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Plasma Cell Multiple Myeloma- A Bone Cancer? A Blood Cancer?

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Multiple myeloma is frequently identified because malignant plasma cell continue producing an antibody, which can be detected as a paraprotein.

If you are reading this page,  you may be wondering why multiple myeloma (MM) is sometimes called a blood cancer or a bone cancer and sometimes plasma cell myeloma (PCM). The info below may be more than you want to know about plasma myeloma but since you’re here…


Here we go…

Plasma is the “liquid” portion of the blood and is made mostly of water and some solutes. It makes up approximately 55% of whole blood volume. 

Platelets,  together with red blood cells and white blood cells, make up the hematocrit portion of the blood, approximately 45% of volume.

So plasma is the liquid component, while platlets are the “plugs” circulating in the blood and part of the solid portion of whole blood.

MM isn’t really a “bone cancer.” Yes, MM originates in your bones. But MM is really more specific than a bone cancer. MM isn’t even really a blood cancer either. As the links below discuss, blood is made up of

  • red blood cells, white blood cells and platelets (45% of the liquid in your veins)
  • plasma (55% of the liquid in your veins).

MM should really be called “plasma cell myeloma” because MM is a cancer of the plasma cells. MM happens when plasma cells reproduce uncontrollably.

Have you been diagnosed with MM? What stage? What symptoms are you experiencing? Bone pain? Anemia (low red blood cells…)? Kidney damage?

Bone health is fundemental to all MMers. Click the link below to access a Bone Health guide for FREE, no strings attached:

Multiple Myeloma Cancer Coaching Bone Health Guide

If you have been diagnosed with MM, and would like to learn more about evidence-based therapies that you incorporate into your daily life to enhance the efficacy of chemotherapy, protect your body from side effects, and support your health, please click the blue button below to watch a FREE 15 minute webinar:

Thank you,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.[1]

In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume),[2] and contains dissipated proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves..

The blood cells are mainly

Multiple myeloma

Multiple myeloma, also known as PCM, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.[5]..”

Plasma cell

Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies. They are transported by the blood plasma and the lymphatic system. Plasma cells originate in the bone marrow;..”

Role in disease

Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and PC  leukemia are malignant neoplasms (“cancer”) of the plasma cells.[11] Multiple myeloma is frequently identified because malignant plasma cells continue producing an antibody, which can be detected as a paraprotein.

Common variable immunodeficiency is thought to be due to a problem in the differentiation from lymphocytes to plasma cells. The result is a low serum antibody level and risk of infections.

Primary amyloidosis (AL) is caused by the deposition of excess immunoglobulin light chains which are secreted from plasma cells…”

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