Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Four years of conventional multiple myeloma (MM) therapies of surgery, radiation and chemotherapy left me with a host of short, long-term and late stage side effects and “there is nothing more we can do for you.”
Simply put, there are many MM patients/survivors who do not benefit from chemotherapy and radiation. Chemotherapy and radiation can cause all manner of health problems and may not add time to your life. Much less cure your cancer.
Oncology doesn’t like to talk about it but it’s true.
Hi. My name is David Emerson. I am a long-term cancer survivor (multiple myeloma) who calls himself a cancer coach. WTF??? A cancer coach? Let me explain what I mean.
Surviving an incurable blood cancer like mine, multiple myeloma, involves managing the cancer itself with chemotherapy and radiation, plus managing the short, long-term and late stage side effects that result from that chemotherapy and radiation.
Please don’t misunderstand me. There are times when conventional therapies such as
are necessary. The trick is to know when and how much therapy is needed.
The other trick involved in managing cancer is what non-toxic therapies are helpful to the cancer patient/survivor. I have managed both- my cancer and my side effects- since my original diagnosis in early 1994. My research and experience can be extremely helpful for newly diagnosed MM patients and survivors struggling with multiple myeloma and its many symptoms and side effects.
While the diet of cancer patients is central to managing their cancer, I believe that nutrition, food, isn’t enough. I add to my nutrition with nutritional supplementation. I am writing about quercetin in the blog.
Not only do I suffer from a risk of relapse from my original cancer, multiple myeloma, I suffer from the real risk of a treatment-related secondary cancer. A possible side effect of my original chemo and radiation in ’94,’95,’96.
In addition, high-dose chemotherapy caused atrial fibrillation in late 2010. I have lived with chemotherapy-induced Cardiomyopathy (CIC) since 2010.
In addition, I developed a common side effect of high dose chemotherapy called chemobrain. Chemotherapy-induce cerebral dysfunction is a problem for lots of cancer survivors.
In addition, my cancer, multiple myeloma, is both a cancer of the bone marrow as well as a sort of bone cancer. In short, MM causes the survivors bones to weaken and possibly break.
When I talk about managing my cancer and side effects, I’m talking about a possible relapse, secondary cancer, a heart attack, brain damage and/or bone damage. A
I eat lots of fruits and veggies daily. I also supplement with quercetin. I highly recommend this nutritional supplement.
“Quercetin inhibits proliferation of MM cells by inducing apoptosis and cell cycle arrest in the G0/G1 or G2 phase through downregulating c-myc and cyclinD1 and upregulating p21 .Quercetin also displays synergistic inhibition effect with dexamethasone.Thus, quercetin combination with dexamethasone therapy may be an effective option for MM patients…”
“Cardiovascular disease is a major cause of death worldwide despite the majority of its risk factors being preventable and treatable. The results of numerous epidemiological studies suggest that a diet rich in fruits and vegetables affords protection against CVD, and this may be attributed, in part, to the flavonoid quercetin…
Several studies have, however, shown that quercetin can reduce blood pressure in hypertensive patients. The exact mechanisms are yet to be elucidated…”
“Conclusions- The results of the meta‐analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day. Further studies are necessary to investigate the clinical relevance of these results and the possibility of quercetin application as an add‐on to antihypertensive therapy.
“Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba.
Appositeness of quercetin in reducing risks of neurodegenerative disorders, cancer, cardiovascular diseases, allergic disorders, thrombosis, atherosclerosis, hypertension, and arrhythmia, to name a few, is attributed to its highly pronounced antioxidant and anti-inflammatory properties.
Neurodegeneration, characterized by progressive deterioration of the structure and function of neurons, is crucially accompanied by severe cognitive deficits.
Aging is the major risk factor for neurodegenerative disorders in Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) being coequal high hands…”
“The flavonoid quercetin decreases the differentiation of osteoclast progenitor cells and inhibits the activity of mature osteoclasts (3–5). Quercetin might act together with the alkaline-forming properties of fruit to inhibit osteoclasts and enhance bone mineral density…”
“Among patients with myelodysplastic syndrome (MDS), quercetin may induce autophagy in myelodysplastic bone marrow, according to a mouse model analysis published in Environmental Toxicity.
MDS represents a set of clonal hematopoietic disorders that may lead to bone marrow failure, refractory peripheral cytopenia, or progression to acute myeloid leukemia.
Most cases of MDS are asymptomatic, though anemia, neutropenia, and thrombocytopenia can be present. Previous studies suggest that the PI3K/Akt/mTOR pathway plays a crucial role in managing autophagy. In addition, the pathway is frequently overactive in malignancies.
Quercetin, an isoflavanoid commonly found in fruits and vegetables, which appears to have antioxidant properties, may be useful for stimulating autophagy…
There was also evidence that quercetin triggers an upregulation of basal autophagocytosis, possible reversal of oxidative damage, and functionality of the mitochondria and lysosomes.
“[T]he myelodysplastic bone marrow experiences severe hematopoietic devastations during the course of the disease and involves a paradox in bone marrow and peripheral blood manifestations,” the authors wrote. “Lastly, it can be stated that the therapeutic regimen with dietary isoflavanoid quercetin is a curative measure [that] could restore protective autophagocytosis in myelodysplastic cases and could partly revert back the hematologic catastrophic condition.”
“Quercetin‘s antioxidant and anti-inflammatory effects have made it an increasingly popular supplement among those looking to boost immune, cardiovascular, and metabolic health. Over the past two decades, several preclinical reports on the antineoplastic effects of quercetin have been published…
Quercetin is a plant flavonol from the flavonoid group of polyphenols. Found in many foods and teas, the highest concentrations are in capers, cilantro, red onion, kale, broccoli, apples, and certain berries (eg, chokeberry, cranberry, lingonberry). It is one of the most common flavonoids in the diet, with US adults estimated to consume around 12 mg of quercetin in their diet every day…
Dozens of animal and in vitro studies suggest that quercetin promotes apoptosis, stimulates autophagy, and induces cell-cycle arrest at various phases in cancer cells. These studies also show that quercetin can inhibit tumor angiogenesis and metastasis by targeting the vascular endothelial growth factor receptor 2–dependent pathway and inhibiting the epithelial-to-mesenchymal transition process, among other mechanisms…
“PURPOSE: Although radiation is one of the basic methods commonly used in cancer treatment, it inevitably enters the field of treatment in healthy tissues and is adversely affected by the acute and chronic side effects of radiation. This study evaluated the possible protective effects of quercetin, an antioxidant agent, against liver and kidney damage in rats exposed to a whole-body single dose of radiation (10 Gy of gamma-ray)…
CONCLUSIONS: With the results obtained from the study; Quercetin is thought to have a protective potential against radiation-induced liver and kidney damage due to its radioprotective effect…”