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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Radiation-induced Injury- Fibrosis
About a third of myeloma patients undergo radiation therapy. The challenge to these patients is radiation-induced injury- fibrosis. The solution? Therapies to either prevent radiation fibrosis or therapies that can heal radiation fibrosis.
What is radiation-induced injury? What is fibrosis? The video linked below does a good job of explaining the basic problem.
What Is Radiation-Induced Fibrosis?
I underwent radiation therapy three times to manage lytic lesions caused by my MM. The side effects caused by radiation are illustrative of how radiation can scar organs in the patient’s body.
For the record, I have to admit that local radiation did a great job of alleviating my bone pain.
- Treatment-induced Nerve Damage-CIPN and RILP
- Treatment-induced Hemorrhagic Cystitis-Irritable bladder
- Therapy-induced Dysphagia-Difficulty Swallowing
- Therapy-induced Xerostomia- Dry Mouth
Radiation therapy to my fifth cervical vertebra (lower neck) caused long-term problems with my neck-swallowing, talking, etc. Radiation therapy to my sacrum (tailbone) caused long-term problems to all nerves extending from my tailbone and to the organs in the path of the radiation (bladder, intestines, etc.)
Radiation will cause damage to the patient’s surrounding tissue and organs. If you are going to have radiation therapy, please read the study below.
If you have already undergone radiation therapy, the only therapy I know shown to heal radiation damage is hyperbaric oxygen therapy (HBOT).
Email me at David.PeopleBeatingCancer@gmail.com for more information about managing MM with both conventional and non-conventional therapies.
Hang in there,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies
This review systematically examines three fundamental regulatory mechanisms through which gut microbiota and its metabolites mitigate radiation-induced injury:
- modulation of intestinal epithelial cell regeneration and tumor cell apoptosis via Wnt/β-catenin and PI3K/AKT/mTOR pathways;
- immunomodulation via Toll-like receptor activation and NF-κB signaling;
- oxidative stress management via Nrf2 signaling.
We also evaluate various microbiota-targeted interventions, ranging from probiotics and prebiotics to fecal microbiota transplantation and emerging engineered microbial therapies, highlighting their potential in clinical radiotherapy…
Microbiota-targeted interventions for radiation injury management
Conventional approaches to treating radiation-induced injury, including glucocorticoids, free radical scavengers and antibiotics, are often limited by adverse effects such as immunosuppression, single-target mechanism, adverse effects, metabolic dysregulation.Citation51
Microbiota-based therapeutic strategies offer distinct advantages over conventional treatments for radiation-induced injury:
- (1) Multimodal Mechanisms:
- (2) Temporal Flexibility:
- (3) Reduced Toxicity: As naturally occurring commensal organisms, gut microbiota mediates biological regulation without introducing the toxic side effects associated with traditional drugs; and
- (4) Polypharmacological Effects: Unlike single-target therapies, microbiota-based approaches simultaneously address multiple pathological processes, including immunomodulation, epithelial barrier repair, and stem cell maintenance, resulting in more holistic therapeutic outcomes.Citation52
Prebiotic supplementation strategies
Our research has demonstrated that prebiotics, exemplified by dietary fiber, and their subsequent breakdown by gut microbiota into a range of micro- and macro-nutrients, including polyphenols and oligofructose (FOS), can regulate the composition of gut microbiota through various pathways, thereby influencing human health.Citation53,Citation54 Research on their application in radiotherapy has demonstrated that prebiotics can effectively alleviate symptoms such as gut dysbiosis and modulate inflammatory factors in patients following radiotherapy.Citation55…
Probiotic-based radioprotection
Probiotics are defined as live microorganisms that confer benefits to the host, primarily by improving the intestinal microbiome and enhancing immune function.Citation62 The most studied genera, Akkermansia and Lactobacillus, along with postbiotic, were primarily discussed…
- Lactobacillus rhamnosus GG
- Akkermansia muciniphila
- Postbiotic and microbial metabolite approaches
Microbial ecosystem transplantation
Emerging adjunctive therapies: phage, nutritional, and engineered microbial approaches
Additionally, emerging microbial therapies like phage therapy and nutritional intervention also show promise in enhancing microbiota-targeted radioprotective effects and treatment efficacy.
radiation-induced injury fibrosis radiation-induced injury fibrosis radiation-induced injury fibrosis