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Pancreatic Cancer, Feverfew and Arsenic Trioxide

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“The active ingredients in feverfew include parthenolide.[10] There has been some scientific interest in parthenolide, which has been shown to induce apoptosis in some cancer cell lines in vitro and potentially to target cancer stem cells”

I wouldn’t be blogging about feverfew, arsenic trioxide and pancreatic cancer if conventional oncology offered any hope to pancreatic cancer patients and their caregivers. My apologies for being so direct but I only have your attention for a few seconds.

Further, I encourage you to consider integrative pancreatic cancer therapies. By integrative therapies I am refering to those evidence-based but non-conventional supplements that research has shown can enhance the efficacy of convention anti-PC therapies. A good example is curcumin and cisplatin.

I have survived a different but equally aggressive cancer called multiple myeloma by pursuing evidence-based, non-conventional therapies. It may not sound very scientific but I thrown the therapy book, so to speak, at MM each and every week. I encourage you to do the same with pancreatic cancer. There are many evidence-based, non-conventional, non-toxic nutritional supplements that kill PC individually or in combination with conventional PC chemotherapy.

Have you been diagnosed with pancreatic cancer? Please scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.

“Results-The combination of PTL and ATO inhibited the growth of pancreatic tumor cell lines much greater than each agent alone. The PTL/ATO treatment induced apoptosis and reactive oxygen species generation. Both of them were inhibited by L-N-acetylcysteine and diphenylene iodonium chloride. During ATO/PTL-mediated apoptosis, the collapse of mitochondrial transmembrane potential occurred with cytochrome c release, which was reversed by L-N-acetylcysteine. The combination treatment significantly reduced tumor growth rates of PANC-1 xenografts compared with those treated with either PTL or ATO alone.

CONCLUSIONS: Combination therapy with ATO and PTL has an augmented anticancer effect on pancreatic cancer in vitro and in vivo, which provides a novel promising approach in the treatment of pancreatic cancer. The mechanism of growth-suppressive effect of combination therapy was correlated with its ability to induce reactive oxygen species generation and apoptosis via the mitochondrial pathway.

Feverfew (Tanacetum parthenium L.): A systematic review

“The feverfew herb has a long history of use in traditional and folk medicine, especially among Greek and early European herbalists. Feverfew has also been used for psoriasis, allergies, asthma, tinnitus, dizziness, nausea, and vomiting. The plant contains a large number of natural products, but the active principles probably include one or more of the sesquiterpene lactones known to be present, including parthenolide. Other potentially active constituents include flavonoid glycosides and pinenes. It has multiple pharmacologic properties, such as anticancer, anti-inflammatory, cardiotonic, antispasmodic, an emmenagogue, and as an enema for worms.

In this review, we have explored the various dimensions of the feverfew plant and compiled its vast pharmacologic applications to comprehend and synthesize the subject of its potential image of multipurpose medicinal agent. The plant is widely cultivated to large regions of the world and its importance as a medicinal plant is growing substantially with increasing and stronger reports in support of its multifarious therapeutic uses…”

Tanacetum parthenium

Tanacetum parthenium, known as feverfew[1] or bachelor’s buttons,[2] is a flowering plant in the daisy family Asteraceae. It is a traditional medicinal herb which is commonly used to prevent migraine headaches, and is also occasionally grown for ornament. It is also commonly seen in the literature by its synonyms, Chrysanthemum parthenium and Pyrethrum parthenium

The active ingredients in feverfew include parthenolide.[10] There has been some scientific interest in parthenolide, which has been shown to induce apoptosis in some cancer cell lines in vitro and potentially to target cancer stem cells.[11][12][13] There are no published in vivostudies of parthenolide or feverfew for humans with cancer. The parthenolide content of commercially available feverfew supplements varies substantially, by over 40-fold, despite labeling claims of “standardization”.”


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