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Sleep, Proteins and Myeloma
Sleep, proteins and myeloma can all impact each other according to the study linked and excerpted below. In fact, the study demonstrates the affect of just one night of sleep deprivation can have on the average myeloma patient.
I am singling out MM survivors simply because I am one and have had many restless nights affected by chemo, side effects, pain, etc. In addition, many MM patients keep a close eye on their diagnostic testing results. The study linked below helps MM survivors understand that their proteins, for example, can change based on things beyond their MM.
What are all the blood proteins testing in both the complete blood count and metabolic panel for multiple myeloma?
1. Complete Blood Count (CBC)
The CBC is a broad screening test that evaluates the cells circulating in the blood, including red blood cells, white blood cells, and platelets. It doesn’t directly test for proteins, but rather for the following:
- Hemoglobin (Hgb): The protein in red blood cells that carries oxygen.
- Mean Corpuscular Hemoglobin (MCH): The average amount of hemoglobin per red blood cell.
- Mean Corpuscular Hemoglobin Concentration (MCHC): The average concentration of hemoglobin in a given volume of red blood cells.
- Differential: A breakdown of the types of white blood cells, which can include neutrophils, lymphocytes, monocytes, eosinophils, and basophils.
2. Comprehensive Metabolic Panel (CMP)
The CMP assesses various substances in the blood, including several important proteins and other markers related to multiple myeloma. Key components include:
- Total Protein: Measures the total amount of protein in the blood, including albumin and globulin.
- Albumin: A protein made by the liver, albumin levels can be low in multiple myeloma.
- Globulin: This group of proteins includes antibodies. The ratio of albumin to globulin (A/G ratio) is often calculated.
Additional Tests for Multiple Myeloma:
Beyond CBC and CMP, several specific blood protein tests are often used in the diagnosis and monitoring of multiple myeloma:
- Serum Protein Electrophoresis (SPEP): Detects abnormal proteins (M proteins or monoclonal proteins) produced by myeloma cells.
- Immunofixation Electrophoresis (IFE): Identifies the specific type of abnormal protein (e.g., IgG, IgA, etc.).
The study below talks about “six hours of sleep deprivation the next night.” While I don’t remember ever not sleeping for six hours any one night, I have read accounts from numerous MM patients who can’t sleep for multiple days because of their dexamethasone regimen.
I think that if a dex. dose keeps you up for the entire night, your proteins can definitely be off.
The bottom line, in my thinking, is that MM patients must understand that their diagnostic markers will fluctuate. Any single reading can be up or down.
The issue is to observe a trend. In my experience of diagnostic testing, a trend is three or more data points aka three or more results from the test.
As an aside, I put a dropper of Charlotte’s Web CBD oil (no THC) under my tongue before bed each night to help me sleep. I still wake once or twice each night but this CBD oil helps me fall back asleep faster that I would otherwise.
Email me at David.PeopleBeatingCancer@gmail.com if you would like to learn more about MM- both conventional and non-conventional issues.
Thanks,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Just One Night of Poor Sleep May Drive Serum Protein Changes
“A single night of sleep deprivation had a significant impact on human blood serum, based on new data from an analysis of nearly 500 proteins. Compromised sleep has demonstrated negative effects on cardiovascular, immune, and neuronal systems, and previous studies have shown human serum proteome changes after a simulation of night shift work...
In a pilot study published in Sleep Advances, the researchers recruited eight healthy adult women aged 22-57 years with no history of neurologic or psychiatric problems to participate in a study of the effect of compromised sleep on protein profiles, with implications for effects on cells, tissues, and organ systems. Each of the participants served as their own controls, and blood samples were taken after 6 hours of sleep at night, and again after 6 hours of sleep deprivation the following night…
The researchers identified analyzed 494 proteins using mass spectrometry. Of these, 66 were differentially expressed after 6 hours of sleep deprivation…
Further analysis using gene ontology showed changes in response to sleep deprivation in biologic process, molecular function, and immune system process categories, including specific associations related to wound healing, cholesterol transport, high-density lipoprotein particle receptor binding, and granulocyte chemotaxis…
“Our study was able to reveal another set of human serum proteins that were altered by sleep deprivation and could connect similar biological processes to sleep deprivation that have been identified before with slightly different methods,” the researchers concluded…”