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Myeloma, PEMF, Radiation Bone Loss
Radiation-induced bone loss is a serious problem for multiple myeloma survivors. Radiation can be effective at eliminating bone lesions. However, radiation can then cause bone loss having cause osteoclast formation to stop.
Radiation was effective at eliminating the lesions growing in my iliac crest. Terrific! Unfortunately, this therapy caused serious bone and nerve damage that would handicap me in the years following my conventional therapies.
As I often lament, “I wish I knew then what I know now.” Both PEMF and HBOT therapies would have prevented or dramatically reduced the damage caused by my radiation therapy.
Does Pulsed Electromagnetic Fields prevent radiation-induced bone loss?
Yes, there is evidence that Pulsed Electromagnetic Fields (PEMFs) can mitigate radiation-induced bone loss- Studies have shown that PEMFs can positively influence bone remodeling and help counteract bone density loss caused by radiation.
Key Points from Research:
- Mechanisms of Action:
- PEMFs stimulate osteoblast activity (bone-forming cells) while reducing osteoclast activity (bone-resorbing cells), promoting bone regeneration and minimizing bone loss.
- They improve microcirculation and promote angiogenesis (formation of new blood vessels), which can enhance the healing environment in bone tissue.
- Radiation Effects on Bone:
- Radiation exposure often leads to decreased bone density, increased risk of fractures, and suppression of normal bone cell activity due to oxidative stress and inflammation.
- PEMFs have been reported to reduce oxidative stress and inflammation, which may help protect bone tissue from radiation damage.
- Preclinical and Clinical Evidence:
- Animal Studies: Research on animal models has demonstrated that PEMF therapy reduces bone loss and improves bone microarchitecture following radiation exposure.
- Human Studies: While direct studies on radiation-induced bone loss in humans are limited, PEMFs are already used to treat conditions like osteoporosis and fracture non-unions, suggesting their potential for broader applications, including radiation-induced bone conditions.
PEMF for bone health
Bone health/strength is an ongoing pursuit of MM patents. MM itself can weaken your bones. Chemo, dexamethasone, etc. can weaken bones. And yes, radiation therapy weakens bone. A possible therapy then, can be PEMF.
Email me at David.PeopleBeatingCancer@gmail.com with questions about non-conventional bone health therapies.
Hang in there,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field
“Abstract- Radiotherapy increases tumor cure and survival rates; however, radiotherapy-induced bone damage remains a common issue for which effective countermeasures are lacking, especially considering tumor recurrence risks.
We report a high-specificity protection technique based on noninvasive electromagnetic field (EMF). A unique pulsed-burst EMF (PEMF) at 15 Hz and 2 mT induces notable Ca2+ oscillations with robust Ca2+ spikes in osteoblasts in contrast to other waveforms.
This waveform parameter substantially inhibits radiotherapy-induced bone loss by specifically modulating osteoblasts without affecting other bone cell types or tumor cells. Mechanistically, primary cilia are identified as major PEMF sensors in osteoblasts, and the differentiated ciliary expression dominates distinct PEMF sensitivity between osteoblasts and tumor cells.
PEMF-induced unique Ca2+ oscillations depend on interactions between ciliary polycystins-1/2 and endoplasmic reticulum, which activates the Ras/MAPK/AP-1 axis and subsequent DNA repair Ku70 transcription. Our study introduces a previously unidentified method against radiation-induced bone damage in a noninvasive, cost-effective, and highly specific manner…
DISCUSSION-
Radiotherapy-induced bone damage represents an increasingly important clinical challenge. However, effective countermeasures are still lacking, especially considering the risk of tumor recurrence.
Following radiotherapy, many patients fail bone treatment, which leaves them at a substantially higher risk of fragility fractures and osteonecrosis (42). Here, on the basis of a systemic parameter optimization through Ca2+ dynamics analyses, we identified a previously unidentified PEMF waveform at 15 Hz and 2 mT that effectively resisted radiation-induced bone loss by inducing the specific activation of osteoblasts with no impact on tumor cells…
Pulsed Electromagnetic Fields (PEMFs) Trigger Cell Death and Senescence in Cancer Cells
“The currently available anti-cancer therapies, such as gamma-radiation and chemotherapeutic agents, induce cell death and cellular senescence not only in cancer cells but also in the adjacent normal tissue. New anti-tumor approaches focus on limiting the side effects on normal cells…
In conclusion, PEMF irradiation is a promising pre-conditioning, non-invasive strategy for tumor elimination, limiting the side effects of traditional radiotherapy (Figure 6A), as revealed by our findings. PEMF-treated cancer cells not only displayed cell death but also senescence. In contrast, normal fibroblasts were not affected by the possible harmful effects of PEMFs, but increased their cellular viability (Figure 3C). These findings suggested that PEMFs reduced the viability of cancer cells without having side effects on the adjacent normal tissue (Figure 6B), an outcome that is observed during traditional radiation therapy…”
myeloma PEMF radiation bone loss myeloma PEMF radiation bone loss