Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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If you have been diagnosed with multiple myeloma, an incurable blood cancer, your first mental hurdle will be to consider all of your therapy options. Conventional or traditional oncology can’t figure out how to cure your disease. Curcumin has been shown to increase the efficacy of multiple myeloma chemotherapy while it decreases the risk of side effects.
While the FDA has approved a long and growing list of MM chemotherapy regimens, according to the ACS, the average five year survival of MM patients is 49%. It is in your interest as an MM patient to achieve the longest and deepest remissions while experiencing the fewest side effects possible.
That’s the bad news. Now the good news. According to the studies linked and excerpted below, thalidomide
More good news. I was diagnosed with MM in early 1994. I underwent about 4 years of conventional therapies including an autologous stem cell transplant. After remission, relapse, remission, and relapse my oncologist told me that nothing more could be done for me. Nothing personal, this happens to almost every MMer at some point.
The bottom line is whether you are a newly diagnosed MMer or a MM survivor looking for another therapy and another remission please consider combining conventional and evidence-based, non-conventional therapies.
Keep in mind that curcumin is nortoriously difficult to absorb. Scroll down to read about the most bioavailable curcumin formulas.
To learn more about these evidence-based, non-conventional therapies and how they can positively impact your conventional therapies, please watch the video below:
“An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer…”
“Thalidomide combined with palonosetron (Aloxi) and dexamethasone significantly improved delayed nausea and vomiting in chemotherapy-naïve patients who received highly emetogenic chemotherapy (HEC), according to researchers in China…
Rates of no nausea were also higher in the thalidomide group. The thalidomide group had less insomnia, lower anorexia scores, and demonstrated better quality of life after chemotherapy, but had increased constipation, dizziness, sedation, and dry mouth…
In an accompanying editorial, Kathryn Ruddy, MD, and Charles Loprinzi, MD, both of the Mayo Clinic in Rochester, Minn., and Rudoph Navari, MD, of the University of Alabama in Birmingham, wondered whether thalidomide is likely to become an established antiemetic agent after the results of this study…”
“We show here that curcumin may act as a steroid-sparing agent in patients with MM who are intolerant of Dex. We demonstrate that curcumin in combination with other antimyeloma therapies was able to reduce paraprotein load by 38% and plasmacytosis by 59% over this study period. Multiple myeloma is a heterogenous disease from a cytogenetic abnormalities point of view.24 Eight of the 15 patients demonstrated high-risk cytogenetic and FISH abnormalities with many of these showing evolution during the course of their illness. While three patients died during the course of this study, none of these had high-risk cytogenetic abnormalities. Some of the surviving patients do have high-risk cytogenetic and FISH abnormalities and despite this, continue to do well on the combination therapy.
This is the first reported case series of patients with MM who have been treated with adjuvant curcumin as opposed to Dex in combination with other antimyeloma agents.
Curcumin-based combination therapies may be capable of stabilizing disease progression without the adverse effects associated with steroid use.
In our experience, the only observed side effect of curcumin is diarrhea which can be managed by either temporarily suspending therapy or reducing the dose. Therefore, curcumin can be considered to have comparatively minimal adverse effects and superior tolerability to typical steroid medications, such as commonly used dexamethasone.
Curcumin has been reported to induce anticancer and antiproliferative activity via multiple pathways including induction of apoptosis by caspase activation, downregulation of essential transcription factors like NF-kB, inhibition of c-Jun N-terminal kinase (JNK), and protein tyrosine kinases and downregulation of growth factor receptors like HER2 and EGFR.10 Banerjee et al19 establish that impairment of proteasome activity by DYRK2 inhibition is a major mechanism of action for curcumin in the context of the alleviation of proteasome-dependent neoplastic malignancies such as MM…”
“Collectively, our results suggest that curcumin overcomes chemoresistance and sensitizes MM cells to thalidomide and bortezomib by downregulating NF-κB and NF-κB-regulated gene products…
“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”
A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
I consult the independent evaluation service Consumerlab.com frequently. For one low annual payment, I can read about and evaluate all of the nutritional supplement that I take.
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.“