Diagnosed with SMM, SPB, or MGUS?

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Single Plasmacytoma, MGUS, SMM Demystified

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Plasmacytoma, MGUS and SMM Defined- Symptoms, Causes, Diagnostics-

Hi. My name is David Emerson. I am a the Director of PeopleBeatingCancer, long-term Multiple Myeloma survivor and Multiple Myeloma cancer coach. This blog post is designed to outline the basics of the “pre-MM” blood disorders of a single plasmacytoma, MGUS and SMM. My experience as a cancer survivor and cancer coach is that the more completely someone understands their diagnosis the more in control they will feel. The more in control you feel the greater your quality and length of life.

Have you been given a diagnosis of a single plasmacytoma, MGUS or SMM? Are you experiencing any symptoms? Do you want to learn more about evidence-based, non-toxic therapies? Scroll down the page, post a comment or a question and I will reply to you ASAP.

multiple myeloma in bone marrow

The first thing that you must understand about a diagnosis of a single plasmacytoma, MGUS or SMM is that they are NOT cancer. They are blood disorders or pre-cancer stages. The second thing that you should understand about your blood disorder is that you do not have to “watch and wait.” Yes, regular diagnostic testing to keep an eye on your health is a good idea but there are steps you can take to reduce your risks of a full-blown diagnosis of multiple myeloma.

To learn more about the evidence-based therapies you can follow to manage your pre-Myeloma and prevent full-blown Myeloma from developing, please watch the short video below:

Click here to get the FREE Pre-Myeloma Introduction Guide and follow along.

Click here to get the FREE Pre-Myeloma First Questions Guide.

Each area of interest below is linked to specific information for you to pursue if you choose to.

Single Plasmacytoma

Plasmacytoma refers to plasma cell tumor growing within soft tissue or within the axial skeleton…Solitary Plasma of the Bone (SPB) and extramedullary plasmacytomas are mostly treated with radiotherapy, but surgery is used in some cases of extramedullary plasmacytoma.


Serum protein electrophoresis of an individual with polyclonal antibodies (top) and an individual with a large paraprotein (bottom).

The diagnosis of plasmacytoma uses a diverse range of interdisciplinary techniques including serum protein electrophoresisbone marrow biopsy, urine analysis for Bence Jones protein and complete blood countplain film radiographyMRI and PET-CT.[10][11]


Most cases of SPB progress to multiple myeloma within 2–4 years of diagnosis, but the overall median survival for SPB is 7–12 years. 30–50% of extramedullary plasmacytoma cases progress to multiple myeloma with a median time of 1.5–2.5 years. 15–45% of SPB and 50–65% of extramedullary plasmacytoma are disease free after 10 years.[3]

Monoclonal gammopathy of undetermined significance

MGUS, is a condition in which a paraprotein is found in the blood during standard laboratory blood tests. It resembles multiple myeloma and similar diseases, but the levels of antibody are lower,[1] the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, it has no symptoms or major problems…”


MGUS is a common, age-related medical condition characterized by an accumulation of bone marrow plasma cells derived from a single abnormal clone. Patients may be diagnosed with MGUS if they fulfill the following four criteria:[4]

  1. A monoclonal paraprotein band lesser than 30 g/L (< 3g/dL);
  2. Plasma cells less than 10% on bone marrow examination;
  3. No evidence of bone lesions, anemiahypercalcemia, or renal insufficiency related to the paraprotein, and
  4. No evidence of another B-cell proliferative disorder.


At the Mayo Clinic, MGUS transformed into multiple myeloma or similar lymphoproliferative disorder at the rate of about 1-2% a year, or 17%, 34%, and 39% at 10, 20, and 25 years, respectively, of follow-up—among surviving patients…

Smouldering Multiple Myeloma

Smouldering myeloma is a disease which is characterised by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein).[1]


Smouldering myeloma is characterised by:[2]

  • Serum paraprotein >30 g/L AND/OR
  • Clonal plasma cells >10% and <60% on bone marrow biopsy AND
  • No evidence of end organ damage that can be attributed to plasma cell disorder AND
  • No myeloma-defining event (>60% plasma cells in bone marrow OR Involved/Uninvolved light chain ratio >100)


Smouldering myeloma with an increasingly abnormal serum free light chain (FLC) ratio is associated with a higher risk for progression to active multiple myeloma.[3]

If you do not want to “watch and wait” to see if your MGUS progresses to Multiple Myeloma scroll down the page, post a question or a comment and I will reply to you ASAP.

Consider MGUS Therapies such as:

  1. non-toxic, cytotoxic/apoptotic supplements,
  2. foods that starve multiple myeloma
  3. evidence-based mind-body therapies,
  4. detoxification therapies,
  5. Non-conventional bone health therapies
  6. Cannabis/CBD/THC oil

Thank you,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer



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