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Stem Cell Transplant (ASCT)- Myeloma- Ugly Side Effects

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Hematopoietic stem cell transplantation (ASCT) is aggressive therapy for multiple myeloma patients and can bring serious short, long-term and late stage collateral damage aka side effects.

I was diagnosed with multiple myeloma (MM) in early 1994 and underwent a hematopoietic stem cell transplant (ASCT) in December of 1995. The years following my ASCT have been filled with long-term and late stage side effects caused by my ASCT. While an autologous stem cell transplant has a place in the treatment of multiple myeloma, painful experience has taught me that this aggressive, toxic therapy can damage the patient’s brain, heart, endocrine system, eyes, just about all his/her organs.

Your oncologist probably won’t explain to you all of the life alterning side effects of ASCT. In short, an ASCT should not be used until it is absolutely necessary.

More importantly, it is an open question if the advancements of modern MM therapy has eliminated the need for stem cell transplantation.

In other words, if newly diagnosed MM patients can achieve minimal residual disease (negative) status, or achieve a solid response to his/her induction therapy, an ASCT might not result in longer overall survival on average.

Why would anyone undergo more aggressive, toxic chemotherapy if he/she wasn

t sure of achieving a longer overall survival (length of life)?

There are two sure events that should cause the newly diagnosed MM survivor and caregiver to think long and hard about having an ASCT following induction therapy. And those two events are

solid response to your induction therapy-solid meaning VGPR, CR, sCr, MRD pos and MRD neg.-

experiencing extensive side effects from your induction therapy- if you have to live through skin pain, anemia, nausea, etc. there is a good chance that you are sensitive to chemo and therefore will be sensitive to aggressive, highly toxic therapies that make up the ASCT chemotherapy.

Have you been diagnosed with multiple myeloma? Has your oncologist recommended an ASCT? What was your stage and symptoms at diagnosis? What are your goals?

Scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Long-term health impacts of hematopoietic stem cell transplantation inform recommendations for follow-up

“However, hematopoietic stem cell transplantation (HSCT) survivors are at risk of developing long-term complications, such as

  • endocrinopathies,
  • musculoskeletal disorders,
  • cardiopulmonary compromise and
  • subsequent malignancies.

These complications have a direct impact on the morbidity and mortality experienced by HSCT survivors. Two-thirds of HSCT survivors develop at least one chronic health condition; while a fifth develop severe or life-threatening conditions.

HSCT patients who have survived for at least 5 years post-transplantation are at a fourfold to ninefold increased risk of late mortality for as long as 30 years from HSCT, producing an estimated 30% lower life expectancy compared with the general population…”

Quality of life and mood predicts post-traumatic stress disorder after hematopoietic stem cell transplantation

“In this study, we demonstrate that a significant proportion of patients undergoing HCT report PTSD and depression symptoms at six months post-HCT, further illustrating the substantial psychological burden endured by this population…”

Endocrine disorders during the first year after autologous stem-cell transplant.

“In this prospective study we investigated early (at 3 months) and late (at 12 months) endocrine dysfunctions in 95 consecutive autologous stem-cell transplant recipients (47 men and 48 women) aged 16 to 55 years. The functions of the hypothalamic-pituitary-gonadal/thyroid/adrenal/somatotroph axis were evaluated…

This study documents frequent endocrine disorders during the first year after autologous stem-cell transplant. Despite a tendency to improve, in more than half of the cases, the complications persisted for more than 1 year. Therefore, to diagnose and correct early and late endocrine dysfunctions, endocrine screening is required during the first year in all patients undergoing autografting.”

Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis.

” Patients who have undergone HDT and AHSCT are at significant risk for developing a second malignancy and should receive indefinite follow-up…”

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