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PeopleBeatingCancer

Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

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Quercetin- Multiple Myeloma, Heart, Brain, Bone Health

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“Quercetin‘s antioxidant and anti-inflammatory effects have made it an increasingly popular supplement among those looking to boost immune, cardiovascular, and metabolic health.”

Four years of conventional multiple myeloma (MM) therapies of surgery, radiation and chemotherapy left me with a host of short, long-term and late stage side effects and “there is nothing more we can do for you.”

Simply put, there are many MM patients/survivors who do not benefit from chemotherapy and radiation. Chemotherapy and radiation can cause all manner of health problems and may not add time to your life. Much less cure your cancer.

Oncology doesn’t like to talk about it but it’s true.

Hi. My name is David Emerson. I am a long-term cancer survivor (multiple myeloma) who calls himself a cancer coach. WTF??? A cancer coach? Let me explain what I mean.

Surviving an incurable blood cancer like mine, multiple myeloma, involves managing the cancer itself with chemotherapy and radiation, plus managing the short, long-term and late stage side effects that result from that chemotherapy and radiation.

Please don’t misunderstand me. There are times when conventional therapies such as

  • surgery,
  • radiation and
  • chemotherapy,

are necessary. The trick is to know when and how much therapy is needed.

The other trick involved in managing cancer is what non-toxic therapies are helpful to the cancer patient/survivor. I have managed both- my cancer and my side effects- since my original diagnosis in early 1994. My research and experience can be extremely helpful for newly diagnosed MM patients and survivors struggling with multiple myeloma and its many symptoms and side effects.

While the diet of cancer patients is central to managing their cancer, I believe that nutrition, food, isn’t enough. I add to my nutrition with nutritional supplementation. I am writing about quercetin in the blog.

Not only do I suffer from a risk of relapse from my original cancer, multiple myeloma, I suffer from the real risk of a treatment-related secondary cancer. A possible side effect of my original chemo and radiation in ’94,’95,’96.

In addition, high-dose chemotherapy caused atrial fibrillation in late 2010. I have lived with chemotherapy-induced Cardiomyopathy (CIC) since 2010.

In addition, I developed a common side effect of high dose chemotherapy called chemobrain. Chemotherapy-induce cerebral dysfunction is a problem for lots of cancer survivors.

In addition, my cancer, multiple myeloma, is both a cancer of the bone marrow as well as a sort of bone cancer. In short, MM causes the survivors bones to weaken and possibly break.

When I talk about managing my cancer and side effects, I’m talking about a possible relapse, secondary cancer, a heart attack, brain damage and/or bone damage. A

I eat lots of fruits and veggies daily. I also supplement with quercetin. I highly recommend this nutritional supplement.

I supplement with Life Extension Foundation’s Optimized Resveratrol. This supplement includes 150 mg of quercetin.

Thanks,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Quercetin Displays Anti-Myeloma Activity and Synergistic Effect with Dexamethasone in Vitro and In Vivo Xenograft Models

“Quercetin inhibits proliferation of MM cells by inducing apoptosis and cell cycle arrest in the G0/G1 or G2 phase through downregulating c-myc and cyclinD1 and upregulating p21 .Quercetin also displays synergistic inhibition effect with dexamethasone.Thus, quercetin combination with dexamethasone therapy may be an effective option for MM patients…”

The Efficacy of Quercetin in Cardiovascular Health

“Cardiovascular disease is a major cause of death worldwide despite the majority of its risk factors being preventable and treatable. The results of numerous epidemiological studies suggest that a diet rich in fruits and vegetables affords protection against CVD, and this may be attributed, in part, to the flavonoid quercetin…

Several studies have, however, shown that quercetin can reduce blood pressure in hypertensive patients. The exact mechanisms are yet to be elucidated…”

Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

“Conclusions- The results of the meta‐analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day. Further studies are necessary to investigate the clinical relevance of these results and the possibility of quercetin application as an add‐on to antihypertensive therapy.

Role of Quercetin Benefits in Neurodegeneration

“Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba.

Appositeness of quercetin in reducing risks of neurodegenerative disorders, cancer, cardiovascular diseases, allergic disorders, thrombosis, atherosclerosis, hypertension, and arrhythmia, to name a few, is attributed to its highly pronounced antioxidant and anti-inflammatory properties.

Neurodegeneration, characterized by progressive deterioration of the structure and function of neurons, is crucially accompanied by severe cognitive deficits.

