Cancer Coach- I’m 43 years old I’ve been diagnosed specifically with squamous cell carcinoma of the mandible- one doctor told me that it’s considered stage 4 because it’s penetrated the jaw bone.
Diagnostics- I’ve had x-rays, a biopsy, and two CT scans. I also have trismus which means I can’t open my mouth wide. They said it’s because of the disease so I need to treat that as well because eating is difficult and brushing my teeth is a problem because I can’t fit the toothbrush in my mouth.
I have no other health conditions. Never smoke or drank alcohol. Except for wine three or four times a year. Eat nutritionally balanced meals and exercise regularly. No history of cancer in the family although mom has periodontal issues.
My prognosis with stage 4 squamous cell carcinoma of the mandible is 50 percent with surgery plus 7 weeks chemo at 5 days per week and radiation. They want to throw the kitchen sink at me.
Using Carnivora and trying to build my immune system while I research alternatives. Thanks so much for your help. It’s been very difficult, ok, impossible so far, trying to find people with cancer that have opted against surgery. Diane
Personally, I believe that quality of life is as, if not more important than length of life but you may have to consider, for instance, local radiation and chemo, along with nutritional supplementation, in order to then pursue non-conventional therapies.
Let me know if you have any questions.
thanks and hang in there.
“a subtype of head and neck cancer, is any cancerous tissue growth located in the oral cavity. It may arise as a primary lesion originating in any of the oral tissues, by metastasis from a distant site of origin,.There are several types of oral cancers, but around 90% are squamous cell carcinomas, originating in the tissues that line the mouth and lips. Oral or mouth cancer most commonly involves the tongue. It may also occur on the floor of the mouth, cheek lining, gingiva (gums), lips, or palate (roof of the mouth). Most oral cancers look very similar under the microscope and are called squamous cell carcinoma.”
“Conclusion- The possibility of mandibular involvement is higher in patients where tumours are located with in 1 cm of the mandible. Involvement of mandible through the canal of inferior alveolar nerve in the present study was relatively high (20%). Therefore it is recommended that before a decision is taken to preserve the mandible it should be thoroughly screened for possible involvement.
“The results of our study suggest a careful preoperative examination of the mandible to rule out bone invasion. We propose that spread through the canal of inferior alveolar nerve or the nerve itself may be the cause of increasing rate of local recurrence seen after mandibular conserving surgery.”
“The results demonstrated in vitro the radioprotective effect of trans-resveratrol on cell culture and it was more pronounced when cell culture was irradiated at 500-800 Gy doses in the presence of resveratrol concentrations between 12.5 and 25 µM. These results provide evidence that trans-resveratrol alters the cellular response to ionizing radiation, expanding the knowledge of resveratrol biological properties in physiological and pathological processes, contributing to the development of future studies about the possibility of including resveratrol and its derivatives in dietary supplements given to cancer patients during radiotherapy.”
“Epidermal growth factor receptor (EGFR) is an effective molecular target of anti-cancer therapies. Curcumin is known to inhibit growth, invasion and metastasis by downregulating EGFR expression in some cancer cells.
In this study, we investigated the efficacy of curcumin on proliferation and invasion in SCC-25 cell line. We also explored the effect of curcumin on the activition of EGFR and its downstream signaling molecules Akt, ERK1/2 and STAT3.
Furthermore, we examined the inhibition effect of curcumin on EGF-induced EGFR phosphorylation and SCC-25 cells invasion. Our results showed that curcumin inhibited SCC-25 cells proliferation and induced G2/M phase arrest in a dose-dependent manner. Curcumin also inhibited SCC-25 cells invasion and downregulated MMP-2, MMP-9, uPA and uPAR expression.
We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. Finally, our data showed that crucumin reduced the EGF-induced phosphorylation of EGFR and suppressed EGF-triggered SCC-25 cells invasion.
Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3…”