Oral Submucous Fibrosis Identification and Therapy

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Oral submucous fibrosis (OSF) is a chronic, insidious disease that is associated with significant functional morbidity and an increased risk for malignancy

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OSF is a chronic disease that is 1) common among certain peoples and certain countries but 2) rare in the United States. First and foremost OSF increases your risk of oral cancers by as much as 7 percent. But when I came across a study citing curcumin as an effective, inexpensive Oral Submucous Fibrosis treatment I decided to write a post about this horrible disease.

The first article linked and excerpted below is an excellent, all encompassing discussion of oral sub mucous fibrosis. The reason why the article caught my eye is that like my cancer, multiple myeloma, OSF is considered to be incurable. However curcumin as well as other lifestyle therapies, has helped me remain cancer-free since 1999.

Perhaps curcumin supplementation will help OSF patients as much as it helps me.

For more information about nutritional supplementation, scroll down the page, post a question and I will reply ASAP.

thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Oral Submucous Fibrosis


“Some authors have found a high frequency of mutations in the APC gene and low expression of the wild-type TP53 tumor suppressor gene product in patients with OSF, providing some explanation for the increased risk of oral squamous cell carcinoma development in patients with oral submucous fibrosis…[9]”


OSF has a high rate of morbidity because is causes a progressive inability to open the mouth, resulting in difficulty eating and consequent nutritional deficiencies. OSF also has a significant mortality rate because of it can transform into oral cancer, particularly squamous cell carcinoma, at a rate of 7.6%…[4]

No specific laboratory tests are available for OSF, and abnormalities may be related to secondary nutritional deficiencies. Some OSF studies have reported the following laboratory findings:

  • Decreased hemoglobin levels
  • Decreased iron levels
  • Decreased protein levels
  • Increased erythrocyte sedimentation rate
  • Decreased vitamin B complex levels

Oral dysplasias and squamous cell carcinomas are complications of oral submucous fibrosis. In patients with oral submucous fibrosis, the risk of developing oral carcinoma is 7.6% over a 10-year period…[3]

Efficacy of curcumin in the treatment for oral submucous fibrosis – A randomized clinical trial

Introduction: OSF is a chronic, insidious disease that is associated with significant functional morbidity and an increased risk for malignancy…

Conclusion: It can be concluded that combination strategies for the management of OSF which include the stoppage of causative ill habits, appropriate medicinal and physiotherapy management is more efficient than single therapeutic modality. It is evident from the study that curcumin holds good promise in the treatment of OSF in future.”

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