Aging is the major risk factor for neurodegenerative disorders in Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) being coequal high hands…”

Quercetin, fruit consumption, and bone mineral density

“The flavonoid quercetin decreases the differentiation of osteoclast progenitor cells and inhibits the activity of mature osteoclasts (3–5). Quercetin might act together with the alkaline-forming properties of fruit to inhibit osteoclasts and enhance bone mineral density…”

Quercetin May Induce Autophagy in Myelodysplastic Bone Marrow, Mouse Model Suggests

“Among patients with myelodysplastic syndrome (MDS), quercetin may induce autophagy in myelodysplastic bone marrow, according to a mouse model analysis published in Environmental Toxicity.

MDS represents a set of clonal hematopoietic disorders that may lead to bone marrow failure, refractory peripheral cytopenia, or progression to acute myeloid leukemia.

Most cases of MDS are asymptomatic, though anemia, neutropenia, and thrombocytopenia can be present. Previous studies suggest that the PI3K/Akt/mTOR pathway plays a crucial role in managing autophagy. In addition, the pathway is frequently overactive in malignancies.

Quercetin, an isoflavanoid commonly found in fruits and vegetables, which appears to have antioxidant properties, may be useful for stimulating autophagy…

There was also evidence that quercetin triggers an upregulation of basal autophagocytosis, possible reversal of oxidative damage, and functionality of the mitochondria and lysosomes.

“[T]he myelodysplastic bone marrow experiences severe hematopoietic devastations during the course of the disease and involves a paradox in bone marrow and peripheral blood manifestations,” the authors wrote. “Lastly, it can be stated that the therapeutic regimen with dietary isoflavanoid quercetin is a curative measure [that] could restore protective autophagocytosis in myelodysplastic cases and could partly revert back the hematologic catastrophic condition.”

Any Merit to Quercetin’s Anticancer Claims?

“Quercetin‘s antioxidant and anti-inflammatory effects have made it an increasingly popular supplement among those looking to boost immune, cardiovascular, and metabolic health. Over the past two decades, several preclinical reports on the antineoplastic effects of quercetin have been published…

Quercetin is a plant flavonol from the flavonoid group of polyphenols. Found in many foods and teas, the highest concentrations are in capers, cilantro, red onion, kale, broccoli, apples, and certain berries (eg, chokeberry, cranberry, lingonberry). It is one of the most common flavonoids in the diet, with US adults estimated to consume around 12 mg of quercetin in their diet every day…

Dozens of animal and in vitro studies suggest that quercetin promotes apoptosis, stimulates autophagy, and induces cell-cycle arrest at various phases in cancer cells. These studies also show that quercetin can inhibit tumor angiogenesis and metastasis by targeting the vascular endothelial growth factor receptor 2–dependent pathway and inhibiting the epithelial-to-mesenchymal transition process, among other mechanisms…

Hepatotoxicity and renal toxicity induced by radiation and the protective effect of quercetin in male albino rats

“PURPOSE: Although radiation is one of the basic methods commonly used in cancer treatment, it inevitably enters the field of treatment in healthy tissues and is adversely affected by the acute and chronic side effects of radiation. This study evaluated the possible protective effects of quercetin, an antioxidant agent, against liver and kidney damage in rats exposed to a whole-body single dose of radiation (10 Gy of gamma-ray)…

CONCLUSIONS: With the results obtained from the study; Quercetin is thought to have a protective potential against radiation-induced liver and kidney damage due to its radioprotective effect…”

 

 

Leave a Comment:

12 comments
Amber Peña says 3 weeks ago

Hi Mr Emerson,

My mom was recently diagnosed with MM and has decided to stop chemo after only one week. I’m looking for anything that could help her despite her decision to refuse the treatment. She has mentioned quercitin. Could you suggest a kickstart plan in this type of situation. I appreciate any advice. Thanks so much

Reply
Amber Peña says 3 weeks ago

Hi Mr Emerson,

My mom was recently diagnosed with MM and has decided to stop chemo after only one week. I’m looking for anything that could help her despite her decision to refuse the treatment. She has mentioned quercitin. Could you suggest a kickstart plan in this type of situation. I appreciate any advice.

