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Renal Cell- Relapse on Lungs-
“We observed that cell proliferation and viability were markedly inhibited by curcumin, while cell apoptosis was promoted…”
Dear Cancer Coach-I had a kidney removed in February of this year due to papillary cell renal cell carcinoma. I was just told that my kidney cancer had metastasized (spread) to my lungs.
The nodules are too small to biopsy right now but it appears to be slow growing. My oncologist thinks treatment won’t begin for 12-18 months. I am pretty much in shock as my oncologist indicated a maximum 10 year prognosis once he starts treatment.
I’m 63 yearrs old now and I feel like time is closing in on me. I have no idea how to deal with this diagnosis. Can you give me some suggestions? John
Dear John- I am sorry to learn of your RCC diagnosis. I understand the shock of a cancer diagnosis or of a metastatic cancer diagnosis, however, you have a number of factors in your favor. Read the info below with the understanding that in my own conventional cancer therapy of chemotherapy/radiation/surgery did little for me other than give me several short, long-term and late-stage side effects.
It was the pursuit of non-toxic therapies coupled with lifestyle therapies that put me into complete remission where I remain today. Being told that a cancer is incurable (as my cancer is, multiple myeloma) is depressing to be sure. But keep in mind that this statement only means that the oncologist sitting across from you doesn’t know how to treat your cancer for the long term.
Take a deep breath and begin learning about those therapies that are available to you.
First and foremost “small, slow-growing” nodules is a positive. While conventional therapies might help you manage your cancer, you can use the 12-18 months to learn about and pursue non-toxic therapies. As the studies linked below indicate, there are numerous antioxidant supplements that show evidence-based kidney killing ability. Further, all of the antioxidants discussed below are low-cost and can be purchased through Amazon. I buy all my supplements online…
I take all below though at a lower maintenance dose as I have been taking them for years now.
“The greatest risk factors for RCC are lifestyle-related; smoking, obesity, and hypertension (high blood pressure) have been estimated to account for up to 50% of cases…
Another suspected risk factor is the long-term use of non-steroidal anti-inflammatory drugs (NSAIDS).[17]”
Please consider quitting smoking if you do. Consider frequent, moderate exercise which over time may help you lose weight and lower your blood pressure. I don’t know what your job is but if you coming in contact with the chemicals listed above figure out how to avoid them.
My general point is that exercise, lifestyle, environment, etc. may slow or even reverse your RCC. I’m big on plan B thinking. If you do need chemo someday, you will be “pre-habilitated.” Meaning, you will be in better physical condition and therefore will handle chemo better.
” In conclusion, our results demonstrate that curcumin exerts anti-cancer effects by negative modulation of the PI3K/AKT signaling pathway and may represent a promising new drug to treat RCC.”
Please let me know if you have any questions about any of the information above.
David Emerson
- Cancer Survivor
- Cancer Coach
- Director PeopleBeatingCancer
Recommended Reading-
- Ken Youner, kidney cancer survivor
- Kidney Cancer Complementary Therapy-Vitamin D
- Stage IV Renal Cell Cancer- IV Alpha Lipoid Acid, Low-Dose Naltrexone
Curcumin Promotes Cell Cycle Arrest and Inhibits Survival of Human Renal Cancer Cells by Negative Modulation of the PI3K/AKT Signaling Pathway.
Curcumin possesses anti-cancer effects. In the current study, we tested the effect of curcumin on cell proliferation, viability, apoptosis, cell cycle phases, and activation of the PI3K/Akt pathway in the renal cell carcinoma (RCC) cell line RCC-949.
We observed that cell proliferation and viability were markedly inhibited by curcumin, while cell apoptosis was promoted.
The latter effect was associated with increased expression of Bcl-2 and diminished expression of Bax (both: mRNA and protein). The cells treated with curcumin increasingly went into cell cycle arrest, which was likely mediated by diminished expression of cyclin B1, as seen in curcumin-treated cells. In addition, curcumin decreased activation of the PI3K/AKT signaling pathway. In conclusion, our results demonstrate that curcumin exerts anti-cancer effects by negative modulation of the PI3K/AKT signaling pathway and may represent a promising new drug to treat RCC.