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Myeloma, Coffee and your Gut
What is the relationship between myeloma, coffee and our gut? I am both a MM survivor and coffee drinker so the study below jumped out at me. My question is what is the benefit of L. asaccharolyticus ?
What is the health benefit of L. asaccharolyticus in your gut?
1. Role in Fiber and Protein Metabolism
- L. asaccharolyticus specializes in breaking down non-carbohydrate compounds, particularly amino acids and proteins, into simpler substances. This metabolic activity contributes to maintaining balance in the gut microbiome, especially in individuals consuming a high-protein diet.
2. Short-Chain Fatty Acid (SCFA) Production
- Although it is not a primary SCFA producer like Lactobacillus fermentum, its interactions with other microbes in the gut may indirectly support SCFA production. SCFAs, such as butyrate, are essential for maintaining intestinal barrier integrity and reducing inflammation.
3. Immune Modulation
- Certain strains of Eubacterium are known to influence the immune system positively by stimulating regulatory T cells, potentially reducing inflammation and enhancing the gut’s immune response.
4. Antimicrobial Effects
- L. asaccharolyticus competes with harmful pathogens for resources in the gut environment, helping to maintain a healthy microbiota balance and prevent overgrowth of pathogenic bacteria.
5. Maintaining pH Balance
- By fermenting amino acids and proteins, it may contribute to producing metabolites that help maintain an acidic pH in the colon, which is inhospitable to many pathogens.
Coffee- who knew???
I, like many MM survivors, take a probiotic daily. My understanding is is that L. asaccharolyticus is not contained in my daily capsule. But my moderate coffee drinking (2-3 cups at breakfast), according to the research below, grows it in my gut.
Each and every health benefit listed above is helpful for my ongoing MM survivorship however of particular benefit to all of us MM ers is 3. immune modulation. I need all the t cells I can get after all of the aggressive chemo I’ve had.
Email me at David.PeopleBeatingCancer@gmail.com with questions about myeloma, coffee and your gut.
Thank you,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood.
Coffee is a habitually consumed beverage with established metabolic and health benefits. We previously found that coffee is, among >150 items, the food showing the highest correlation with microbiome components.
Here we conducted a multi-cohort, multi-omic analysis of US and UK populations with detailed dietary information from a total of 22,867 participants, which we then integrated with public data from 211 cohorts (N = 54,198).
The link between coffee consumption and microbiome was highly reproducible across different populations (area under the curve of 0.89), largely driven by the presence and abundance of the species Lawsonibacter asaccharolyticus.
Using in vitro experiments, we show that coffee can stimulate growth of L. asaccharolyticus. Plasma metabolomics on 438 samples identified several metabolites enriched among coffee consumers, with quinic acid and its potential derivatives associated with coffee and L. asaccharolyticus. This study reveals a metabolic link between a specific gut microorganism and a specific food item, providing a framework for the understanding of microbial dietary responses at the biochemical level…
Impact of coffee on the gut microbiome
Researchers conducted what they believe to be the largest study to date on the connection between coffee consumption and the human gut microbiome.
They utilized data from several sources, including:
- five ZOE PREDICT cohorts
- the Mind–Body Study (MBS)
- the Men’s Lifestyle Validation Study (MLVS)…
Participants were then categorized into three levels of coffee consumption:
- never-consumers, if they had up to 20 grams (g) of coffee a day, or less than 3 cups a month
- moderate consumers, if they had between 21–599 g of coffee per day
- high consumers, if they had 600 g or more of coffee per day, or more than 3 cups a day…
The researchers then used machine learning to see how coffee drinking relates to the types and levels of bacteria in our gut. They trained a computer program to identify differences in the gut bacteria…
The median abundance of L. asaccharolyticus was shown to be significantly greater in the high coffee consumption group, with values ranging from 4.5 to 8 times more than in the never group.
Similarly, the moderate consumption group exhibited 3.4 to 6.4-fold greater levels than the never group.
Analyses of blood metabolites showed that compounds like quinic acid and trigonelline were also particularly prevalent in coffee drinkers, correlating with higher L. asaccharolyticuslevels…
Overall, this research adds to the evidence that coffee alters the gut microbiome’s composition, with L. asaccharolyticus being particularly responsive to coffee intake…”
myeloma coffee and our gut myeloma coffee and our gut