Reply
Jim Boersma says a few months ago

Hello David Emerson; I am a newly diagnosed MM patient…(Diagnosed at Mayo Clinic back in March 2023) I am 71 years old in good physical condition but I can tell the side effects from all the treatments is taking a toll on me. I have undergone 8 months of chemo (Velcade every week), 12 mg of dexamethasone once a month. Also take 5 mg of Revlimid since July of 2023. Now I am scheduled to go through extensive testing next week at Mayo Clinic and yes they are talking about me going through stem cell transplantation.. At diagnosis back in March there were no active Lytic lesions in my skeleton. It will be interesting to see if any new lesions show up now next week when they do another skeletal survey. They want to extract my stem cells now in November and can bank them for 10 years until which time it may be necessary to do a stem cell transplant. I know two of my friends with MM that have gone through stem cell transplant…one of which did not stay in remission. My other MM friend had two transplants and has been in remission for 8 years. So I am not convinced that a stem cell transplant is the answer but I know my oncologist is trying to get me to go ahead with the transplant. If you have any sage advice for me, I am all ears as to what questions to ask Mayo next week when I’m going through all the testing, labs etc. I’ve been very impressed with all the information your webpage offers us MM survivors. Thankfully submitted! Jim Boersma Olivia, Minnesota

Reply
George Bernal says 6 months ago

Hi David , my white blood cells are 2.3. Absolute Neutrophils 1.0. Am getting infections due to lowered immunity. What can I take to bolster up my immune system ?

Reply
Emily says a couple of years ago

How much quercetin should a person with Multiple Myeloma take per day?

Reply
    David Emerson says a couple of years ago

    Hi Emily-

    Unfortunately there is no dose given in the study linked in that blog post. Most studies I read taking about anti-mm supplementation talk about “time and dose dependent manner” meaning the more, the longer, the better.

    When I supplement (curcumin, quercetin, omega-3, etc.) I take the dose recommended on the label.

    David Emerson

    Reply
    Sally Volpe says a few months ago

    Can I take Quercetin when I am getting Velcade? I know no green tea or vit c but Quercetin? Thank you

    Reply
      David Emerson says a few months ago

      Hi Sally-

      According to the research lined below, flavonoids (quercetin) reduces the efficacy of velcade aka bortezomib for MM treatment.

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292595/

      Consider supplementing and stopping 48 hours before your injection and then beginning again 48 hours after.

      Good luck,

      David Emerson

      Reply
robin bloom says a couple of years ago

one more thought . is there a possibility of stopping velcaid and testing just life extension blend of resveratrol and quercetin to see if this could reverse her kappa rise. and also add the sulforaphane and garlic /allicin supplement as hdac inhibitors? thanks for considering this less toxic approach ,as velcaid has caused some nerve damage and hand tremor for Billie, so not happy about resuming it just yet. her freechain ratio is less than it was in jan. 2020 when her pet/ct scan was still free of new lesions ,so we have more time i feel to test some all natural approaches. thanks again for listening.

Reply
    David Emerson says a couple of years ago

    Hi Robin-

    I will reply to this post as well when I email you directly. Hang in there.

    David Emerson

    Reply
robin bloom says a couple of years ago

i have just read quercetin can block velcaids effectiveness ,much like vit. c and green tea . is this true from info. that you have researched. i have read quercetin is a hdac inhibitor,which helps kill m.myeloma cells. there is a m.myeloma drug called panbinostat that acts as a hdac inhibitor ,and works synergistically with velcaid to make velcaid work again after your m.myeloma clone cells have become resistent or partially resistent to velcaid, which is my wifes situation now it appears. we’ll either try just the quercetin ,or maybe the velcaid and the panabinostat to beat back rising kappas as Billie has taken a 4 month break from velcaid to allow her immune system to form antibodies for covid after taking the 2 moderna vaccines. her pet/ct scan last month was free of new lesions and her b.m. biopsy showed 8% clone cells. but still the freechain ratio has skyrocketed from 25 to 150 now after the 4 month break. not sure what we should do now? either just add quercetin 500 mg garlic /allicin supplements and sulforophane and no velcaid ,or do velcaid and other natural sources of hdac inhibitors like garlic and sulforophane supplements ,and perhaps the panbinostat to sensitize the clonal cells to velcaid again? your thoughts? if you have some would be much appreciated. you know i respect your opinion very much! sincerely Robin

Reply
    David Emerson says a couple of years ago

    Hi Robin-

    I will reply to this question directly via your email address so that I can include the supplement, integrative and bone health MM CC course guides.

    David Emerson

    Reply
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