whereas the highest level of postload glucose was associated with risk of mortality from multiple myeloma”

Question: There is plenty of information on the impacts of refined sugar on health and also cancer in general.  Have you found any studies regarding sugar intake as it relates specifically to MGUS, SMM, or MM? Allan


Hi Allan- 

“There is plenty of information on the impacts of refined sugar on health and also cancer in general.  Have you found any studies regarding sugar intake as it relates specifically to MGUS, SMM, or MM?”  
 
You have asked an interesting question. After all the research I’ve done regarding MM and nutrition, fruits and veggies, etc. You’d think I would be able to answer your question in a snap. But I can’t answer it directly… but I can find information that points to several issues related to blood glucose/sugar- dexamethasone (steroids), diabetes, insulin and inflammation.  
 
So no, to answer your question, I have not found any studies regarding sugar intake as it relates specifically to MGUS, SMM and MM. But there are many studies that cite issues related to blood glucose/sugar and MM. 
 
I have linked several articles below. Yes, sugar is an issue with MM but the studies talk in general terms about glucose, diabetes, and insulin and inflammation. Sugar and MM is not addressed specifically as far as I can read. But I think its safe to say that refined sugar is to be avoided by MMers. At all stages. 
Let me know if you have any questions. 
 
thanks
 
David Emerson
  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Dexamethasone and blood sugar levels-

Dexamethasone is used in most myeloma therapy combinations but long-term use can affect both non-diabetics and diabetics alike. For those on the edge of the blood sugar fence, it can tip them over into Type 2 diabetes. Here are some tips to regulate your blood sugar while on dex: 1. Lower the amounts of simple carbs you consume per day. This includes white rice, white breads, candy, sugar and sugary drinks. These spike blood sugar levels and can cause chronic hyperglycemia. Use complex carbs instead: brown rice, brown pasta, etc. 2. According to Livestrong, consuming less food may be in order when on Decadron…

Multiple Myeloma and Diabetes

Multiple reports have linked diabetes to increased risk of cancer mainly pancreatic, liver, colon, breast, and endometrial cancer []. In a phase 3 Apex trial in patients with relapsed multiple myeloma by Richardson et al., 18% patients had either a baseline glycosylated hemoglobin higher than normal upper level or a history of diabetes []. In other reports, the prevalence was between 11% and 22% [, ]. 

Is there evidence about a causal relationship? Although results in the literature are contradictory, in a recent study conducted by Khan et al. there was no association between self reported diabetes and multiple myeloma [], whereas the highest level of postload glucose was associated with risk of mortality from multiple myeloma (HR, 3.06; 95% CI, 1.05–8.93) in another study by Chiu et al. []…”

Insulin Therapy Tied to Increased Death Risk for Multiple Myeloma Patients

No conclusion about causal relationships can be made at this time,” the study authors wrote. “Managing hyperglycaemia with non-insulin regimens should be investigated in randomized trials.”

Pro-Inflammatory State of MGUS and Myeloma Patients Presenting with a Monoclonal Immunoglobulin Specific for an Infectious Pathogen

Conclusion: Except for 4 cytokines, inflammation was found to be similar in MGUS and in MM. In both MGUS and MM, mc IgG were hyposialylated, and mc IgG specific for an infectious pathogen had the lowest level of sialylation. Hypo-sialylation of mc IgGs was concomitant with increased levels of cytokines that play a major role in inflammation and anti-microbial response. Altogether, these findings are consistent with infection, inflammation and abnormal immune response playing an important role in the pathogenesis of subsets of MGUS and MM…”

Leave a Comment: