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Polyphenols Gut Health and Myeloma
Looking for an evidence-based, non-toxic anti-MM twofer? According to the bottom two articles below, polyphenols enhance gut health while they fight multiple myeloma.
Because multiple myeloma is an incurable blood cancer, many MM patients look for therapies to manage their MM in addition to conventional therapies such as chemotherapy, radiation, and surgery.
Nutrition and nutritional supplementation are two of the most popular therapies to complement conventional therapies. Not only are some polyphenols cytotoxic to MM, but they have also been shown to enhance the gut microbiota. A diverse microbiome enhances immunity and helps cancer patients endure the rigors of remissions and relapses.
Microbiome 101: Learning about Gut Health for Myeloma Patients and Caregivers
I am a long-term MM survivor. I began supplementing with curcumin, resveratrol and green tea years ago because I came upon studies showing that these polyphenols were cytotoxic to MM. Recently, I have come upon studies that cite the importance of the gut microbiome to our immune system, as well as overall health.
Email me at David.PeopleBeatingCancer@gmail.com to learn more about both conventional and non-conventional MM therapies.
Thank you,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Targeting multiple myeloma with natural polyphenols
- Curcumin
- Apigenin
- Quercetin
- Genistein
- Epigallocatechin-3-gallate (green tea)
- Resveratrol
Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics
“Abstract
The present review summarizes the studies carried out on this topic in the last five years. According to the new definitions, among all the compounds included in the group of prebiotics, polyphenols are probably the most important secondary metabolites produced by the plant kingdom.
Many of these types of polyphenols have low bioavailability, therefore reaching the colon in unaltered form. Once in the colon, these compounds interact with the intestinal microbes bidirectionally by modulating them and, consequently, releasing metabolites.
Despite much research on various metabolites, little is known about the chemistry of the metabolic routes used by different bacteria species. In this context, this review aims to investigate the prebiotic effect of polyphenols in preclinical and clinical studies, highlighting that the consumption of polyphenols leads to an increase in beneficial bacteria, as well as an increase in the production of valuable metabolites.
In conclusion, there is much evidence in preclinical studies supporting the prebiotic effect of polyphenols, but further clinical studies are needed to investigate this effect in humans…
The effect of polyphenols on the intestinal microbiota is achieved by influencing the growth and metabolism of bacteria and by interfering with the cell function of the cell membrane. The majority of the polyphenols can hinder biofilm formation and significant effects via the hindering of bacterial quorum sensing…
Conclusions
This review concludes that, through recent studies and their integration in the category of prebiotics since 2016, polyphenols can be used to modulate the intestinal microbiota, a role added to their main properties, which are antioxidant and anti-inflammatory.
Numerous studies, both in vitro and in vivo, show the interrelationship between polyphenols and gut microbiota. These compounds, not only by their structure but also by the resulting metabolites, are a substrate for probiotics, resulting in the growth of beneficial bacteria and the reduction of pathogenic bacteria, thereby maintaining host intestinal homeostasis.
However, it is necessary to develop more studies focusing on the polyphenols’ effects in clinical trials, specifically on their metabolic pathways, the evidence observed mainly in the animal in vitro studies. Using advanced techniques such as omics technologies: metabolomics, genomics, metagenomics, trans-genomics, or proteomics; a better understanding of the polyphenols’ action in the living organisms and their consequent metabolites could be provided. Additionally, their prebiotic effect could be clearly defined and used therapeutically.
In conclusion, by summarizing the latest studies that highlight the prebiotic role of the polyphenols, they have the ability to influence both the modulation of the gut microbiota and the host’s general health through their beneficial effects deriving from different mechanisms and impacting multiple organs and systems.”
polyphenols gut health multiple myeloma Polyphenols gut health multiple myeloma