Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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I was diagnosed with multiple myeloma (MM) in 2/94. I underwent extensive myeloma chemotherapy regimens. Several years of surgery, radiation, and chemotherapy led to remission, relapse, remission, relapse and my oncologist telling me “there is nothing more we can do for you” in 9/97. I wish I knew about omega-3 fatty acids at the time…
I underwent antineoplaston therapy (ANP) at the Burzynski Research Institute from 11/97-4/99. I went from end-stage multiple myeloma to complete remission in seventeen months. I’ve often wondered what I would do if I relapsed. After all, myeloma always relapses.
I’m writing this blog post on 5/20/15. In 16 + years since I reached complete remission I’ve never relapsed. I read studies like the one linked and excerpted below and I wonder if my supplementation of omega 3 fatty acids among others helps keep me in complete remission from my multiple myeloma.
According to the research linked and excerpted below, omega-3 fatty acids, fish oil, is the ideal integrative therapy. Omega-3 is cytotoxic to multiple myeloma and at the same time, it makes MM cells more sensitive to revlimid chemotherapy.
If you would like to find out more about omega-3 fatty acids and how they positively impact myeloma treatments, sign up for my free webinar about the multiple myeloma cancer coaching program by clicking the registration button on the right hand side of the page.
There is a long and growing list of research studies that show how omega 3 fatty acids kills multiple myeloma and enhances Velcade. I supplement with omega 3 fatty acids (fish oil), curcumin and resveratrol among others. I have put together a complete cancer coaching guide that outlines the evidence-based protocols I follow to stay multiple myeloma-free and manage my side effects.
I am both a long-term MM survivor and MM cancer coach. I supplement with and recommend Life Extension Super Omega 3 for several reasons. Omega 3 fatty acids promote brain, heart and blood health in addition to being cytotoxic to MM. I consider LE Super Omega 3 to be evidence-based, non-toxic chemotherapy.
“Exposure to EPA and DHA induced apoptosis and increased sensitivity to bortezomib in MM cells.
EPA and DHA inhibited NFκB activity and induced apoptosis through mitochondrial perturbation and caspase-3 activation. Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib and calls for further exploration into a potential application of these n-3 polyunsaturated fatty acids in the therapy of MM.”
Omega 3 fatty acids
Hi MM Coach– I was recently diagnosed with Multiple Myeloma. I have begun (multiple myeloma chemotherapy) induction therapy with RVd (Revlimid, Velcade and Dexamethasone). I have read about adding curcumin to enhance Velcade and fish oil to enhance the bioavailability of curcumin. My oncologist is skittish about what omega 3 (fish oil) will do to the Revlimid.
I’m seeing a very few if any articles about fish oil (omega 3 fatty acids) negating to some degree Revlimid’s action on T cells but also the positive interaction of Velcade with fish oil. Any thoughts? Steve
I am sorry to read of your Multiple Myeloma diagnosis. Keep in mind that there is a long and growing list of both conventional (FDA approved) and evidence-based non-conventional MM therapies that studies show enhance the efficacy of conventional chemotherapy. I will email you the integrative therapies guide from the MM CC program to your email address-
I understand that conventional oncologists are often “skittish” about nutritional supplementation during the administration of conventional therapies. And the final decision has to be yours, of course. All I know is that all conventional MM therapies stop working after a time (multi-drug resistence) and numerous studies document how supplements such as curcumin enhance the efficacy of chemo. Your call.
1) You are correct- this article documents only 4 interactions with rev. and fish oil- the study does not specify they type of cancer-
2) omega 3 fatty acids have been shown to be apoptotic to MM and to enhance chemo to MM-
3) Regarding Velcade- yes, curcumin and enhances the anti-MM action of Velcade-
4) lastly, you are correct, curcumin is difficult to get into the blood stream. There are several formulas/brands, that research has shown are many times more bioavailable. I take a brand called Life Extension Super BioCurcumin. Scroll down the page to read about the most bioavailable curcumin formulas.
To learn more about evidence-based, non-conventional, non-toxic therapies, managing and alleviating side effects, and overall structuring your life to support your body and fight Multiple Myeloma, please watch the video below:
“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”
A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.“
“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.
The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.
Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.
Based on the published reports,
exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”
According to Consumerlab.com:
“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”
I’m a long-term cancer survivor living with chemobrain, chemo-induced heart damage, radiation-induced nerve damage and a risk of treatment related secondary cancers. I believe that omega 3 fatty acid supplementation helps me maintain my health each and every day.
I take one capsule daily of Life Extension Super Omega 3 EPA/DHA with Sesame Lignans and Olive Fruit to insure all I get all of the health benefits below and I encourage you to do so as well.
Metabolic syndrome is a collection of conditions.
It is a major public health concern, since it increases your risk of developing many other diseases. These include heart disease and diabetes (51).
Inflammation is incredibly important. We need it to fight infections and repair damage in the body.
Cancer is one of the leading causes of death in the Western world, and omega-3 fatty acids have long been claimed to reduce the risk of certain cancers.
Asthma is a chronic lung disease with symptoms like coughing, shortness of breath and wheezing.
Menstrual pain occurs in the lower abdomen and pelvis, and often radiates to the lower back and thighs.
Good sleep is one of the foundations of optimal health.
Omega-3s can also protect your skin from sun damage. EPA helps block the release of substances that eat away at the collagen in your skin after sun exposure (101).