What I wish I knew about Multiple Myeloma treatments 25 years later...

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Myeloma Coaching- Can I Manage my MM w/ Non-toxic Therapies Only?

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Curcumin exerts a cytotoxic effect additive to that of lenalidomide on H929 myeloma cells, and it also enhances the chemo-sensitizing effects of this agent…

Hi David- How can I maintain my multiple myeloma with evidence-based non-conventional therapies. My MM is at reasonably early stages. PARA PROTEIN 29-31. No CRAB symptoms. Diagnosed 7 months ago, my oncologist wanted to give me conventional treatment. But I want to maintain my MM through evidence-based but non-toxic therapies.

So please help guide and advise. I will be most indebted to you. Thanks. Mark


Hi Mark-

I will write out a therapy plan for you. Please be sure to ask any questions you have.
Do you know levels such as total protein, serum calcium, m-spike, freelight chain levels, etc.? This information would help me with the therapy plan below. Let me know.
Overall, the point of evidence-based therapies from the MM CC guides is the synergy among therapies as being cytotoxic to MM. Yes, their are MMers who control their MM with one therapy- curcumin- but your odds are much better if you combine non-toxic therapies.

Stage 1- Pre Habilitation: By undergoing anti-MM/anti-angiogenic nutrition, supplementation, and complementary therapies you will slow and perhaps reduce your MM to a managable level without the use of conventional therapies. Further, by pre-habilitating, you will be weakening your MM such that if you do choose to undergo conventional therapies sometime in the future, you will 1) respond better to the therapy and 2) experience fewer if any adverse events aka side effects and 3) be able to reduce the amount of conventional therapy if you choose, to reduce the toxicity you undergo.

Supplementation- I continue to take and recommend curcumin, resveratrol, omega 3 and green tea extract. The dose I take and recommend is what’s on the bottle. Let me know if you would like suggestions about different brands to take.
I work with many others who take more therapies. There are 18 different theapies listed in the supplementation guide. I’m just explaining what I do and have done for years now.
Nutrition- please watch the video of Dr. Bill Li’s TED TALK. I include anti-angiogenic foods and supplements daily. Curcumln, resveratrol, green tea of course, but also (depending what’s in season) black/ red rasberries, strawberries, blueberries, orange/grapefruit, garlic, etc. etc. I may overdue it on the anti-angiogenic foods but my wife is a chef and I like to eat the foods and spices listed in Dr. Li’s Talk.
My point here is that anti-angiogenic foods and supplements are an easy way to get therapies into your body. Dr. Li calls these foods/spices/supplements a form of non-toxic chemotherapy. Studies show that curcumin (turmeric) is more effective than revlimid.
Bone Health– please read this guide- there are a number of supplements listed to strengthen bones that are also anti-angiogenic and also are listed in the mind-body guide as being anti-depressive. Consider supplementing with curcumin, resveratrol, green tea extract at a minimum.
If you currently don’t have any bone pain, please keep in mind that 90% of all MMers experience bone damage at some point during their MM experience. To a large degree you are building your bones now for problems that you may have years from now.
Mind-body therapies-  Please read this guide– Frequent, moderate exercise is mentioned many times throughout the MM CC guides- exercise is Immune boosting, bone strengthening, mind-body therapy. You might even drop a pound or two by incorporating moderate exercise into your day.
CBD oil- no THC- calming, bone strengthening, anti-angiogenic-
Detoxifying- If you can find a sauna convient to your home. I encourage frequent whole body hyperthermia aka sauna aka sweating. The studies linked in the guide support the practice.
Integrative Therapies- I understand that you would like to successfully manage your MM exclusively with non-toxic therapies however I have learned to always have a back-up plan, a plan B, when talking about MM management. If you read the integrative therapies guide you will get a sense of how MM chemotherapy regimens can be enhanced and/or minimized.
I will stop here for now. I am not saying that the info in the other guides are not important, I am saying that incorporating the therapies above may take some real effort on your part so we will stop here for now.
Mark- if you can add the above therapies to your daily regimen you may halt or reduce your MM. As I said above, if you cannot reduce your MM over the coming months you are pre-habilitating. Your MM will respond if you ever need to undergo low-dose therapy. But we can discuss that later.
I can get a much better idea of your current MM status if I can see your blood work- CBC, SPEP, etc. You said that your MM is early stage but that’s all I know right now. Let me know.
Hang in there,


New Insights in Anti-Angiogenesis in Multiple Myeloma

” This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of multiple myeloma…”

Cancer Prehabilitation Improves Outcomes

“Cancer prehabilitation is emerging as a method of better preparing patients for the often toxic and disabling effects of cancer treatment. Its place within the continuum of cancer care is rapidly being established…”

Curcumin enhances the cytotoxic and chemo-sensitising effects of lenalidomide in human multiple myeloma cells

Conclusion: Curcumin exerts a cytotoxic effect additive to that of lenalidomide on H929 myeloma cells, and it also enhances the chemo-sensitizing effects of this agent…”


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