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“Some Multiple Myeloma Patients Don’t Need a Transplant!”

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“Some patients in the study haven’t needed a transplant. There may be a benefit from delaying transplantation, (for multiple myeloma)” he said.”

Autologous Stem Cell Transplantation (ASCT) is aggressive, high-dose chemotherapy. Study after study confirms that ASCT does NOT give multiple myeloma patients a longer overall-survival (OS) on average.

Further, aggressive, high-dose chemotherapy mean lots of toxicity. Toxicity means side effects- short, long-term and late stage.

According to the study linking and excerpted below, there is NO difference in patient length of life aka Overall Survival when comparing transplantation now or later.

 

What the myeloma patient gains with an early ASCT is a longer progression-free survival (PFS). Meaning your remission, on average, is deeper and longer than otherwise.

So the choice of the newly diagnosed multiple myeloma patient is to have an ASCT and hopefully achieve a deep, long remission while experiencing short, long-term and late stage side effects or wait and live with fewer side effects and possibly experience remission and relapse.

I was originally diagnosed with multiple myeloma in early 1994. I had an ASCT in 12/95. My remission lasted for about 10 months. I live with long-term and late stage side effects from my conventional therapies.

I have remained in complete remission since 1999 by living an evidence-based, non-toxic, anti-MM lifestyle through nutrition, supplementation, bone health and more.

Click the button on the right of the page to watch a free webinar about the MM Cancer Coaching Program that I researched and designed base on my 20 plus years living with Multiple Myeloma.

Scroll down the page, post a question or a comment and I will reply to you ASAP.

Thanks

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Transplantation for Myeloma Patients — Can It Wait?

“The results show that after induction with lenalidomide (Revlimid, Celgene), bortezomib (Velcade, Takeda), and dexamethasone (RVD) (multiple brands), survival for patients who received transplants as part of consolidation therapy was similar to that for patients who received transplants following relapse

However, progression-free survival (PFS) and response rates were higher for patients in the early transplant group

“This benefit must be weighed against the increased risk of toxic effects associated with high-dose chemotherapy plus transplantation, especially since we found that later transplantation might be as effective as early transplantation in securing long-term survival,” the investigators concluded…

He indicated that with respect to timing, the study showed that overall survival was similar for patients who received transplants early or late (at time of relapse)

Implications for Clinical Practice

In one way, the results of the study may well reflect clinical practice.

Dr Schiffer told Medscape Medical News that the study data show no clear advantage with early transplant. “Some patients in the study haven’t needed a transplant. There may be a benefit from delaying transplantation,” he said.

 

Leave a Comment:

8 comments
Aga says 4 years ago

I am diagnosed with stage 1 mm since 4/2017 I am in receiving inductive treatment RVD 14 days then 7 off got revlamid velcade and dex 2 week two weeks the. Off . I am having gout like synyoms but apart from that seems to be doing fine My biggest problem is my second opinion wants me to have stem cell. I am torn as I think I need non conventional therapy and good diet and exercise options . How can I get information conclusive to make sure I remain in good health .

Reply
    David Emerson says 4 years ago

    Hi Aga-

    I am sorry to read of your MM diagnosis though keep in mind that there is a long and growing list of both conventional (FDA approved) chemotherapy regimens as well as evidence-based non-conventional, anti-MM regimens.

    Your decision of whether or not to have an autonomous stem cell transplant, when to have an ASCT, is up to you. I will link a study below that explains that the timing of when a MMer undergoes an ASCT has no effect on their OS (overall survival- length of life).

    ASCT- Now? Later? Ever?

    The evidence-based, non-toxic, anti-MM therapies included in the multiple myeloma cancer coaching program are definitely options for you. You can have more or less conventional therapy. It is up to you.

    I encourage you to take your MM care one week at a time. Let’s see how your induction therapy of RVd works to control your MM. You can decide if you need to undergo more conventional MM therapy after.

    Let me know if you have any questions.

    David Emerson

    Reply
Lem says 4 years ago

Have low red blood cells

Reply
John says 4 years ago

Need a guidline from you sir.

Reply
    David Emerson says 4 years ago

    Hi John-

    A guideline for what? Do you have MM? If so are you experiencing any symptoms such as bone pain or anemia?

    David Emerson

    Reply
      Lem says 4 years ago

      Just been told by doctor that I have Myeloma, having pains in shoulders with trouble lifting arms.

      Reply
        David Emerson says 4 years ago

        Hi Lem-

        I am sorry to read of your MM diagnosis. Anemia (low red blood cells) and bone pain are common symptoms. Have you had some sort of bone survey such as a skeletal x-ray or MRI? These tests may give you and your oncologist an idea of the bone involvement you are experiencing.

        Keep in mind that though MM is considered incurable by conventional oncology there is a long and growing list of both conventional (FDA approved) therapies as well as evidence-based NON-conventional therapies such as curcumin. Also I have remained in complete remission from my own MM since early ’99.

        Have you been given of stage (I,II,III) of your MM? Are you considering “induction” therapy such as RVd (Revlimid, Velcade, Dexamethasone)? I will email one of the 13 cancer coaching guides that talks about evidence-based integrative therapies for you to consider.

        Let me know if you have any questions.

        Hang in there,

        David Emerson

        Reply
Philippe says 4 years ago

Cannabis oil un synergy with egcg and curcumine flight myeloma cells. Bortezomib kill à lot of patients, never moore.

Reply
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