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Radioprotective Effect of Metformin Melatonin Resveratrol
What is the radioprotective effect of metformin melatonin resveratrol? And why do you need them? According to the three studies linked below, all three non-conventional therapies can protect cancer patients from radiation damage.
My blood cancer, multiple myeloma, led to a common symptom called “bone involvement.” Bone involvement simply means that my MM formed lytic lesions in my bone marrow and not other MM common symptoms such as kidney damage or anemia.
The good news is that local radiation is an effective therapy for MM patients who have lytic lesions. The bad news is that too much radiation can cause serious damage to the human body.
The radiation oncologist in the video below talks about radiation damage in the typical way that oncology talks about common side effects of all conventional therapies basically underplaying the severity and possibility of therapy-induced side effects.
My lesions as well as many MM lesions, are near the patient’s spine. Radiation to the spine can cause serious side effects.
Another complication of conventional oncology and their therapies, is that conventional oncology learns about and prescribes only FDA approved therapies. This is to be expected because the FDA manages health in the United States.
The challenge to MM patients is that the radioprotective effect of metformin melatonin resveratrol has not been studies nor approved by the FDA. As a result, conventional oncology knows little about evidence-based non-conventional therapies such as metformin, melatonin or resveratrol.
If you are a MM patient and are considering local radiation for a therapy consider the radioprotective effect of metformin melatonin resveratrol. If you have any questions about multiple myeloma, email me at David.PeopleBeatingCancer@gmail.com
Thank you,
David Emerson
- Cancer Survivor
- Cancer Coach
- Director PeopleBeatingCancer
Radioprotective effect of the anti-diabetic drug metformin
“Metformin is a biguanide currently used in the treatment of diabetes mellitus type 2. Besides its anti-glycemic effects, metformin has been reported to induce different cellular pleiotropic effects, depending on concentration and time of treatment.
Here we report one administration of metformin (0.5 mM) has radioprotective effects in vitro on BJ human fibroblasts, increasing DNA damage repair and increasing SOD1 expression in the nucleus.
Importantly, metformin (200 mg/kg) pre-administration for only 3 days in wild type 129/sv mice, decreases the formation of micronuclei in bone marrow cells and DNA damage in colon and lung tissues compared to control irradiated mice at sub-lethal and lethal doses, increasing the overall survival fraction by 37% after 10Gy total body irradiation.
We next pre-treated with metformin and then exposed 129/sv mice, to a galactic cosmic rays simulation (GCRsim), at the NASA Space Radiation Laboratory (NSRL). We found metformin pre-treatment decreases the presence of bone marrow micronuclei and DNA damage in colon and lung tissues and an increase of 8-oxoguanine DNA glycosylase-1 (OGG1) expression.
Our data highlight a radioprotective effect of metformin through an indirect modulation of the gene expression involved in the cellular detoxification rather than its effects on mitochondria…
Low-dose radiation is an important diagnostic tool (e.g., computed tomography scanning) while high-dose radiation is a well-known approach for the treatment of many tumor types…
Pre-administration of metformin 3 days before irradiation significantly decreases the number of micronuclei in murine bone marrow cells and the number of DNA damage foci in colon and lung tissues, increasing mice survival after exposure to ionizing radiations…
n vivo, pre-administration of 200 mg/kg metformin for three days showed a decrease in the number of micronuclei (MN) in bone marrow cells after 7.5 Gy total body irradiation, compared to the 7.5 Gy irradiated control mice. These results show the ability of metformin to decrease the genotoxic effects induced by IRs, is consistent with what reported by Dan et al. [48] and Cheki et al. [33]…
The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology
“Objective: The objective of this study is to observe the effect of 100-mg melatonin in reducing the levels of double-strand breaks (DSB) induced by 10 mGy and 100 mGy X-ray in peripheral lymphocyte applying H2AX immunofluorescence microscopy and comparing the different efficacies of melatonin ingestion 1 and 2 h before irradiation…
Results: Melatonin ingestion 1 and 2 h before irradiation caused a significant reduction in γH2AX foci. Results further indicate that the change in ingestion of melatonin from 1 to 2 h before exposure had no significant effect. In addition, melatonin administration showed no side effects.
Conclusion: The present study showed that melatonin will prove effective in radioprotection against ionizing radiation (IR)-induced DNA damage in human lymphocytes. Our results suggest ingestion of 100-mg melatonin by patients before exposure to IR in radiology.”
Protection Against Ionizing Radiation-Induced Normal Tissue Damage by Resveratrol: A Systematic Review
“The use of some agents as radioprotectors has been evaluated for protection against normal tissue toxicity following exposure to ionizing radiation. Resveratrol, a natural flavonoid, with antioxidant and anti-inflammatory properties has attracted research interests for its radioprotective potential.
This study systematically evaluates existing studies to examine the radioprotective effectiveness of resveratrol. A literature search of the electronic databases, including
- PubMed,
- Scopus, and
- Embase
was conducted to retrieve articles investigating the protective effect of resveratrol against ionizing radiation-induced damage to normal tissues.
The search timeframe ranged from the inception of each database to January 2020. From an initial search of 231 articles, and after the removal of duplicates as well as applying the predetermined inclusion and exclusion criteria, 33 articles were finally included for this systematic review.
Results showed promising protective effect of resveratrol against ionizing radiation-induced damage to normal tissues. Furthermore, no adverse effect was observed after administering resveratrol. Resveratrol showed the potential to protect against ionizing radiation-induced damage to normal tissue cells via notable mechanisms, including anti-apoptotic and anti-inflammatory effects.
However, further studies on the efficacy of clinical translation of resveratrol would open up more insights, while other gray areas such as the optimal radioprotective dosage of resveratrol requires further investigation. Overall, resveratrol is a potential double-edged sword in cancer therapy while protecting healthy tissues.”