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PEMF and Bone Lesions
Hi David,- My Google search brought me to your website. For “PEMF and bone lesions”. We have emailed a couple of times in the past. You are always so kind and helpful. 🙏🏼
Recently, my latest MRI test results were good and bad. The drug, Talvey (I was hospitalized to ramp up in August) is not working. I really wanted it to be my miracle.
The good news: I have a mass on my brain that radiation and spinal tap chemo have brought down by 75%. I still deal with intermittent double vision and a frozen chin/lower lip. Very frustrating.
The bad news: several long bones, sternum, and right hip have large, aggressively growing lesions. I’ve already had a rod inserted in my left leg at the end of February. That was done to prevent a fracture. The lesion at the time was 12 cm. Now the one on my right leg is 18 cm! The right arm is also serious.
Having more surgery is not my favourite option. So I’m wondering if I really applied the PEMF mat to my legs and arm for a couple of hours a day, could I shrink the lesions?
I have a PEMF mat and have used it regularly, mostly on my back. Strangely enough, I don’t have any MM in my spine. Related?
There is also “interventional radiology,” I found online. Is this an alternative?
How do MM people live with so many large lesions if treatment doesn’t work?
The combo my Oncology suggests next is XPD? I need to research this.
Any help you can offer I’d be most grateful for! Penelope
PEMF could be as effective as bone drugs?!
Hi Penelope-
I will excerpt your questions and answer each as best I can- I am sorry to read about your MM challenges.
1) Having more surgery is not my favourite option. So I’m wondering if I really applied the PEMF mat to my legs and arm for a couple of hours a day, could I shrink the lesions?
My understanding of PEMF is that it enhances bone mineral density and reduces inflammation. Please see the video and the research linked below. I have never read anything, any study about eliminating bone lesions in MM.
2) There is also “interventional radiology,” which I found online. Is this an alternative?
Local radiation can zap a specific bone lesion. Radiation can also damage nearby organs. Got to be careful.
3) How do MM people live with so many large lesions if treatment doesn’t work?
Bone involvement is a significant challenge with MM patients. Not a problem when lesions are small. If a lesion grows too large, it can cause bone damage. The two therapies I know of to manage bone involvement in MM are radiation and aggressive chemotherapy.
4) The combo my Oncology suggests next is XPD? I need to research this.
Do you mean “XPO” or Xpovio? This might be a systemic therapy to shrink or eliminate your bone lesions.
I hope this helps. Let me know if you have any questions.
Hang in there,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Pulsed Electromagnetic Field Stimulation of Bone Healing and Joint Preservation: Cellular Mechanisms of Skeletal Response
The US FDA has approved pulsed electromagnetic fields (PEMFs) as a safe and effective treatment for nonunions of bone. Despite its clinical use, the mechanisms of action of electromagnetic stimulation of the skeleton have been elusive.
Recently, cell membrane receptors have been identified as the site of action of PEMF and provide a mechanistic rationale for clinical use.
This review highlights key processes in cell responses to PEMF as follows:
- (1) signal transduction through A2A and A3 adenosine cell membrane receptors and
- (2) dose-response effects on the synthesis of structural and signaling extracellular matrix (ECM) components.
Through these actions, PEMF can increase the structural integrity of bone and cartilage ECM, enhancing repair, and alter the homeostatic balance of signaling cytokines, producing anti-inflammatory effects. PEMFs exert a proanabolic effect on the bone and cartilage matrix and a chondroprotective effect counteracting the catabolic effects of inflammation in the joint environment.
Understanding of PEMF membrane targets, and of the specific intracellular pathways involved, culminating in the synthesis of ECM proteins and reduction in inflammatory cytokines, should enhance confidence in the clinical use of PEMF and the identification of clinical conditions likely to be affected by PEMF exposure.
PEMF and bone lesions PEMF and bone lesions PEMF and bone lesions