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Non-Melanoma Skin Cancer, either Basel Cell or Squamous Cell Carcinomas, are a double-edged sword. The good edge of the sword is the fact that only a small percent of NMSC’s even become melanoma that result in death.
The bad side of the sword is that non-melanoma skin cancers are common, frequently come back and can cause damage to your skin (face?) where they erupt.
Non-Melanoma Skin Cancer at a Glance-
I know. I am a cancer survivor and cancer coach of a different cancer. I underwent local radiation for my different cancer that increased my risk of non-melanoma skin cancer. Further, I had a bone marrow transplant which also increased my risk of NMSC. I have six (6) of the risk factors listed above.
I wasn’t surprised when a mole (nevis) appeared out of nowhere on my face a few years ago. Having the mole removed was quick, easy and covered by my health insurance.
But it became clear to me that non-melanoma skin cancers would recur frequently as I aged if I didn’t take steps to reduce the risks of NMSC recurrence.
I supplement with Life Extension Optimized Resveratrol with Nicotinamide Riboside. As the studies linked and excerpted below explain both nicotinamide and resveratrol reduce my risk of non-melanoma skin cancer.
I am healing the damage I’ve previously done to my skin as well as reducing the risk of treatment-related secondary cancer.
I am both a cancer survivor and cancer coach. Scroll down the page, post a question or a comment and I will reply to you ASAP.
“The prevention of common skin cancers and precancers is possible by taking an inexpensive, widely available, oral pill twice daily. The pill—the vitamin B3 supplement called nicotinamide—cut the rate of new squamous-cell and basal-cell skin cancers by 23% compared with placebo after 1 year among patients at high risk for skin cancer. Nicotinamide also reduced the risk for developing actinic keratosis, a common precancer of the skin.
The results of the phase 3 ONTRAC skin cancer prevention study were presented at ASCO 2015.
These findings have the potential to lower healthcare costs. In the United States, skin cancer accounts for approximately $4.8 million annually.
The investigators emphasized that these results were achieved in individuals who previously had skin cancer and were thus at high risk for new skin cancers. The results do not apply to other patient populations.
In addition, the investigators emphasized that nicotinamide is the form of vitamin B3 that should be taken for prevention—not other forms of vitamin B, such as niacin—and that continuous treatment is advised…
As the aging population continues to grow, basal- and squamous-cell carcinomas will become even more common than they currently are…
The present study included 386 patients aged 30 to 91 years who had ≥2 nonmelanoma skin cancers over the past 5 years, and were therefore deemed high-risk. The patients were randomized to oral nicotinamide 500 mg twice daily or to placebo for 12 months. Dr Damian said that the patient mix reflected those seen in a typical skin cancer clinic. The average age was 66 years, and 66% of the patients were men, many with ongoing chronic comorbidities…
“This preventive treatment has no side effects. Unlike niacin, another form of vitamin B3, nicotinamide does not cause headache or increased blood pressure,” Dr Damian said…”
“Photoprotection can be provided not only by ultraviolet (UV) blockers but also by oral substances.
Enhancing ATP production with oral nicotinamide protects from UV immunosuppression, enhances DNA repair and reduces skin cancer in humans. Reactive oxygen species also contribute to photodamage. Nontoxic substances consumed in the diet, or available as oral supplements, can protect the skin by multiple potential mechanisms. These substances include polyphenols in fruit, vegetables, wine, tea and caffeine-containing foods. UV-induced prostaglandin E2 (PGE2 ) contributes to photo damage…”
“Studies have shown protective effects of resveratrol against ultraviolet radiation mediated oxidative stress and cutaneous damages including skin cancer. Because many of the skin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears to have promise and prospects against a wide range of cutaneous disorders including skin aging and skin cancers…”
“Resveratrol, a phytoalexin antioxidant found in red grapes, has been shown to have both chemopreventive and therapeutic effects against many diseases and disorders, including those of the skin.
Studies have shown protective effects of resveratrol against ultraviolet radiation mediated oxidative stress and cutaneous damages including skin cancer. Because many of the skin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears to have promise and prospects against a wide range of cutaneous disorders including skin aging and skin cancers.
However, there are a few roadblocks in the way of this promising agent regarding its translation from the bench to the bedside. This review discusses the promise and prospects of resveratrol in the management of skin disorders and the associated challenges…”