“These results showed that Cannabidiol by itself or in synergy with BORT (velcade) strongly inhibited growth, arrested cell cycle progression and induced Multiple Myeloma cell death
Hi Dave, I am 39 years old. I was diagnosed in 2009 with a plasmacytoma in my C2 vertibrae which we treated with Radiation and Velcade. I was clear for 10 Years. I was then diagnosed with multiple myeloma (MM) in January this year.
I then started Velcade and Indoxane Protocol for 4 cycles. Did my bone marrow test last week and my marrow is clear of MM cells.
The Oncologists are saying I am a prime candidate for a Bone Marrow transplant which they would like to do asap.
What is your opinion or advice you can offer for me as this is a big decision?
I have already started a strict nutrition plan for life. I am fit and healthy.
I am also interested in trying alternative treatments like CBD and THC oils.
Your advice would be greatly appreciated!
Warm Regards, Daniel
I will clarify several assumptions that I am making based on your email to me. Let me know if I misunderstand something.
- You are 39 today but you were 29 when you were first diagnosed?
- By using the word “plasmacytoma” I am assuming that you were first diagnosied with a “single bone plasmacytoma (SBP) with is pre-myeloma, not frank or full-blown MM. In effect, as of last January, you are a newly diagnosed MM patient. If you are curious about this distinction I would have to look at your blood diagnostic work-up to determine things like your m-spike, total protein, etc.
- My interpretation of the word “indoxane” is “exdoxan” which is a brand name for cytoxan aka cyclophosphamide.
- If by saying that “my marrow is clear of MM cells“ I am thinking that you have reached either 1) complete remission (CR) 2) stringent complete remission (sCR) or 3) MDR, minimal residual disease- negative. All three responses to your chemo of velcade and cytoxan are an excellent response. Your level of response is important for your next therapy steps. See below.
As to your question “What is your opinion or advice you can offer for me as this is a big decision?”
- At 39, you are extremely young as MMers go. I say this because conventional MM oncology thinks in terms of 5-10 year survival for the majority of average MMers. My guess is that you are thinking about 40-50 year therapy plans.
- By achieving a good response/remission to velcade/cytoxan (VGPR, CR, sCR or MRD negative) studies show that an autologous stem cell transplant either immediately or years from now has no effect on your long-term or overall survival (length of life).
- My point with the above 1 and 2 is to say that an ASCT is high dose, aggressive, very toxic therapy. Yes, an ASCT is great for producing a remission in the average MM patient. Unfortunately, an ASCT achieves a remission by giving the MM patient a LOT of toxic chemotherapy. You, at 39, are not the average MMer who is 67, on average.
- In my opinion, the goal of the young MM patient is to manage his/her MM, with as little toxicity, for was long as he/she can. Undergoing so much toxicity now will not only be hard on your body, potentially causing short, long-term and late stage side effects, it will push you toward MDR or multi-drug resistence. MDR is the reason why all MMers relapse and die. Chemotherapy eventually stops working.
- Lastly, according to studies as well as my personal experience, evidence-based integrative therapies such as CBD/THC can enhance the efficacy of chemotherapy while reducing its toxicity. CBD/THC may be cytotoxic to MM on its own. I will link study below and I will link the MM CC cannabis guide as well. There are many evidence-based non-toxic therapies shown to be cytotoxic to MM.
The above is a long, complicated answer to your question. Let me know if you have any questions.
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
“…Meta-regression analyses failed to demonstrate any association between CR or (CR or VGPR) with either overall survival or progression-free survival both in patients receiving autologous stem cell transplant [ASCT] and in non-ASCT patients.””
“These results showed that Cannabidiol by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells. These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM.”