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Stage 2 Myeloma- CBD to Enhance VRD?
“Researchers also found that sequential use of an initial dose of chemotherapy first and then cannabinoids significantly improved overall results against the blood cancer (MM) cells.”
Hi David- I am a nurse and RN. My husband was diagnosed in May with Multiple Myeloma. I believe he is stage 2. He has started on Velcade, Revlimid and Dexamethasone (VRD) as conventional therapy.
I came across the info about CBD to enhance Velcade recently. We’re very interested this integrative approach to MM therapy. We have taken CBD oil for arthritic pain and had good results.
Ralph is 65 and otherwise is good health. He wants to really do all he can to get into remission for many years. Please contact me about how we can obtain this oil.
We just are not sure what dose my husband needs- once or twice a day?
I am going to start him on CBD oil again. But not sure mg and frequency. Any help would be appreciated but not holding u to any certainties.
Thank you,
Jan
Hi Jan,
You’ve probably been told that MM is incurable. And if your husband undergoes only conventional FDA approved therapies, he will reach remission, relapse, remission, relapse, and end-stage…
My experience is that thinking outside the conventional MM box is the key for your most positive stage 2 myeloma management.
Based on the research I have read and users I have worked with about CBD and MM and/or Velcade, the key issue is the percent of cannabinoids IN the CBD oil. In other words, any CBD oil sold nationally will have only a percent or two of cannabinoids IN the mixture.
If you lived in a state like Colorado or California, you can go to a dispensary that may carry a CBD oil with a high percentage of cannabinoids- say 10-20%. I will link a post below that lists high percentage CBD varieties. Each state can carry different strains. There is no national branding of CBD oil.
The article about CBD and Bortezomib says nothing about dosing. To quote “These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells.”
While the article mentions “CBD by itself” inhibited MM growth, I have read other studies that encourage a component of THC with cannabinoids to be more effective in killing MM.
That issue may be a function of how your husband feels about the “high” he may feel from THC. The people I know who don’t like to get high simply dose CBD oil (a few drops under their tongue) at night right before bed. They say they sleep like a baby.
As for your question about dosing once or twice a day, again the study does not mention dosing. I would say though, that it is up to your husband- how he feels, how he can or cannot function. In general I would say that if he is taking velcade, then more is better. But that depends…
Stage 2 myeloma means that his myeloma has progressed enough that you are correct to combine conventional (RVD) with non-conventional (CBD).
I hope I have addressed all of your issues. Let me know if you have any other questions.
Hang in there,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Recommended Reading:
- Cancer Coaching Testimonials- PeopleBeatingCancer
- Discover the Health Benefits of C-B-D
- Multiple Myeloma Therapy- C-B-D Becomes F.D.A. Approved AKA Mainstream?
5 High Cannabinoid Percentage C-B-D Oil Strains for Multiple Myeloma
“Studies of cannabinoids, while still somewhat thin, indicate that
- C-B-D oil can synergize with certain multiple myeloma chemotherapy regimens,
- C-B-D can manage pain from multiple myeloma and cannabinoids may even be cytotoxic to MM itself.
- C-B-D oil enhances bone health- “
The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2.
“Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM).
Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor.
TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells.
However, no functional role has been ascribed to CBD and TRPV2 in MM. In this study, we identified the presence of heterogeneous CD138+TRPV2+ and CD138+TRPV2- PC populations in MM patients, whereas only the CD138+ TRPV2- population was present in RPMI8226 and U266 MM cell lines.
Because bortezomib (BORT) is commonly used in MM treatment, we investigated the effects of CBD and BORT in CD138+TRPV2- MM cells and in MM cell lines transfected with TRPV2 (CD138+TRPV2+).
These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells. These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in (stage 2 myeloma).
Cannabinoids used in sequence with chemotherapy are a more effective treatment for cancer, say experts
“Cannabinoids -the active chemicals in cannabis – are effective in killing leukemia cells, particularly when used in combination with chemotherapy treatments, new research confirms…
Researchers also found that sequential use of an initial dose of chemotherapy first and then cannabinoids significantly improved overall results against the blood cancer cells. They found that combining existing chemotherapy treatments with cannabinoids had better results than chemotherapy alone, meaning that a similar level of effect could be achieved through using a lower dose of the chemotherapy.
If this were translated to humans, this lower dose of chemotherapy would mean that the side-effects of chemotherapy could be lessened…
“We have shown for the first time that the order in which cannabinoids and chemotherapy are used is crucial in determining the overall effectiveness of this treatment…
“These extracts are highly concentrated and purified, so smoking marijuana will not have a similar effect. But cannabinoids are a very exciting prospect in oncology, and studies such as ours serve to establish the best ways that they should be used to maximise a therapeutic effect.”