Non-Secretary Multiple Myeloma

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“The study, therefore, concludes that curcumin co-treatment with Bortezomib has a potential to take care of possible side effects of Bt therapy on normal cells…”

Hi David- I was diagnosed with Non-Secretary Multiple Myeloma ( NSMM) a year ago.I did 4 cycles (of 4) Velcade/Dex/Endoxan. 10 Radiation cycles on my spine. Have relapsed and am considering an ASCT.

During my 6 months of remission I was on 8 gms Curcumin, Essiac Tea and CBD oil. I have followed a strict anti-cancer diet, meditation and exercise.

If there is any advice you can give me, it would be greatly appreciated. By grace.
Wendy


Hi Wendy-
My experience also as a non-secretory myeloma survivor is to expand the types of evidence based therapies you choose. In short, I throw everything research can find (and verify for efficacy) at my multiple myeloma. I have been in complete remission from my MM since 4/99.
Please consider combining your evidence-based non-conventional  therapies with your conventional therapies. For example, according to the studies linked and excerpted below,  curcumin is cytotoxic to myeloma and it also enhances the MM killing ability of Velcade and curcumin reduced the toxicity of Velcade. My point is that you should have been taking curcumin at the same time you were taking Velcade. Also, cannabinoids IN CBD oil also enhance Velcade. Both of these therapies integrate with Velcade.  Scroll down to learn about the most bioavailable curcumin formulas.
I understand that Velcade didn’t give you much of a remission. This is why I promote integrative therapies. I would want to discuss nutrition as well.
The Multiple Myeloma Cancer Coaching Program covers the following:
  1.  Anti- cancer supplementation and also those specific supplements that I take with brands and daily doses
  2.  Those supplements that are “integrative” with FDA approved chemotherapy. This list overlaps with the above but this form of therapy is key for cancer patients and suvivors.
  3.  Anti-cancer anti-angiogenic nutrition- I don’t believe in diets. I am talking about those foods that we can incorporate into our diets that are anti-angiogenic aka cancer killing-
  4. Bone health supplementation– bone health is important for all cancer patients. Bisphosphonate therapy is fine but there are other therapies for you to consider
  5.  Lifestyle therapies that are evidence based to kill cancer-
  6. Evidence-based mind-body therapies-
thank you,
David Emerson
  • MM Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer
” These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells. These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM…”

Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.

“Moreover, inhibiting EEF2K by either RNAi or NH125, a small molecule inhibitor of the enzyme, rendered tumor cells more sensitive to curcumin and velcade, two anticancer agents that possess ER stress-inducing action…”

Curcumin as a protector for normal cells during bortezomib therapy

“The study, therefore, concludes that curcumin co-treatment with Bt has a potential to take care of possible side effects of Bt therapy on normal cells…”

The Most BioAvailable Curcumin Formulas

“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”

A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.

I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.

The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.

The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.


Recommended Reading:


Curcumin

CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.[1]

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.

“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.

The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.

Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.

Based on the published reports,

exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”

According to Consumerlab.com:

“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”

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