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Myeloma, Vitamin D and Gut Health
Myeloma, vitamin D, and gut health are linked according to the Medscape article linked below. And if you are an MM patient, you may already be supplementing with vitamin D.
However, the article below highlights several issues that may be central to a myeloma survivor’s understanding of vitamin D.
This video cites several vitamin D concepts that are central to managing multiple myeloma.
Vitamin D Actually Feeds Your Microbes
Reasons to supplement with vitamin D-
- Vitamin D- Myeloma side effect prevention
- Myeloma and Vitamin D3
- Vitamin D Therapy for health, happiness-
- Collagen, Vitamin D3 for Heart Health?
I am a long-term MM survivor. It is remarkable to me to learn about an MM therapy that is inexpensive, easy, and evidence-based.
Email me at David.PeopleBeatingCancer@gmail.com if you’d like to learn more about managing your MM.
Thank you,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
The Overlooked Link Between Vitamin D and GI Health
“Vitamin D is a fat-soluble vitamin long associated with bone health, but emerging evidence is revealing that it has a broader role, particularly in gut health. Both animal and human studies have linked low vitamin D levels with a variety of gastrointestinal (GI) diseases, including:
- inflammatory bowel disease (IBD),
- diverticulitis,
- colon cancer, and
- Liver disease.
Biologic Effects on the Gut
Vitamin D is synthesized in the skin following sun exposure and is then transported to the liver and kidneys for transformation into its biologically active form. Although dietary intake and supplementation contribute to vitamin D status, sunlight remains the primary source.
Vitamin D deficiency has been implicated in altering the gut microbiome composition, compromising intestinal mucosal barrier integrity, and predisposing individuals to various intestinal pathologies.
In the intestines, vitamin D binds to vitamin D receptors present in immune cells, which play a crucial role in immune function. Vitamin D affects the gene function responsible for modulating inflammation; cell proliferation; and the-
- development,
- progression, and
- migration/metastasis of neoplasia.
Vitamin D receptors also exert regulatory control, via signal transduction pathways, over the intestinal microbiome in both healthy and disease states.
Studies have found that vitamin D supplementation can improve the diversity and stability of the fecal microbiome…
Dose and Supplementation
Most experts define a vitamin D level of < 50 nmol/L as indicating a risk for insufficiency and of < 30 nmol/L as indicating a risk for deficiency. However, it should be noted that the recent recommendations from the Endocrine Society do not suggest specific levels to define vitamin D insufficiency and deficiency.
There are two main dietary forms of vitamin D: D2, which is primarily found in plants and fungi, and D3, which is animal-derived. Although both contribute to overall vitamin D levels, the latter is significantly more effective in raising serum levels.
Testing for the biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is recommended to more accurately identify deficiency.
Although dietary intake of vitamin D-rich foods remains a cornerstone recommendation, supplementation may be required in patients whose levels remain inadequate despite these efforts, or among those considered to be at particularly high risk.
Evidence supports daily supplementation with up to 2000 international units (IU), preferably with vitamin D3, to prevent and/or treat vitamin D deficiency.
According to large randomized controlled trials, there are no significant safety concerns in supplementing such a dose for several years, even in individuals with an already sufficient vitamin D status at baseline. A daily supplementation with 2000 IU can be considered a simple, effective, and safe dosage to prevent and/or treat vitamin D deficiency in the general adult population. ..
Given the strong association between low vitamin D levels and inflammatory and/or neoplastic disease, as well as the extraordinarily low risk profile of supplementation, practitioners should consider targeted testing or empiric treatment as part of their GI disease management and risk-reduction strategies.”
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