Hello David- thank you for your video and links and this article. I am a Multiple Myeloma patient (myeloma remission) and have been successful in killing the Monoclonal protein within 4.5 months with medical cannabis and 9 months of oncology treatment with bortezomib (velcade) and other meds.
I started my cannabis on Dec 30, 2018 3 days after diagnoses and continued using it up until my first chemo treatment on March 1 2019. I continue to use it today and by April 26, 2019. All cancer was undetected. I am in complete remission from my multiple myeloma!
I have a video on youtube about my journey, simply search my name, Denise Mazur. Thank you, I will be sharing this to my facebook group called “multiple myeloma and cannabis”.
As you know, the research linked in the blog post talked about the ability of CBD oil to enhance the efficacy of Velcade (Bortezomib). And you say that CBD with Velcade was your induction therapy and you have reached complete remission. EXCELLENT!
- Do you know your stage of MM at diagnosis?
- Did you have any bone damage? Bone pain? CBD oil has also been shown to heal bone fractures.
- MM patients frequently ask me the dose of CBD they should take to kill their MM. Do you know what strain and the percentage of cannabinoids in your CBD oil? Did you take any other conventional medications such as dexamethasone or bisphosphonates (bone strengthening drugs)?
- Is there any THC in your CBD oil?
“Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM). Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor.
TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells. However, no functional role has been ascribed to CBD and TRPV2 in MM.
In this study, we identified the presence of heterogeneous CD138+TRPV2+ and CD138+TRPV2- PC populations in MM patients, whereas only the CD138+ TRPV2- population was present in RPMI8226 and U266 MM cell lines.
Because bortezomib (BORT) is commonly used in MM treatment, we investigated the effects of CBD and BORT in CD138+TRPV2- MM cells and in MM cell lines transfected with TRPV2 (CD138+TRPV2+). These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells.
These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM.”
“Helps with cancer drugs. Sometimes, your multiple myeloma may become resistant to certain drugs. This means that your medication may not work as well as it used to. In lab studies, researchers found that medical marijuana may help lower resistance to multiple myeloma drugs, but that hasn’t been tested in people. Bortezomib (Velcade), or “BTZ,” is a drug that treats multiple myeloma. Experts found that it controls your cancer more when you use it in combination with CBD. When they’re used together, they kill more cancer cells.
Similarly, some research suggests another multiple myeloma drug, called carfilzomib (Kyprolis), might work better with medical marijuana. Experts found this medication, when combined with a mix of CBD and THC, may work better than when it’s used alone.
More studies are looking at how cannabinoids can help treat multiple myeloma and other cancers. Talk to your doctor about whether medical marijuana is right for you…”
