Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission
Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Probiotics’ Correlated w/ Myeloma
According to the research below, some probiotics are positively associated with myeloma and some probiotics are negatively associated with myeloma. Further, gut microbiota diversity, composition, and abundance can enhance overall survival in myeloma.
Microbiome 101: Learning about Gut Health for Myeloma Patients and Caregivers
Which gut microbiota are associated with longer overall survival in multiple myeloma?
Several studies have suggested that specific gut microbiota compositions are associated with longer overall survival in multiple myeloma (MM). While research in this area is still evolving, some key findings include:
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Higher abundance of beneficial bacteria
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Faecalibacterium prausnitzii: Known for its anti-inflammatory properties and production of butyrate, which helps regulate immune responses.
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Bifidobacterium: Associated with improved gut barrier function and immune modulation.
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Akkermansia muciniphila: Linked to better treatment response, potentially through enhancing immune checkpoint inhibitor efficacy.
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Lower abundance of pro-inflammatory bacteria
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Escherichia coli and Enterobacteriaceae: These bacteria can promote systemic inflammation, which is often associated with disease progression.
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Clostridium spp.: Certain species have been linked to immune suppression and poor outcomes.
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Diversity and Composition
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Higher microbial diversity has been correlated with better responses to therapy and improved overall survival in MM.
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A balance between Firmicutes and Bacteroidetes appears to be important, with excessive dysbiosis (imbalance) potentially contributing to MM progression.
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Potential Mechanisms
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Enhanced immune function: A healthy gut microbiome can modulate T-cell responses and promote anti-tumor immunity.
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Reduced inflammation: Beneficial bacteria help maintain gut barrier integrity and lower systemic inflammation, which may slow disease progression.
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Improved response to therapy: Certain microbiota profiles have been linked to better responses to immunomodulatory drugs (IMiDs) and autologous stem cell transplantation (ASCT).
Enhancing the gut microbiome of MM patients puts even more pressure on the idea of NDMM patients “prehabilitating” or getting in shape for managing their MM. But whether you are a NDMM patient who has not begun therapy or you are well-into your therapy plan, consider focusing on your diet and gut health.
I am a long-term MM survivor. I wish I knew then what I know now.
Email me at David.PeopleBeatingCancer@gmail.com with questions about both conventional and non-conventional MM therapies.
Good luck,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Exploring the causal relationship between gut microbiota and multiple myeloma risk based on Mendelian randomization and biological annotation
Introduction
The microbial genome-wide association studies (mbGWAS) have highlighted significant host-microbiome interactions based on microbiome heritability. However, establishing causal relationships between particular microbiota and multiple myeloma (MM) remains challenging due to limited sample sizes…
Results
We discovered that 10 gut microbial taxa were causally related to MM risk. Among them,
- family Acidaminococcaceae,
- Bacteroidales family S24-7,
- family Porphyromonadaceae,
- genus Eubacterium ruminantium group,
- genus Parabacteroides, and
- genus Turicibacter
were positively correlated with MM. Conversely, class Verrucomicrobia, family Verrucomicrobiaceae, genus Akkermansia, and order Verrucomicrobiales were negatively correlated with MM…
Discussion
Overall, this study provides evidence supporting a potential causal relationship between gut microbiota and MM risk, while also revealing novel host-microbiome shared genes relevant to MM immunoregulation and clinical prognosis…
The human intestine hosts a diverse and intricate microbial community known as gut microbiota, which derives from various sources, including dietary intake and probiotic supplements. These microbiotas are essential for maintaining mucosal barrier integrity and offering numerous other health benefits (Badgeley et al., 2021).
Currently, gut microbiota is recognized as both a contributor to and a safeguard against various human diseases, including its intricate involvement in the pathogenesis of MM (Park et al., 2022). Conversely, cancer can influence the host’s gut microbiota, potentially leading to microbiota disruption and tumor progression (Yonekura et al., 2022)…
Despite the challenges of obtaining real-time microbiome data in clinical practice, retrospective studies have started illuminating the relationship between changes in particular microbial characteristic and MM (Zhang et al., 2022). Due to confounding factors such as lifestyle, environment, host gene mutations, and potential reverse causality, the precise association between genes in MM patients and gut microbiota remains underexplored…
According to the above results, we hypothesize that hub genes exert a substantial influence on the progression of MM. Thus, we utilized the Kaplan-Meier plotter to investigate the association between the expression profiles of hub genes and the overall survival (OS) rates in individuals with MM. We found that higher expression levels of six genes were associated with improved OS in MM patients, whereas high expression of RAB5B was linked to poorer OS (Figure 6)…
In summary, our study has identified several gut microbiota that may possess the potential to impact the risk of MM. We also identified novel host-microbiome shared genes linked to immune regulation and clinical prognosis in MM.
These results could hold considerable clinical implications for MM prevention and therapy. Nevertheless, further investigations are needed to elucidate the specific mechanisms that could serve as potential intervention targets for MM…”
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