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Conventional Oncology has Little to Offer the Pancreatic Cancer Patient. Think Outside the Box and Consider Conventional Therapies combined with Evidence-based Integrative, and Complementary Therapies.
I am a long-term survivor of an “incurable cancer” who pursued conventional “standard-of-care” therapies when I was first diagnosed only to experience remission, relapse, remission and, after four short years, my oncologist telling me that “there is nothing more we can do for you.” I live with a host of permanent side effects from those aggressive toxic conventional therapies.
So it is difficult for me to write about aggressive cancers such as pancreatic cancer without sounding histrionic.
2014 estimates for pancreatic cancer is 45,000 newly diagnosed patients and 40,000 cancer deaths. Early stage pancreatic cancers (I and II) can undergo surgery and improve 5 year survival rates to 16-25%. Late stage pancreatic cancer predicts 5 year survival rates of less than 5%.
If conventional oncology is your sole option, aggressive chemotherapy and radiation may result in side effects which limit the pancreatic cancer patient’s quality of life rather than increasing his/her length of life.
Conventional oncology has little to offer the later stage PC patient. Consider thinking outside the box with lower dose chemo combined with those nutraceuticals and complementary therapies such as those discussed in the studies linked below this article. To learn more about these complementary therapies:
To Learn More about non-conventional pancreatic cancer therapies please read the posts linked below-
Most importantly, your pancreatic tumor may shrink enough to then undergo Whipple surgery for your cancer.
I am both a long-term cancer survivor and cancer coach. Do you have PC? What stage? Scroll down the page, post a question or comment and I will reply to you ASAP.
“A growing body of evidence supports the idea that curcumin is a promising anticancer drug. Curcumin has anticancer effects, both alone and in combination with other anticancer drugs, through the modulation of a variety of molecular targets in preclinical models..”
“A small Phase I clinical trial in the U.S. has just shown that adding IV (intravenous) vitamin C to a common chemo drug for pancreatic cancer extended patients’ average survival time to 12 months, compared to historical survival times of 5.65 months for such patients. More remarkable is that three of the patients were still alive at the end of the trial (two at 15 months, one at 29 months survival time) which means overall survival could further increase…”
“In this first reported clinical case, exercise led to improvements in a variety of patient outcomes during adjuvant therapy for pancreatic cancer. This initial evidence has important clinical implications, indicating that exercise may be an effective adjunct therapy for the management of pancreatic cancer…”
“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”
A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.“
“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.
The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.
Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.
Based on the published reports,
exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”
According to Consumerlab.com:
“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”