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Radiation-induced cystitis treatments
Radiation-induced cystitis (RC) is high on my list of reasons for my mantra “I wish I knew then what I know now.”
I was diagnosed with a blood cancer called multiple myeloma in early 1994. My cancer produced a number of lytic lesions. Radiation therapy has been shown to be effective at zapping lesions produced by MM.
Unfortunately, radiation can cause collateral damage to surrounding tissues/organs. In my case I developed radiation-induced cystitis. Based on the article linked below, I sustained a mild case however.
But I wish I knew about hyperbaric oxygen therapy as a non-toxic therapy to heal my mild case of radiation-induced cystitis.
Healing Radiation Injury with Hyperbaric Oxygen Therapy
While HBO therapy may fully heal radiation-induced cystitis, I have found other therapies that seem to help. These are:
I also what to point out that radiation can cause damage of many different types for cancer patients who use this form of therapy. As often as not, HBOT can reduce if no eliminate symptoms.
Are you a MM survivor? Has radiation therapy caused damage of any sort? Email me at David.PeopleBeatingCancer@gmail.com with questions about symptoms and possible therapies.
Good luck,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): long-term follow-up of a randomised controlled, phase 2–3 trial
“Background
Chronic radiation-induced cystitis is a common and often debilitating complication of radiotherapy for pelvic cancers, affecting approximately 5–10% of patients.
Symptoms such as:
- haematuria,
- urinary urgency,
- frequency,
- and dysuria
significantly affect quality of life. Although hyperbaric oxygen (HBO2) alleviates symptoms, evidence regarding its long-term benefits is limited. This study reports on the 5-year follow-up of the RICH-ART trial, evaluating whether the therapeutic effects of HBO2 on chronic radiation-induced cystitis are sustained over a longer follow-up period…
Interpretation
Our findings provide evidence for the long-term effects of HBO2 in the treatment of chronic radiation-induced cystitis. Sustained symptom relief over 5 years supports its potential as a key therapeutic option for managing chronic radiation-induced adverse effects…
Radiotherapy for cancer can cause both acute and delayed adverse effects.1Acute radiation-induced adverse effects manifest within weeks or months of exposure and often resolve spontaneously.1,2 Adverse effects that develop or persist 6 months post radiotherapy are often referred to as late or chronic.1, 2, 3
They usually remain stable or worsen over 4–10 years of follow-up.4, 5, 6, 7 Chronic radiation-induced cystitis affects 5–10% of patients treated for prostate, rectal, or gynaecological cancers.3, 4, 5, 6 It presents with symptoms such as pain, increased urinary frequency, urgency, incontinence, and dysuria, leading to significant impairment in quality of life, with some patients developing severe complications such as gross haematuria…
Chronic radiation-induced cystitis is driven by hypoxia, fibrosis, and vascular damage caused by radiation.2,3 The pathogenesis begins with mucosal destruction, leading to ulcers, telangiectasia, and haematuria, as the bladder environment becomes hypovascular and hypocellular.3,11
Vascular injury, including endothelial damage and disrupted angiogenesis, further exacerbates these effects, contributing to fibrosis and structural disorganisation of the bladder.3,12 Additionally, neurogenic dysfunction likely plays a role in pain and impaired bladder control, highlighting the multifaceted nature of this condition.12
The severity of chronic radiation-induced cystitis correlates with radiation dose, fraction size, and bladder volume exposed, with some cases resulting in life-threatening haemorrhage due to endarteritis obliterans and bladder wall fibrosis.3..
Discussion
This 5-year follow-up of the RICH-ART trial demonstrated that the improvement in patient-reported symptoms of chronic RC observed after 30–40 HBO2 sessions persists over time..”
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